scholarly journals Fabrication of Biodegradable Polyester Nanocomposites by Electrospinning for Tissue Engineering

2011 ◽  
Vol 2011 ◽  
pp. 1-18 ◽  
Author(s):  
Zhi-Cai Xing ◽  
Seung-Jin Han ◽  
Yong-Suk Shin ◽  
Inn-Kyu Kang
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Biodegradable Polymers ◽  
Functional Properties ◽  
Interfacial Adhesion ◽  
Synthetic Polymers ◽  
Biodegradable Polyester ◽  
Tissue Engineering Scaffolds ◽  
Structural And Functional Properties ◽  
Enhanced Properties

Recently, nanocomposites have emerged as an efficient strategy to upgrade the structural and functional properties of synthetic polymers. Polyesters have attracted wide attention because of their biodegradability and biocompatibility. A logic consequence has been the introduction of natural extracellular matrix (ECM) molecules, organic or inorganic nanostructures to biodegradable polymers to produce nanocomposites with enhanced properties. Consequently, the improvement of the interfacial adhesion between biodegradable polymers and natural ECM molecules or nanostructures has become the key technique in the fabrication of nanocomposites. Electrospinning has been employed extensively in the design and development of tissue engineering scaffolds to generate nanofibrous substrates of synthetic biodegradable polymers and to simulate the cellular microenvironment. In this paper, several types of biodegradable polyester nanocomposites were prepared by electrospinning, with the aim of being used as tissue engineering scaffolds. The combination of biodegradable nanofibrous polymers and natural ECM molecules or nanostructures opens new paradigms for tissue engineering applications.

scholarly journals Porous scaffolds with the structure of an interpenetrating polymer network made by gelatin methacrylated nanoparticle-stabilized high internal phase emulsion polymerization targeted for tissue engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22544-22555
Author(s):  
Atefeh Safaei-Yaraziz ◽  
Shiva Akbari-Birgani ◽  
Nasser Nikfarjam
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cell Growth ◽  
Polymer Network ◽  
Synthetic Polymers ◽  
Tissue Scaffolds ◽  
Interpenetrating Polymer Network ◽  
Porous Scaffolds ◽  
Promising Strategy ◽  
Internal Phase

The interlacing of biopolymers and synthetic polymers is a promising strategy to fabricate hydrogel-based tissue scaffolds to biomimic a natural extracellular matrix for cell growth.

scholarly journals Biomimetic hydrogels with spatial- and temporal-controlled chemical cues for tissue engineering

2020 ◽  
Vol 8 (12) ◽  
pp. 3248-3269 ◽  
Author(s):  
Weilue He ◽  
Max Reaume ◽  
Maureen Hennenfent ◽  
Bruce P. Lee ◽  
Rupak Rajachar
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Chemical Cues ◽  
Tissue Engineering Scaffolds ◽  
Spatiotemporal Characteristics

Biomimetic hydrogels work as tissue engineering scaffolds by recapitulating chemical cues and mimicking spatiotemporal characteristics of the native extracellular matrix.

Biodegradable Microfluidic Scaffolds with Tunable Degradation Properties from Amino Alcohol-based Poly(ester amide) Elastomers

2011 ◽  
Vol 1299 ◽  
Author(s):  
Jane Wang ◽  
Tatiana Kniazeva ◽  
Carly F. Campbell ◽  
Robert Langer ◽  
Jeffrey S. Ustin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Biodegradable Polymers ◽  
Half Life ◽  
Microfluidic Devices ◽  
Gas Permeation ◽  
Microfluidic Channels ◽  
Tissue Engineering Scaffolds ◽  
Rapid Prototyping And Manufacturing ◽  
Degradation Properties

ABSTRACTBiodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. In this work, microfluidic devices have been fabricated from elastomeric scaffolds with tunable degradation properties for applications in tissue engineering and regenerative medicine. Most biodegradable polymers suffer from short half life resulting from rapid and poorly controlled degradation upon implantation, exceedingly high stiffness, and limited compatibility with chemical functionalization. Here we report the first microfluidic devices constructed from a recently developed class of biodegradable elastomeric poly(ester amide)s, poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s (APS), showing a much longer and highly tunable in vivo degradation half-life comparing to many other commonly used biodegradable polymers. The device is molded in a similar approach to that reported previously for conventional biodegradable polymers, and the bonded microfluidic channels are shown to be capable of supporting physiologic levels of flow and pressure. The device has been tested for degradation rate and gas permeation properties in order to predict performance in the implantation environment. This device is high resolution and fully biodegradable; the fabrication process is fast, inexpensive, reproducible, and scalable, making it the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds and vasculature and tissue and organ replacements.

scholarly journals Polymeric Scaffolds in Tissue Engineering Application: A Review

2011 ◽  
Vol 2011 ◽  
pp. 1-19 ◽  
Author(s):  
Brahatheeswaran Dhandayuthapani ◽  
Yasuhiko Yoshida ◽  
Toru Maekawa ◽  
D. Sakthi Kumar
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Engineering Application ◽  
Biologically Active ◽  
Porous Scaffolds ◽  
Tissue Engineering Application ◽  
Tissue Engineering Scaffolds ◽  
Matrix Deposition ◽  
Bioactive Agents ◽  
Regenerate Tissue

Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.

scholarly journals Electrospun Collagen: A Tissue Engineering Scaffold with Unique Functional Properties in a Wide Variety of Applications

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Balendu Shekhar Jha ◽  
Chantal E. Ayres ◽  
James R. Bowman ◽  
Todd A. Telemeco ◽  
Scott A. Sell ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Functional Properties ◽  
Type I Collagen ◽  
Bone Mineralization ◽  
Biological Properties ◽  
Type I ◽  
Peptide Fragments ◽  
Tissue Engineering Scaffolds ◽  
Fundamental Properties ◽  
Electrospun Gelatin

Type I collagen and gelatin, a derivative of Type I collagen that has been denatured, can each be electrospun into tissue engineering scaffolds composed of nano- to micron-scale diameter fibers. We characterize the biological activity of these materials in a variety of tissue engineering applications, including endothelial cell-scaffold interactions, the onset of bone mineralization, dermal reconstruction, and the fabrication of skeletal muscle prosthetics. Electrospun collgen (esC) consistently exhibited unique biological properties in these functional assays. Even though gelatin can be spun into fibrillar scaffolds that resemble scaffolds of esC, our assays reveal that electrospun gelatin (esG) lacks intact α chains and is composed of proinflammatory peptide fragments. In contrast, esC retains intact α chains and is enriched in the α 2(I) subunit. The distinct fundamental properties of the constituent subunits that make up esC and esG appear to define their biological and functional properties.

scholarly journals Structural and Functional Properties of the Extracellular Matrix

2018 ◽  
Vol 7 (3) ◽  
pp. 251-260
Author(s):  
Rasime Sevgi CENAN ◽  
Ekin ERGİN ◽  
Yahya EKİCİ ◽  
Fatma Belgin ATAÇ
Keyword(s):  
Extracellular Matrix ◽  
Functional Properties ◽  
Structural And Functional Properties

scholarly journals Mechanically strong interpenetrating network hydrogels for differential cellular adhesion

RSC Advances ◽  
2017 ◽  
Vol 7 (29) ◽  
pp. 18046-18053 ◽  
Author(s):  
Chong Shen ◽  
Yuyan Li ◽  
Huadi Wang ◽  
Qin Meng
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cellular Adhesion ◽  
Interpenetrating Network ◽  
Tissue Engineering Scaffolds

Hydrogels as “soft-and-wet” materials have been widely used as tissue engineering scaffolds due to their similarity to natural extracellular matrix.

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