Distinct role of endothelial nitric oxide synthase gene polymorphisms from menopausal status in the patients with sporadic breast cancer in Taiwan

Nitric Oxide ◽  
2018 ◽  
Vol 72 ◽  
pp. 1-6 ◽  
Author(s):  
Chien-Hung Chen ◽  
Szu-Hsien Wu ◽  
Yang-Ming Tseng ◽  
Ming-Feng Hou ◽  
Li-Yu Tsai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nitric Oxide ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Sporadic Breast Cancer ◽  
Menopausal Status ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Distinct Role

The role of endothelial nitric oxide synthase gene polymorphisms in patients with lung cancer

2020 ◽  
Vol 14 (10) ◽  
pp. 948-955
Author(s):  
Canan Koçer ◽  
Necla Benlier ◽  
Sibel Oğuzkan Balci ◽  
Sacide Pehlivan ◽  
Maruf Şanli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Cancer ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Role of Endothelial Nitric Oxide Synthase Gene Polymorphisms in Predicting Aneurysmal Subarachnoid Hemorrhage in South Indian Patients

2008 ◽  
Vol 24 (6) ◽  
pp. 333-339 ◽  
Author(s):  
Linda Koshy ◽  
H. V. Easwer ◽  
N. V. Neetha ◽  
Chandrasekhar Natarajan ◽  
R. N. Bhattacharya ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Risk Factors ◽  
Subarachnoid Hemorrhage ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
South Indian ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been implicated as predisposing genetic factors that can predict aneurysmal subarachnoid hemorrhage (aSAH), but with controversial results from different populations. Using a case-control study design, we tested the hypothesis whether variants ineNOSgene can increase risk of aSAH among South Indian patients, either independently, or by interacting with other risk factors of the disease. We enrolled 122 patients, along with 224 ethnically matched controls. We screened the intron-4 27-bp VNTR, the promoter T-786C and the exon-7 G894T SNPs in theeNOSgene. We found marked interethnic differences in the genotype distribution ofeNOSvariants when comparing the South Indian population with the reported frequencies from Caucasian and Japanese populations. Genotype distributions in control and patient populations were found to be in Hardy-Weinberg equilibrium. In patients, the allele, genotype and estimated haplotype frequencies did not differ significantly from the controls. Multiple logistic regression indicated hypertension and smoking as risk factors for the disease, however the risk alleles did not have any interaction with these risk factors. Although theeNOSpolymorphisms were not found to be a likely risk factor for aSAH, the role of factors such as ethnicity, gender, smoking and hypertension should be evaluated cautiously to understand the genotype to phenotype conversion.

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