scholarly journals Biomimetic hydrogels with spatial- and temporal-controlled chemical cues for tissue engineering

2020 ◽  
Vol 8 (12) ◽  
pp. 3248-3269 ◽  
Author(s):  
Weilue He ◽  
Max Reaume ◽  
Maureen Hennenfent ◽  
Bruce P. Lee ◽  
Rupak Rajachar
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Chemical Cues ◽  
Tissue Engineering Scaffolds ◽  
Spatiotemporal Characteristics

Biomimetic hydrogels work as tissue engineering scaffolds by recapitulating chemical cues and mimicking spatiotemporal characteristics of the native extracellular matrix.

scholarly journals Polymeric Scaffolds in Tissue Engineering Application: A Review

2011 ◽  
Vol 2011 ◽  
pp. 1-19 ◽  
Author(s):  
Brahatheeswaran Dhandayuthapani ◽  
Yasuhiko Yoshida ◽  
Toru Maekawa ◽  
D. Sakthi Kumar
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Engineering Application ◽  
Biologically Active ◽  
Porous Scaffolds ◽  
Tissue Engineering Application ◽  
Tissue Engineering Scaffolds ◽  
Matrix Deposition ◽  
Bioactive Agents ◽  
Regenerate Tissue

Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.

scholarly journals Mechanically strong interpenetrating network hydrogels for differential cellular adhesion

RSC Advances ◽  
2017 ◽  
Vol 7 (29) ◽  
pp. 18046-18053 ◽  
Author(s):  
Chong Shen ◽  
Yuyan Li ◽  
Huadi Wang ◽  
Qin Meng
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cellular Adhesion ◽  
Interpenetrating Network ◽  
Tissue Engineering Scaffolds

Hydrogels as “soft-and-wet” materials have been widely used as tissue engineering scaffolds due to their similarity to natural extracellular matrix.

scholarly journals Biochemical and biophysical aspects of collagen nanostructure in the extracellular matrix

2007 ◽  
pp. S51-S60
Author(s):  
L Koláčná ◽  
J Bakešová ◽  
F Varga ◽  
E Košťáková ◽  
D Lukáš ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Structural Integrity ◽  
Dominant Role ◽  
Three Dimensional ◽  
Biomechanical Properties ◽  
Biophysical Properties ◽  
Tissue Engineering Scaffolds ◽  
Artificial Tissue ◽  
Cell Growth And Proliferation

ECM is composed of different collagenous and non-collagenous proteins. Collagen nanofibers play a dominant role in maintaining the biological and structural integrity of various tissues and organs, including bone, skin, tendon, blood vessels, and cartilage. Artificial collagen nanofibers are increasingly significant in numerous tissue engineering applications and seem to be ideal scaffolds for cell growth and proliferation. The modern tissue engineering task is to develop three-dimensional scaffolds of appropriate biological and biomechanical properties, at the same time mimicking the natural extracellular matrix and promoting tissue regeneration. Furthermore, it should be biodegradable, bioresorbable and non-inflammatory, should provide sufficient nutrient supply and have appropriate viscoelasticity and strength. Attributed to collagen features mentioned above, collagen fibers represent an obvious appropriate material for tissue engineering scaffolds. The aim of this minireview is, besides encapsulation of the basic biochemical and biophysical properties of collagen, to summarize the most promising modern methods and technologies for production of collagen nanofibers and scaffolds for artificial tissue development.

scholarly journals Fabrication of Biodegradable Polyester Nanocomposites by Electrospinning for Tissue Engineering

2011 ◽  
Vol 2011 ◽  
pp. 1-18 ◽  
Author(s):  
Zhi-Cai Xing ◽  
Seung-Jin Han ◽  
Yong-Suk Shin ◽  
Inn-Kyu Kang
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Biodegradable Polymers ◽  
Functional Properties ◽  
Interfacial Adhesion ◽  
Synthetic Polymers ◽  
Biodegradable Polyester ◽  
Tissue Engineering Scaffolds ◽  
Structural And Functional Properties ◽  
Enhanced Properties

Recently, nanocomposites have emerged as an efficient strategy to upgrade the structural and functional properties of synthetic polymers. Polyesters have attracted wide attention because of their biodegradability and biocompatibility. A logic consequence has been the introduction of natural extracellular matrix (ECM) molecules, organic or inorganic nanostructures to biodegradable polymers to produce nanocomposites with enhanced properties. Consequently, the improvement of the interfacial adhesion between biodegradable polymers and natural ECM molecules or nanostructures has become the key technique in the fabrication of nanocomposites. Electrospinning has been employed extensively in the design and development of tissue engineering scaffolds to generate nanofibrous substrates of synthetic biodegradable polymers and to simulate the cellular microenvironment. In this paper, several types of biodegradable polyester nanocomposites were prepared by electrospinning, with the aim of being used as tissue engineering scaffolds. The combination of biodegradable nanofibrous polymers and natural ECM molecules or nanostructures opens new paradigms for tissue engineering applications.

Novel tissue engineering scaffolds as wound dressings loaded with Alkannins/Shikonins as active ingredients

2019 ◽  
Author(s):  
AS Arampatzis ◽  
K Theodoridis ◽  
E Aggelidou ◽  
KN Kontogiannopoulos ◽  
I Tsivintzelis ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Dressings ◽  
Active Ingredients ◽  
Tissue Engineering Scaffolds

HYDROXYAPATITE, ALGINATE, AND CHITOSAN FOR BONE SCAFFOLDS: SPECTROSCOPY STUDY

2016 ◽  
Vol 19 (2) ◽  
pp. 93-100
Author(s):  
Lalita El Milla
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Functional Groups ◽  
Bone Growth ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Powder ◽  
Materials Used

Scaffolds is three dimensional structure that serves as a framework for bone growth. Natural materials are often used in synthesis of bone tissue engineering scaffolds with respect to compliance with the content of the human body. Among the materials used to make scafffold was hydroxyapatite, alginate and chitosan. Hydroxyapatite powder obtained by mixing phosphoric acid and calcium hydroxide, alginate powders extracted from brown algae and chitosan powder acetylated from crab. The purpose of this study was to examine the functional groups of hydroxyapatite, alginate and chitosan. The method used in this study was laboratory experimental using Fourier Transform Infrared (FTIR) spectroscopy for hydroxyapatite, alginate and chitosan powders. The results indicated the presence of functional groups PO43-, O-H and CO32- in hydroxyapatite. In alginate there were O-H, C=O, COOH and C-O-C functional groups, whereas in chitosan there were O-H, N-H, C=O, C-N, and C-O-C. It was concluded that the third material containing functional groups as found in humans that correspond to the scaffolds material in bone tissue engineering.

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