scholarly journals Weight History, Smoking, Physical Activity and Breast Cancer Risk among French-Canadian Women Non-Carriers of More FrequentBRCA1/2Mutations

2009 ◽  
Vol 2009 ◽  
pp. 1-11 ◽  
Author(s):  
Vishnee Bissonauth ◽  
Bryna Shatenstein ◽  
Eve Fafard ◽  
Christine Maugard ◽  
André Robidoux ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Weight Gain ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Lifestyle Factors ◽  
Moderate Physical Activity ◽  
French Canadian ◽  
Weight History ◽  
Incident Cases

Several lifestyle factors play a significant role in determining an individual's risk of breast cancer. Many of them could be modified to protect against the malignancy. A nested case-control study was conducted to examine the association between selected lifestyle factors and non-BRCA-related breast cancer risk among French-Canadian women. Some 280 women with breast cancer and who were nongene carriers of mutatedBRCAgene were recruited as cases. Another 280 women, without any cancer and nongene carriers of mutatedBRCAgene served as controls. A tested lifestyle questionnaire was interviewer administered to incident cases to obtain information on weight history, smoking, physical activity, and other lifestyle risk factors. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in logistic regression models. Comparing cases to controls, breast cancer risk was higher among subjects who reached their maximum body mass index (BMI) at an older age (>50 years) (OR=2.83; 95% CI: 2.34–2.91). A positive association was noted between breast cancer risk and weight gain of>34 lbs compared to weight gain of≤15 lbs, since the age of 20 (OR=1.68; 95% CI: 1.10–2.58). Weight gain of>24 lbs compared to weight gain of≤9 lbs, since the age of 30 also resulted in the same relationship (OR=1.96; 95% CI: 1.46–3.06). Similarly, since the age of 40, weight gain of>12 lbs compared to weight gain of≤1 lb was associated with increased breast cancer risk (OR=1.91; 95% CI: 1.53–2.66). Women who smoked>9 pack-years of cigarettes had a 59% higher breast cancer risk (P=.05). Subjects who engaged in>24.8 metabolic-equivalent- (MET-) hours per week compared to≤10.7 MET-hours per week of moderate physical activity had a 52% (P=.01) decreased risk and total physical activity between 16.2 and 33.2 MET-hours per week compared to≤16.2 MET-hours per week, resulted in a 43% (P=.05) lower risk of breast cancer. In conclusion, weight history did affect breast cancer risk. Moreover, smoking appeared to raise the risk, whereas moderate physical activity had a protective effect.

scholarly journals Fat or fit: The joint effects of physical activity, weight gain, and body size on breast cancer risk

Cancer ◽  
2012 ◽  
Vol 118 (19) ◽  
pp. 4860-4868 ◽  
Author(s):  
Lauren E. McCullough ◽  
Sybil M. Eng ◽  
Patrick T. Bradshaw ◽  
Rebecca J. Cleveland ◽  
Susan L. Teitelbaum ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Body Size ◽  
Weight Gain ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Joint Effects

Moderate physical activity and breast cancer risk: the effect of menopausal status

2010 ◽  
Vol 21 (4) ◽  
pp. 577-586 ◽  
Author(s):  
Angélica Ángeles-Llerenas ◽  
Carolina Ortega-Olvera ◽  
Edelmiro Pérez-Rodríguez ◽  
Jesús Pablo Esparza-Cano ◽  
Eduardo Lazcano-Ponce ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Menopausal Status ◽  
Moderate Physical Activity

scholarly journals Household, Moderate Physical Activity and the Risk of Breast Cancer Among Nigerian Women: An Epidemiological Study

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 198s-198s
Author(s):  
S. Azubuike ◽  
R. McNally ◽  
L. Hayes
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Cancer Incidence ◽  
Physical Activities ◽  
Moderate Physical Activity ◽  
Nigerian Women ◽  
Daily Routines ◽  
Metabolic Equivalents

Background: Breast cancer incidence in Nigeria has risen by >120% since 2000. The mortality rate (25.9/100,000/yr) ranks highest in Africa. Inverse associations between household physical activities (PA) as well as moderate PA, and breast cancer risk have been suggested in literature. However, the roles of these activities in breast cancer risk have not been widely studied in Africa. As the socioeconomic status of many Nigerian women improves, their household and daily routines are expected to change. These have implications for their level of physical activity. Aim: The aim of this study was to investigate if there is an association between household, as well as moderate PA and breast cancer risk among Nigerian women. Methods: The study was a multisite hospital based case-control design involving 379 histologically confirmed breast cancer cases and 403 controls. The participants aged ≥ 20 years were interviewed in-person between October 2016 and May 2017 using a pretested questionnaire. Cases were selected from oncology wards and controls from ophthalmology wards. Self-reported household and moderate PA were summarized as both hours per week and metabolic equivalents (MET) hours per week (met-hr/wk). Data were analyzed using multivariable logistic regression, adjusting for known confounders. SPSS version 23 was used for all analyses. Results: The odd of having breast cancer (based on MET-hr/wk) was 40% less among women in the upper tertile of household PA than those in the lowest tertile (95% CI, 0.39-0.94). This was stronger among younger (OR: 0.50, 95% CI, 0.26-0.94), premenopausal (OR: 0.46; 95% CI, 0.24-0.89) and lean women (OR: 39, 95% CI, 0.16-0.87). Moderate PA was also associated with reduced breast cancer risk ( P = 0.04). Conclusion: The study suggested that household and moderate physical activities were protective of breast cancer among Nigerian women. Household chores and other routine moderate activities could provide opportunities for breast cancer prevention in Nigeria. Future studies could consider the use of community controls to authenticate the findings.

scholarly journals Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women

2015 ◽  
Vol 150 (3) ◽  
pp. 643-653 ◽  
Author(s):  
Bernard Rosner ◽  
A. Heather Eliassen ◽  
Adetunji T. Toriola ◽  
Susan E. Hankinson ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Weight Gain ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Hormone Receptor ◽  
Short Term

scholarly journals Modifiable Lifestyle Factors: Opportunities for (Hereditary) Breast Cancer Prevention - a Narrative Review

Breast Care ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. 108-113 ◽  
Author(s):  
Jacqueline Lammert ◽  
Sabine Grill ◽  
Marion Kiechle
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Healthy Lifestyle ◽  
Absolute Risk ◽  
Lifestyle Factors ◽  
Breast Cancer Prevention ◽  
The Impact

Increasing rates of obesity, lack of physical activity, sedentary behavior, and frequent alcohol consumption are major lifestyle-related risk factors for breast cancer. In fact, it has been estimated that about one-third of breast cancer cases are attributable to factors women can change. Most research has focused on examining the impact of one single exposure on breast cancer risk while adjusting for other risk modifiers. Capitalizing on big data, major efforts have been made to evaluate the combined impact of well-established lifestyle factors on overall breast cancer risk. At the individual level, data indicate that even simple behavior modifications could have a considerable impact on breast cancer prevention. Moreover, there is emerging new evidence that adopting a healthy lifestyle may be particularly relevant for women with hereditary susceptibility to breast cancer. On the absolute risk scale, studies suggest that the presence of certain risk factors, such as excessive body weight, had a substantially higher impact on breast cancer risk if women had a hereditary predisposition to cancer. The existing body of knowledge gives the medical professionals guidance as to which factors to focus on when counseling patients. However, well-designed randomized controlled trials utilizing objective methods are crucial to providing concrete recommendations.

Sign in / Sign up

Export Citation Format

Share Document