the G894T polymorphism of endothelial nitric oxide synthase gene and the endocrine-metabolic changes in metabolic syndrome: a romanian case-control study

2009 ◽  
Vol 5 (4) ◽  
pp. 447-458
Author(s):  
Olga Ianas
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Case Control Study ◽  
Case Control ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
G894t Polymorphism ◽  
Control Study

scholarly journals Endothelial nitric oxide synthase intron 4a/b polymorphism and early atherosclerotic changes in hypopituitary GH-deficient adult patients

2008 ◽  
Vol 158 (5) ◽  
pp. 615-622 ◽  
Author(s):  
Fatma Sen ◽  
Mustafa Demirturk ◽  
Neslihan Abaci ◽  
Ebru Golcuk ◽  
Huseyin Oflaz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Case Control Study ◽  
Case Control ◽  
Significant Difference ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Atherosclerotic Changes ◽  
Control Study

ObjectiveEndothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with plasma NO concentrations and coronary artery disease/hypertension in various populations. GH deficiency in adulthood predisposes to reduced NO concentrations and premature atherosclerosis. Our aim was to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function and early atherosclerotic changes in GH-deficient hypopituitary patients.DesignThirty-three hypopituitary GH-deficient patients on conventional replacement therapy other than GH and 43 age-, sex-, and body mass index (BMI)-matched controls were studied in this cross-sectional case–control study.MethodsEarly atherosclerotic changes were determined by flow-mediated dilation (FMD) of brachial artery and carotid artery intima-media thickness (IMT). eNOS4a/b polymorphism was detected by PCR.ResultsHypopituitary patients had significantly higher total/low-density lipoprotein cholesterol and fat mass and lower IGF-I concentrations compared with controls. IMT was significantly higher in patients (0.777±0.23 vs 0.639±0.17 mm, P<0.01). No significant difference was observed with respect to FMD measurements. eNOS4a/b genotype frequencies were similar between patients and controls. Patients carrying ‘a’ allele (a/a and a/b) had significantly higher IMT compared with controls carrying ‘a’ allele and bb genotype (P<0.05). However, logistic regression analysis revealed that presence of hypopituitarism, age≥45 years, and BMI≥27.9 kg/m2 were significant independent predictors of IMT≥0.65 mm.ConclusionNo compelling data are evident to suggest that eNOS4a/b polymorphism modifies the atherosclerotic process in GH-deficient situations. A large case–control study is needed to confirm our findings.

scholarly journals Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

2008 ◽  
Vol 52 (8) ◽  
pp. 1367-1373 ◽  
Author(s):  
Jacqueline C. Escobar Piccoli ◽  
Maria Gabriela Valle Gottlieb ◽  
Luciano Castro ◽  
Luiz Carlos Bodanese ◽  
Euler Roberto Fernandes Manenti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Metabolic Syndrome ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Type Ii Diabetes ◽  
Case Control Study ◽  
Genotype Frequencies ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Control Study

Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.

Sign in / Sign up

Export Citation Format

Share Document