scholarly journals AnNOS3Haplotype Is Protective against Hypertension in a Caucasian Population

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Georgios D. Kitsios ◽  
Elias Zintzaras
Keyword(s):  
Endothelial Nitric Oxide Synthase ◽  
Mutant Allele ◽  
Haplotype Analysis ◽  
Control Sample ◽  
Case Control ◽  
Caucasian Population ◽  
Rare Haplotype ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

The endothelial nitric oxide synthase gene (NOS3) has been implicated in the development of hypertension, although the specific role of variants and haplotypes has not been clarified. In this study, the association of three polymorphisms (promoter T786C, intronic 4a/b, and nonsynonymous G894T) was tested in a case-control sample of 230 patients with essential hypertension and 306 healthy controls. Haplotype analysis was also performed. The mutant allele of the 4a/b polymorphism showed a protective effect against hypertension under a dominant model (odds , 95% confidence interval (0.44–0.93)), although this effect was not significant after the adjustment for covariates (). The estimated frequency of the haplotype composed of the , 4, and alleles was significantly higher in controls (5.5%) compared to cases (2%). These results indicate that although individualNOS3polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension.

scholarly journals Association between Endothelial Nitric Oxide Synthase Polymorphisms and Risk of Metabolic Syndrome

2013 ◽  
Vol 34 (3) ◽  
pp. 187-197 ◽  
Author(s):  
Chiu-Shong Liu ◽  
Ru-Jiun Huang ◽  
Fung-Chang Sung ◽  
Cheng-Chieh Lin ◽  
Chih-Ching Yeh
Keyword(s):  
Metabolic Syndrome ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Polymorphisms ◽  
Haplotype Analysis ◽  
Variant Genotype ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
Self Administered Questionnaire ◽  
Control Study

BACKGROUND: Previous studies inferring that theNOS3gene was associated with the pathogenesis of metabolic syndrome (MetS) had inconsistent findings. We investigated the role of threeNOS3polymorphisms (T-786C, intron 4b/a, and G894T) in the risk of MetS using a hospital-based case-control study.METHODS: We recruited 339 MetS cases and 783 non-MetS controls at a central Taiwanese hospital. Information on sociodemographic and lifestyle factors was obtained using a self-administered questionnaire. Genotypes ofNOS3polymorphisms were compared between cases and controls. Effects of interactions between gene polymorphisms and smoking and between gene polymorphisms and drinking on the risk of MetS were also determined.RESULTS: The T-786C TC+CC genotype was significantly associated with a decreased risk of MetS (odds ratio (OR), 0.63; 95% confidence interval (CI), 0.43–0.91), compared to the T-786C TT genotype, according to a logistic regression analysis. This beneficial effect was much greater for those who had ever smoked cigarettes (OR, 0.47; 95% CI, 0.26–0.87) or those who had not consumed alcohol (OR, 0.45; 95% CI, 0.26–0.77). In addition, the intron 4b/a variant genotype was marginally associated with a reduced risk of MetS (OR, 0.68; 95% CI, 0.47–1.00), compared to the intron 4b/a bb genotype, particularly for never alcohol consumers (OR, 0.56; 95% CI, 0.33–0.95). In the haplotype analysis, there was a 53% decrease in the MetS risk among C4bG haplotype carriers (OR, 0.47; 95% CI, 0.25–0.90), compared to those with the most common T4bG haplotype.CONCLUSIONS: Our results suggest that theNOS3T-786C and intron 4b/a polymorphisms may contribute to the risk of MetS. Further studies are needed to confirm the findings.

scholarly journals Role of Endothelial Nitric Oxide Synthase in Endothelial Cell Migration

1999 ◽  
Vol 19 (5) ◽  
pp. 1156-1161 ◽  
Author(s):  
Toyoaki Murohara ◽  
Bernhard Witzenbichler ◽  
Ioakim Spyridopoulos ◽  
Takayuki Asahara ◽  
Bo Ding ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Migration ◽  
Endothelial Cell ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Endothelial Cell Migration ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide
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