scholarly journals Microwave Induced Improved Synthesis of Some Novel Substituted 1, 3-Diarylpropenones and their Antimicrobial Activity

2011 ◽  
Vol 8 (2) ◽  
pp. 665-670 ◽  
Author(s):  
K. L. Ameta ◽  
Biresh Kumar ◽  
Nitu S. Rathore
Keyword(s):  
Simple Procedure ◽  
Aromatic Aldehydes ◽  
Solid Support ◽  
Fast Reaction ◽  
H Nmr ◽  
Reaction Condition ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Substituted 1 ◽  
C Nmr

Application of solid support, solvent free reaction condition and a dynamic microwave power system in the chemical synthesis of some novel 1, 3-diaryl-propenones has been described. A series of chalcones(3a-h)were synthesized by the condensation of 4-hydroxy-3,5-dinitroacetophenone with various substituted aromatic aldehydes in presence of montmorrilonite K10 as a catalyst and solid support media under microwave irradiation. The protocol offers several advantages such as simple procedure, fast reaction rate, mild reaction condition, eco-friendly and improved yield as compared to conventional methods. These compounds have been screened for their antibacterial and antifungal activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of elemental analysis,1H NMR,13C NMR and IR spectral data.

scholarly journals Synthesis and Antimicrobial Screening of Novel 4-Substituted Phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Namratha Bhandari ◽  
Santosh L. Gaonkar
Keyword(s):  
Convenient Method ◽  
Nmr Spectra ◽  
Spectral Studies ◽  
Antimicrobial Screening ◽  
Antifungal Activities ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal ◽  
C Nmr

The paper describes a convenient method for the preparation of 4-substituted phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]-2H-1,2,4-triazole-3-thiones. The structures of the synthesized compounds are established by the results of LCMS, 1H NMR, 13C NMR, and IR and elemental analyses. The mercaptotriazoles are indicated to be in thione form by 1H NMR spectra. All the synthesized compounds have been screened for antibacterial and antifungal activities. Compounds 12d and 12h exhibit encouraging results, while the remaining compounds show moderate activities. On the basis of spectral studies, formation of 2-amino-1,3,4-thiadiazoles from the isobenzofuran acyl thiosemicarbazides 11(a–h) is ruled out.

scholarly journals Synthesis and Antimicrobial Activity of Some Chalcone Derivatives

2008 ◽  
Vol 5 (3) ◽  
pp. 461-466 ◽  
Author(s):  
Y. Rajendra Prasad ◽  
A. Lakshmana Rao ◽  
R. Rambabu
Keyword(s):  
Aqueous Solution ◽  
Antimicrobial Activity ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Antimicrobial Agents ◽  
Aromatic Aldehydes ◽  
Plate Method ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by means of their IR,1H-NMR spectral data and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.

scholarly journals Synthesis andIn VitroBiological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Amaç Fatih Tuyun ◽  
Nilüfer Bayrak ◽  
Hatice Yıldırım ◽  
Nihal Onul ◽  
Emel Mataraci Kara ◽  
...  
Keyword(s):  
Spectral Properties ◽  
Antifungal Compounds ◽  
New Members ◽  
Gram Positive Bacteria ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Aryl Amines ◽  
Antibacterial And Antifungal ◽  
C Nmr

A series of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a–h) by the reaction of 2,3-dichloro-1,4-naphthoquinone with aryl amines (2a–h) and benzo[b]phenazine-6,11-dione derivatives (4a–c) by the treatment of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a–h) with sodium azide were synthesized and tested for theirin vitroantibacterial and antifungal activities. The results suggest that compounds3dand3ghad potent antifungal activity againstCandida albicans(MIC = 78.12 μg/mL). All synthesized compounds (3a–h,4a–c) possessed activity againstE. faecaliswith MIC values of between 312.5 and 1250 μg/mL. Benzo[b]phenazine-6,11-dione derivatives (4a–c) were mostly active against Gram-positive bacteria. The structures of the new members of the series were established on the basis of their spectral properties (IR,1H NMR,13C NMR, and mass spectrometry).

scholarly journals Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Mohamad Yusuf ◽  
Indu Solanki ◽  
Payal Jain
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activities ◽  
Significant Activity ◽  
Rigorous Analysis ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
C Nmr

The diisochromenochromen-4-one3a-3b,4a-4c,5a-6a  & 7have been prepared from the photocyclization reaction of bischromen-4-one2a-2e. The later compounds are obtained from the O-alkylation of the suitable 3-hydroxy-2-aryl-4H-chromen-4-one1a-1ewith 4,4′-bischloromethyl-diphenyl in dry acetone, anhydrous K2CO3, and PTC (Bu4N+I−) under refluxing conditions. The structures of compounds2a-2e,3a-3b,4a-4c,5a-6a  & 7have been characterized from the rigorous analysis of their IR,1H-NMR,13C-NMR, ESI-Mass, and elemental analysis. The antibacterial and antifungal activities of the synthesized products were also evaluated against theKlebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, andAspergillus janusandPenicillium glabrum, respectively. Some of the tested compounds showed significant activity against the above-said microorganisms.

scholarly journals Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Chandrashekhar P. Pandhurnekar ◽  
Ekta M. Meshram ◽  
Himani N. Chopde ◽  
Rameshkumar J. Batra
Keyword(s):  
Spectroscopic Techniques ◽  
Pyrimidine Derivatives ◽  
Mass Spectral ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Biological Potency ◽  
Antibacterial And Antifungal ◽  
Anti Fungal ◽  
C Nmr

With the aim of synthesizing new heterocyclic compounds and exploring biological potency, new series of chalcones, that is, 3-(2-hydroxy-5-(aryl-diazenyl)phenyl)-1-(aryl)prop-2-en-1-one and their pyrimidine derivatives, that is, 4-(2-hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols were synthesized using different aromatic amines and salicylaldehyde as starting moieties. The structures of newly synthesized compounds were confirmed using different spectroscopic techniques such as IR, 1H-NMR, 13C-NMR, and mass spectral analysis, and elemental analysis. The newly synthesized pyrimidines derivatives were screened for their in vitro antibacterial and antifungal activities. It was observed that some of the newly synthesized compounds had shown promising activity against several bacterial and fungal stains. Anti-bacterial activity and anti-fungal activity studies revealed that pyrimidine derivatives consisting of nitro group in their molecular structure possess better activity than their corresponding chalcones.

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Nalidixic Acid ◽  
Copper Complexes ◽  
Biological Activities ◽  
Bidentate Coordination ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Substituted 1

A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxadiazole ring. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes possess antibacterial and antifungal activities better than the oxadiazoles while they have better antioxidant activity then copper complexes. Parent hydrazones were better in all biological activities than synthesized oxadiazoles.

Ultrasound-assisted aqua-mediated synthesis of multi-substituted tetrahydropyridine-3-carboxylates using N-carboxymethyl-3-pyridinium hydrogensulfate ([N-CH2CO2H-3-pic]+HSO4−) as a new efficient ionic liquid catalyst

2021 ◽  
Vol 3 (6) ◽  
Author(s):  
Kobra Nikoofar ◽  
Fatemeh Shahriyari
Keyword(s):  
Ionic Liquid ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
H Nmr ◽  
Sonic Waves ◽  
Ft Ir ◽  
High Yields ◽  
Work Up ◽  
C Nmr

AbstractA simple, straightforward, and ultrasound-promoted method for the preparation of some highly functionalized tetrahydropyridines reported via pseudo five-component reaction of (hetero)aromatic aldehydes, different anilines, and alkyl acetoacetates in the presence of [N-CH2CO2H-3-pic]+HSO4−, as a novel ionic liquid, in green aqueous medium. The IL was synthesized utilizing simple and easily-handled substrates and characterized by FT-IR, 1H NMR, 13C NMR, GC-MASS, FESEM, EDX, and TGA/DTG techniques. The procedure contains some highlighted aspects which are: (a) performing the MCR in the presence of aqua and sonic waves, as two main important and environmentally benign indexes in green and economic chemistry, (b) high yields of products within short reaction times, (c) convenient work-up procedure, (d) preparing the new IL via simple substrates and procedure.

Microwave synthesis of new biologically important 1,4-dihydropyridines containing benzothiazole moiety

2010 ◽  
Vol 75 (3) ◽  
pp. 275-287 ◽  
Author(s):  
Mithlesh ◽  
Pawan K. Pareek ◽  
Hemraj Chippa ◽  
Ravikant ◽  
Krishan G. Ojha
Keyword(s):  
Microwave Irradiation ◽  
Aromatic Aldehyde ◽  
Microwave Synthesis ◽  
Solid Support ◽  
Solvent Free ◽  
Microwave Irradiation Method ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Active Methylene

2,3,5,6-Tetrasubstituted-4-aryl-1-(6-ethoxybenzothiazol-2-yl)-1,4-dihydropyridines were synthesized by the reaction of 2-amino-6-ethoxybenzothiazole, an aromatic aldehyde and an active methylene compound in methanol by conventional or microwave irradiation method (solvent-free or with solid support). All compounds were tested for antibacterial and antifungal activities and the results were compared with standard drugs. Their acaricidal and antifeedant activities were also tested.

scholarly journals From Synthesis to Biological Impact of Pd (II) Complexes: Synthesis, Characterization, and Antimicrobial and Scavenging Activity

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Nitin Kumar Sharma ◽  
Rakesh Kumar Ameta ◽  
Man Singh
Keyword(s):  
Physiological Condition ◽  
Antioxidant Activities ◽  
Spectroscopic Technique ◽  
Scavenging Activity ◽  
Biological Impact ◽  
Antibacterial And Antifungal Activities ◽  
Biological Potential ◽  
Antibacterial And Antifungal ◽  
C Nmr

The Pd (II) complexes with a series of halosubstituted benzylamine ligands (BLs) have been synthesized and characterized with different spectroscopic technique such as FTIR, UV/Vis, LCMS,1H, and13C NMR. Their molecular sustainability in different solvents such as DMSO, DMSO : H2O, and DMSO : PBS at physiological condition (pH 7.2) was determined by UV/Vis spectrophotometer. Thein vitroantibacterial and antifungal activities of the complexes were investigated against Gram-positive and Gram-negative microbes and two different fungi indicated their significant biological potential. Additionally, their antioxidant activity has been analyzed with DPPH•free radical through spectrophotometric method and the result inferred them as an antioxidant. The stronger antibacterial and antioxidant activities of the synthesized complexes suggested them as a stronger antimicrobial agent. Our study advances the biological importance of palladium (II) amine complexes in the field of antimicrobial and antioxidant activities.

Infrared, 1H-NMR Spectral Studies of some Methyl 6-O-Myristoyl-α-D-Glucopyranoside Derivatives: Assessment of Antimicrobial Effects

2015 ◽  
Vol 58 ◽  
pp. 122-136 ◽  
Author(s):  
Sarkar M.A. Kawsar ◽  
Khaleda Mymona ◽  
Refat Asma ◽  
Mohammad A. Manchur ◽  
Yasuhiro Koide ◽  
...  
Keyword(s):  
Pathogenic Fungi ◽  
Spectral Studies ◽  
Bacterial Strains ◽  
Substitution Product ◽  
Antifungal Activities ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Fungal Phytopathogens ◽  
Antibacterial And Antifungal

This study was carried out to regioselective myristoylation of methyl α-D-glucopyranoside (1) using the direct acylation method gave the corresponding methyl 6-O-myristoyl-α-D-glucopyranoside (2) in fair yield. A number of 2,3,4-tri-O-acyl derivatives (3-15) of this 6-O-substitution product using a wide variety of acylating agents were also prepared in order to obtain newer derivatives of synthetic and biological importance. The reaction conditions are reasonably simple and yields were very good. The structures of the title compounds (2-15) were established by using analytical, physicochemical techniques and spectroscopic data (IR and 1H-NMR). All the synthesized compounds were employed as test chemicals for in vitro antimicrobial functionality test against Gram-positive Bacillus subtilis, Staphylococcus aureus, Gram-negative Escherichia coli, Pseudomonas aeruginosa bacteria and plant pathogenic fungi Aspergillus niger and Candida albicans. For comparative studies, antimicrobial activity of standard antibiotics, Ampicillin and Nystatin were also carried out against these microorganisms. The study revealed that the tested samples exhibited moderate to good antibacterial and antifungal activities. It was also observed that the test substances were more effective against fungal phytopathogens than those of the human bacterial strains. Encouragingly, a number of tested chemicals showed nearest antibacterial and antifungal activities with the standard antibiotics employed.

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