scholarly journals Synthesis and Antimicrobial Activity of Some Chalcone Derivatives

2008 ◽  
Vol 5 (3) ◽  
pp. 461-466 ◽  
Author(s):  
Y. Rajendra Prasad ◽  
A. Lakshmana Rao ◽  
R. Rambabu
Keyword(s):  
Aqueous Solution ◽  
Antimicrobial Activity ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Antimicrobial Agents ◽  
Aromatic Aldehydes ◽  
Plate Method ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by means of their IR,1H-NMR spectral data and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.

scholarly journals Synthesis and Antimicrobial Activity of SomeNovel Benzimidazolyl Chalcones

2009 ◽  
Vol 6 (1) ◽  
pp. 196-200 ◽  
Author(s):  
B. A. Baviskar ◽  
Bhagyesh Baviskar ◽  
M. R. Shiradkar ◽  
U. A. Deokate ◽  
S. S. Khadabadi
Keyword(s):  
Antimicrobial Activity ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Potassium Hydroxide Solution ◽  
Aromatic Aldehydes ◽  
Plate Method ◽  
H Nmr ◽  
Aqueous Potassium Hydroxide

Some novel benzimidazolyl chalcones were synthesized by condensation ofN-(4-(1H-benzo[d]imidazol-2-yl)phenyl)acetamide with aromatic aldehydes in presence of aqueous potassium hydroxide solution at room temperature. All the synthesized compounds were characterized on the basis of their IR,1H NMR spectroscopic data and elemental analysis. All the compounds have been screened for antimicrobial activity by the cup-plate method.

scholarly journals Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl Coumarin

2006 ◽  
Vol 3 (4) ◽  
pp. 236-241 ◽  
Author(s):  
Y. Rajendra Prasad ◽  
P. Ravi Kumar ◽  
Ch. Asha Deepti ◽  
M. Venkata Ramana
Keyword(s):  
Antimicrobial Activity ◽  
Spectroscopic Data ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Potassium Hydroxide Solution ◽  
Plate Method ◽  
Hydroxide Solution ◽  
H Nmr

Five novel chalcones were synthesised by condensing 2-hydroxy-1-acetonaphthone with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation and another five novel chalcones were prepared by refluxing 3-acetyl coumarin with aldehydes in the presence of piperidine in ethanol. All these compounds were characterised by means of their IR,1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds were evaluated by the cup plate method.

scholarly journals Synthesis of Diverse Fused Tetracyclic Thiazepine-Chalcone Derivatives by Claisen-Schmidt Condensation Reaction and their Antimicrobial Activity

2020 ◽  
Vol 32 (11) ◽  
pp. 2860-2864
Author(s):  
Jayanti B. Hirani ◽  
Mayank K. Pandya ◽  
Suresh B. Koradiya
Keyword(s):  
Room Temperature ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Base Catalyst ◽  
Bacterial Strains ◽  
Plate Method ◽  
Strong Base ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

To develop antimicrobial agent, a series of thiazepine-chalcones was synthesized by Claisen-Schmidt condensation between the couplings of aryl ketone in three steps protocol and different aromatic aldehydes under strong base catalyst at room temperature. The characterization of final products were carried out by IR, 1H & 13C NMR and elemental analysis. The synthesized compounds were also evaluated for their antibacterial and antifungal activities using specific Gram positive and Gram-negative bacterial strains using cup plate method.

scholarly journals Synthesis and Antimicrobial Activity of Some New Chalcones of 2-Acetyl Pyridine

2008 ◽  
Vol 5 (1) ◽  
pp. 144-148 ◽  
Author(s):  
Y. Rajendra Prasad ◽  
P. Praveen Kumar ◽  
P. Ravi Kumar ◽  
A. Srinivasa Rao
Keyword(s):  
Antimicrobial Activity ◽  
Spectroscopic Data ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Potassium Hydroxide Solution ◽  
Plate Method ◽  
Hydroxide Solution ◽  
H Nmr

Six new chalcones were synthesised by condensing 2-acetyl pyridine with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. All these compounds were characterised by means of their IR,1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.

scholarly journals Synthesis and Biological Evaluation of Some New Chalcones Containing 2,5-Dimethylfuran Moiety

2011 ◽  
Vol 8 (2) ◽  
pp. 541-546 ◽  
Author(s):  
S. Sridhar ◽  
S. C. Dinda ◽  
Y. Rajendra Prasad
Keyword(s):  
Aqueous Solution ◽  
Spectral Data ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Aromatic Aldehydes ◽  
Biological Evaluation ◽  
Significant Activity ◽  
H Nmr ◽  
Elemental Analyses ◽  
Synthesis And Biological Evaluation

A series of new chalcones(3a-g)were prepared by Claisen-Schmidt condensation of 3-acetyl-2,5-dimethylfuran with various substituted aromatic aldehydes in presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized chalcones were characterized by means of their IR,1H NMRspectral data and elemental analyses. When these chalcones were evaluated for antimicrobial and anti-inflammatory activities, some of them were found to possess significant activity, when compared to standard drugs.

scholarly journals Synthesis and Antimicrobial Activity of Pyrimidine Salts with Chloranilic and Picric Acids

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
C. Mallikarjunaswamy ◽  
D. G. Bhadregowda ◽  
L. Mallesha
Keyword(s):  
Antimicrobial Activity ◽  
The Other ◽  
Spectral Studies ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Uv Visible ◽  
Antibacterial And Antifungal

Pyrimidine salts such as 2-methyl-5-nitro-phenyl-(4-pyridin-3-yl-pyrimidin-2-yl)-amine (1) and 4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-yl-amino)-phenyl-amine (2) with chloranilic and picric acids were synthesized, and theirin vitroantibacterial and antifungal activities were evaluated. The synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, and1H NMR spectral studies. Compound2aexhibited good inhibition towards antimicrobial activity compared to the other compounds.

scholarly journals Synthesis and Antimicrobial Activity of 1-[2-(10-p-Chlorobenzyl) phenothiazinyl]-3-(substituted aryl)-2-propen-1-ones

2009 ◽  
Vol 6 (s1) ◽  
pp. S254-S258 ◽  
Author(s):  
R. K. Upadhyay ◽  
Megha S. Upadhyay ◽  
S. Jain
Keyword(s):  
Antimicrobial Activity ◽  
Spectroscopic Data ◽  
Room Temperature ◽  
Antimicrobial Agents ◽  
Sodium Hydroxide Solution ◽  
New Products ◽  
Subsequent Reaction ◽  
Filter Paper Disc ◽  
H Nmr ◽  
Paper Disc

Aiming at the development of antimicrobial agents, we have synthesized nine chlorobenzyl substituted phenothiazinyl chalcones by condensing 2-acetyl phenothiazine with aldehyde derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Claisen - Schmidt condensation and subsequent reaction of products withp-chlorobenzyl bromide. Structures of these compounds were elucidated by their IR, 'H NMR spectroscopic data and microonalyses. The antimicrobial activity of the new products was evaluated by Filter Paper Disc Method.

scholarly journals Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho[2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives

2012 ◽  
Vol 9 (1) ◽  
pp. 175-180 ◽  
Author(s):  
Sanjeevan S. Gaikwad ◽  
Venkat S. Suryawanshi ◽  
Kishan S. Lohar ◽  
Dhanaji V. Jadhav ◽  
Narayan D. Shinde
Keyword(s):  
Biological Activity ◽  
Potassium Hydroxide ◽  
Alcoholic Solution ◽  
Significant Activity ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Reflux Temperature

A series of new oxopyrimidine were prepared by cyclocondensation route with various substituted chalcones in presence of alcoholic solution of potassium hydroxide at reflux temperature. The synthesized oxopyrimidine derivatives were characterized by means of their IR,1H NMR, mass spectral data and elemental analysis. The synthesized oxopyrimidines derivatives were evaluated for antibacterial and antifungal activities, some of them were found to possess significant activity.

scholarly journals Synthesis and Biological Evaluation of 2-(3-Methyl-2-oxoquinoxalin-1(2H)-yl)-N'-(substituted phenyl-methyledene/ethylidene)acetohydrazides

2010 ◽  
Vol 7 (4) ◽  
pp. 1435-1439 ◽  
Author(s):  
Gopal Krishna Rao ◽  
R. B. Kotnal ◽  
P. N. Sanjay Pai
Keyword(s):  
Antimicrobial Activity ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Aromatic Aldehydes ◽  
Biological Evaluation ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Quinoxaline Derivatives ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation

A series of quinoxaline derivatives was prepared and evaluated for antitubercular, antibacterial and antifungal activities. The title compounds were prepared by condensation of substituted aromatic aldehydes and substituted acetophenones with 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl) acetohydrazide. Structures of all these compounds were confirmed by their spectral studies. Among synthesized compounds (4r, 4t, 4u, 4wand4x) have shown good anti tubercular activity (25 µg mL-1) when compared to reference drugs pyrazinamide (10 µg mL-1) and streptomycin (7.5 µg mL-1). In this study, few derivatives showed broad spectrum of antimicrobial activity at low concentration. The MICs (Minimum inhibitory concentration) of some compounds are 2-4 µg mL-1.

scholarly journals Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives

2011 ◽  
Vol 61 (4) ◽  
pp. 447-455 ◽  
Author(s):  
Soni Singh ◽  
Sujata Bhat
Keyword(s):  
Antimicrobial Activity ◽  
Low Cost ◽  
Aromatic Aldehydes ◽  
Dilution Method ◽  
Phenylpropionic Acid ◽  
Antimicrobial Potential ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Vinyl Derivatives

Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity in vitro by the serial dilution method. Many of these molecules displayed potent antibacterial and antifungal activities. The ease of synthesis from low-cost starting materials along with potent antimicrobial activity of these molecules provide the lead for further improvement of activity and reflect the possibility of therapeutic use.

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