scholarly journals Association between Endothelial Nitric Oxide Synthase Polymorphisms and Risk of Metabolic Syndrome

2013 ◽  
Vol 34 (3) ◽  
pp. 187-197 ◽  
Author(s):  
Chiu-Shong Liu ◽  
Ru-Jiun Huang ◽  
Fung-Chang Sung ◽  
Cheng-Chieh Lin ◽  
Chih-Ching Yeh
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Haplotype Analysis ◽  
Variant Genotype ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Self Administered Questionnaire ◽  
Control Study

BACKGROUND: Previous studies inferring that theNOS3gene was associated with the pathogenesis of metabolic syndrome (MetS) had inconsistent findings. We investigated the role of threeNOS3polymorphisms (T-786C, intron 4b/a, and G894T) in the risk of MetS using a hospital-based case-control study.METHODS: We recruited 339 MetS cases and 783 non-MetS controls at a central Taiwanese hospital. Information on sociodemographic and lifestyle factors was obtained using a self-administered questionnaire. Genotypes ofNOS3polymorphisms were compared between cases and controls. Effects of interactions between gene polymorphisms and smoking and between gene polymorphisms and drinking on the risk of MetS were also determined.RESULTS: The T-786C TC+CC genotype was significantly associated with a decreased risk of MetS (odds ratio (OR), 0.63; 95% confidence interval (CI), 0.43–0.91), compared to the T-786C TT genotype, according to a logistic regression analysis. This beneficial effect was much greater for those who had ever smoked cigarettes (OR, 0.47; 95% CI, 0.26–0.87) or those who had not consumed alcohol (OR, 0.45; 95% CI, 0.26–0.77). In addition, the intron 4b/a variant genotype was marginally associated with a reduced risk of MetS (OR, 0.68; 95% CI, 0.47–1.00), compared to the intron 4b/a bb genotype, particularly for never alcohol consumers (OR, 0.56; 95% CI, 0.33–0.95). In the haplotype analysis, there was a 53% decrease in the MetS risk among C4bG haplotype carriers (OR, 0.47; 95% CI, 0.25–0.90), compared to those with the most common T4bG haplotype.CONCLUSIONS: Our results suggest that theNOS3T-786C and intron 4b/a polymorphisms may contribute to the risk of MetS. Further studies are needed to confirm the findings.

The role of endothelial nitric oxide synthase gene polymorphisms in patients with lung cancer

2020 ◽  
Vol 14 (10) ◽  
pp. 948-955
Author(s):  
Canan Koçer ◽  
Necla Benlier ◽  
Sibel Oğuzkan Balci ◽  
Sacide Pehlivan ◽  
Maruf Şanli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Cancer ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

2008 ◽  
Vol 52 (8) ◽  
pp. 1367-1373 ◽  
Author(s):  
Jacqueline C. Escobar Piccoli ◽  
Maria Gabriela Valle Gottlieb ◽  
Luciano Castro ◽  
Luiz Carlos Bodanese ◽  
Euler Roberto Fernandes Manenti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Type Ii Diabetes ◽  
Case Control Study ◽  
Genotype Frequencies ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Control Study

Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.

scholarly journals The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Blazej Misiak ◽  
Marta Krolik ◽  
Anna Kukowka ◽  
Anna Lewera ◽  
Przemyslaw Leszczynski ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Nitric Oxide Synthase ◽  
Cigarette Smoking ◽  
Endothelial Nitric Oxide Synthase ◽  
International Diabetes Federation ◽  
The Metabolic Syndrome ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Background. Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS).Aims. The aim of this study was to evaluate the role of −786T/C polymorphism in the etiology of MS and assess previously reported interaction with cigarette smoking.Methods. Based on International Diabetes Federation 2005 criteria, we recruited randomly 152 subjects with MS and 75 subjects without MS.Results. Allelic and genotype frequencies did not differ significantly between both groups. Total cholesterol level (CHOLT) and intima-media thickness of carotid arteries were significantly higher in −786CC homozygotes, in comparison with −786TC and −786TT patients. Regarding current smoking status, −786C allele was associated with higher CHOLT than −786T allele.Conclusion. Our study indicates the putative role of −786T/C polymorphism in the development of hypercholesterolemia, in patients with MS, which might be enhanced by cigarette smoking.

scholarly journals AnNOS3Haplotype Is Protective against Hypertension in a Caucasian Population

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Georgios D. Kitsios ◽  
Elias Zintzaras
Keyword(s):  
Endothelial Nitric Oxide Synthase ◽  
Mutant Allele ◽  
Haplotype Analysis ◽  
Control Sample ◽  
Case Control ◽  
Caucasian Population ◽  
Rare Haplotype ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

The endothelial nitric oxide synthase gene (NOS3) has been implicated in the development of hypertension, although the specific role of variants and haplotypes has not been clarified. In this study, the association of three polymorphisms (promoter T786C, intronic 4a/b, and nonsynonymous G894T) was tested in a case-control sample of 230 patients with essential hypertension and 306 healthy controls. Haplotype analysis was also performed. The mutant allele of the 4a/b polymorphism showed a protective effect against hypertension under a dominant model (odds , 95% confidence interval (0.44–0.93)), although this effect was not significant after the adjustment for covariates (). The estimated frequency of the haplotype composed of the , 4, and alleles was significantly higher in controls (5.5%) compared to cases (2%). These results indicate that although individualNOS3polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension.

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