scholarly journals Household, Moderate Physical Activity and the Risk of Breast Cancer Among Nigerian Women: An Epidemiological Study

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 198s-198s
Author(s):  
S. Azubuike ◽  
R. McNally ◽  
L. Hayes
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Cancer Incidence ◽  
Physical Activities ◽  
Moderate Physical Activity ◽  
Nigerian Women ◽  
Daily Routines ◽  
Metabolic Equivalents

Background: Breast cancer incidence in Nigeria has risen by >120% since 2000. The mortality rate (25.9/100,000/yr) ranks highest in Africa. Inverse associations between household physical activities (PA) as well as moderate PA, and breast cancer risk have been suggested in literature. However, the roles of these activities in breast cancer risk have not been widely studied in Africa. As the socioeconomic status of many Nigerian women improves, their household and daily routines are expected to change. These have implications for their level of physical activity. Aim: The aim of this study was to investigate if there is an association between household, as well as moderate PA and breast cancer risk among Nigerian women. Methods: The study was a multisite hospital based case-control design involving 379 histologically confirmed breast cancer cases and 403 controls. The participants aged ≥ 20 years were interviewed in-person between October 2016 and May 2017 using a pretested questionnaire. Cases were selected from oncology wards and controls from ophthalmology wards. Self-reported household and moderate PA were summarized as both hours per week and metabolic equivalents (MET) hours per week (met-hr/wk). Data were analyzed using multivariable logistic regression, adjusting for known confounders. SPSS version 23 was used for all analyses. Results: The odd of having breast cancer (based on MET-hr/wk) was 40% less among women in the upper tertile of household PA than those in the lowest tertile (95% CI, 0.39-0.94). This was stronger among younger (OR: 0.50, 95% CI, 0.26-0.94), premenopausal (OR: 0.46; 95% CI, 0.24-0.89) and lean women (OR: 39, 95% CI, 0.16-0.87). Moderate PA was also associated with reduced breast cancer risk ( P = 0.04). Conclusion: The study suggested that household and moderate physical activities were protective of breast cancer among Nigerian women. Household chores and other routine moderate activities could provide opportunities for breast cancer prevention in Nigeria. Future studies could consider the use of community controls to authenticate the findings.

Physical activity and risk of postmenopausal breast cancer defined by hormone receptor status and histology: A large prospective cohort study with 18 years of follow up

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 1002-1002 ◽  
Author(s):  
A. Bardia ◽  
A. H. Wang ◽  
L. C. Hartmann ◽  
J. E. Olson ◽  
C. M. Vachon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Risk Factors ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Histological Subtypes

1002 Background: Physical activity is a modifiable breast cancer risk factor, perhaps mediating risk reduction through regulation of estrogen metabolism. Evidence regarding effect of physical activity is conflicting partly because breast cancer is a heterogenous constellation of different tumor subtypes with differing etiologies. No prospective study has examined the relationship between physical activity and breast cancer incidence based on ER/PR status or histological subtype. Objective: Examine effect of physical activity on breast cancer incidence based on ER/PR status and histological subtypes of breast cancer. Methods: The Iowa Women’s Health Study is a prospective cohort study of postmenopausal women (N=41,837). Physical activity was self-reported on baseline questionnaire, and three levels (high, medium and low) were defined. Breast cancer incidence, histologic subtype and ER/PR status, through 18 years of follow-up, were ascertained by linkage with the Iowa SEER Cancer Registry. Cox proportional hazards models were used to estimate multivariate relative risks (RRs) and 95% confidence intervals (CIs) of breast cancer, adjusting for other breast cancer risk factors. Results: During 554,819 person-years of follow-up, 2548 incident cases of breast cancer were observed. High physical activity was associated with decreased risk for breast cancer (RR 0.91, 95 % CI 0.81–1.01) compared to low activity. The protective effect was most marked in ER+/PR− (RR 0.66, CI 0.46–0.94), intermediate in ER−/PR− (RR 0.80, CI 0.56–1.15), weakest in ER+/PR+ (RR 0.94, CI 0.81–1.08), and elevated in ER-/PR+ (RR 1.42, CI 0.67–3.01) tumors. Higher physical activity was also associated with a decreased risk of invasive ductal/lobular carcinoma (RR 0.90, CI 0.80–1.02), but not with invasive breast cancer with a favorable histology (RR 1.19, CI 0.78–1.81). Conclusions: Higher physical activity was associated with a 10% decreased risk of breast cancer. Unexpectedly, risk reduction was most marked in PR- tumors, particularly ER+/PR-, and the more aggressive histologic forms. Further studies are needed to confirm these findings, and also evaluate other risk factors based on ER/PR status and histological subtypes. No significant financial relationships to disclose.

scholarly journals Weight History, Smoking, Physical Activity and Breast Cancer Risk among French-Canadian Women Non-Carriers of More FrequentBRCA1/2Mutations

2009 ◽  
Vol 2009 ◽  
pp. 1-11 ◽  
Author(s):  
Vishnee Bissonauth ◽  
Bryna Shatenstein ◽  
Eve Fafard ◽  
Christine Maugard ◽  
André Robidoux ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Weight Gain ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Lifestyle Factors ◽  
Moderate Physical Activity ◽  
French Canadian ◽  
Weight History ◽  
Incident Cases

Several lifestyle factors play a significant role in determining an individual's risk of breast cancer. Many of them could be modified to protect against the malignancy. A nested case-control study was conducted to examine the association between selected lifestyle factors and non-BRCA-related breast cancer risk among French-Canadian women. Some 280 women with breast cancer and who were nongene carriers of mutatedBRCAgene were recruited as cases. Another 280 women, without any cancer and nongene carriers of mutatedBRCAgene served as controls. A tested lifestyle questionnaire was interviewer administered to incident cases to obtain information on weight history, smoking, physical activity, and other lifestyle risk factors. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in logistic regression models. Comparing cases to controls, breast cancer risk was higher among subjects who reached their maximum body mass index (BMI) at an older age (>50 years) (OR=2.83; 95% CI: 2.34–2.91). A positive association was noted between breast cancer risk and weight gain of>34 lbs compared to weight gain of≤15 lbs, since the age of 20 (OR=1.68; 95% CI: 1.10–2.58). Weight gain of>24 lbs compared to weight gain of≤9 lbs, since the age of 30 also resulted in the same relationship (OR=1.96; 95% CI: 1.46–3.06). Similarly, since the age of 40, weight gain of>12 lbs compared to weight gain of≤1 lb was associated with increased breast cancer risk (OR=1.91; 95% CI: 1.53–2.66). Women who smoked>9 pack-years of cigarettes had a 59% higher breast cancer risk (P=.05). Subjects who engaged in>24.8 metabolic-equivalent- (MET-) hours per week compared to≤10.7 MET-hours per week of moderate physical activity had a 52% (P=.01) decreased risk and total physical activity between 16.2 and 33.2 MET-hours per week compared to≤16.2 MET-hours per week, resulted in a 43% (P=.05) lower risk of breast cancer. In conclusion, weight history did affect breast cancer risk. Moreover, smoking appeared to raise the risk, whereas moderate physical activity had a protective effect.

Moderate physical activity and breast cancer risk: the effect of menopausal status

2010 ◽  
Vol 21 (4) ◽  
pp. 577-586 ◽  
Author(s):  
Angélica Ángeles-Llerenas ◽  
Carolina Ortega-Olvera ◽  
Edelmiro Pérez-Rodríguez ◽  
Jesús Pablo Esparza-Cano ◽  
Eduardo Lazcano-Ponce ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Menopausal Status ◽  
Moderate Physical Activity

scholarly journals Aromatase and breast cancer susceptibility.

1999 ◽  
pp. 165-173 ◽  
Author(s):  
N M Probst-Hensch ◽  
S A Ingles ◽  
A T Diep ◽  
R W Haile ◽  
F Z Stanczyk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Latina Women ◽  
Repeat Polymorphism ◽  
Cyp19 Gene ◽  
Functional Relevance

Based on experimental and epidemiological evidence it is hypothesized that estrogen increases breast cancer risk by increasing mitotic activity in breast epithelial cells. Aromatase is crucial to the biosynthesis of estrogens and may therefore play a role in breast cancer development. Supporting data for an etiological role of aromatase in breast tumor biology are several-fold. First, the association between weight and postmenopausal breast cancer risk may be mediated by aromatase. Secondly, a pilot study found a higher aromatase expression in normal breast adipose tissue from breast cancer cases as opposed to healthy women. Thirdly, experimental data in animals suggest that aromatase activity predisposes mammary tissue to preneoplastic and neoplastic changes. In a multiethnic cohort study conducted in Los Angeles and on Hawaii we investigated (i) whether the plasma estrone to androstenedione (E1/A) ratio in different ethnic groups was associated with ethnic differences in breast cancer incidence, and (ii) whether genetic variation in the CYP19 gene encoding the P450 aromatase protein was associated with breast cancer risk. The age- and weight-adjusted ethnic specific E1/A ratios x 100 among women without oophorectomy were 7.92 in African-Americans, 8.22 in Japanese, 10.73 in Latinas and 9.29 in non-Latina Whites (P=0.09). The high E1/A ratio in Latina women was not associated with a high breast cancer incidence; in fact Latina women had the lowest breast cancer incidence in the cohort observed so far. We found no consistent association of an intronic (TTTA)n repeat polymorphism with breast cancer risk in different ethnic groups. This polymorphism was not associated with differences in the plasma E1/A ratio in a way that would predict its functional relevance. We describe a newly identified TTC deletion in intron 5 of the CYP19 gene that is associated with the (TTTA)n repeat polymorphism. Neither this polymorphism, nor a polymorphism at codon 264 in exon VII of the CYP19 gene, was associated with breast cancer. We did not identify any genetic variation in exon VIII in 54 African-American subjects. We identified rare genetic variants of unknown functional relevance in the promoter 1.4 of the CYP19 gene in 3 out of 24 Latina women. Further investigation into the role of aromatase in breast cancer etiology is important, given that the potential use of aromatase inhibitors as breast cancer chemopreventives depends on these results.

scholarly journals Sleep duration and breast cancer incidence: results from the Million Women Study and meta-analysis of published prospective studies

SLEEP ◽  
2020 ◽  
Author(s):  
Angel T Y Wong ◽  
Alicia K Heath ◽  
Tammy Y N Tong ◽  
Gillian K Reeves ◽  
Sarah Floud ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sleep Duration ◽  
Cancer Incidence ◽  
Prospective Studies ◽  
Average Duration ◽  
Meta Analysis ◽  
Breast Cancer Incidence ◽  
Weighted Average

Abstract Study Objectives To investigate the association between sleep duration and breast cancer incidence, we examined the association in a large UK prospective study and conducted a meta-analysis of prospective studies. Methods In the Million Women Study, usual sleep duration over a 24-h period was collected in 2001 for 713,150 participants without prior cancer, heart problems, stroke, or diabetes (mean age = 60 years). Follow-up for breast cancer was by record linkage to national cancer registry data for 14.3 years on average from the 3-year resurvey. Cox regression models yielded multivariable-adjusted breast cancer relative risks (RR) and 95% confidence intervals (CIs) for sleep duration categories. Published prospective studies of sleep duration and breast cancer risk were included in a meta-analysis, which estimated the inverse-variance weighted average of study-specific log RRs for short and for long versus average duration sleep. Results After excluding the first 5 years to minimize reverse causation bias in the Million Women Study, 24,476 women developed breast cancer. Compared with 7–8 h of sleep, the RRs for <6, 6, 9, and >9 h of sleep were 1.01 (95% CI, 0.95–1.07), 0.99 (0.96–1.03), 1.01 (0.96–1.06), and 1.03 (0.95–1.12), respectively. In a meta-analysis of 14 prospective studies plus the Million Women Study, including 65,410 breast cancer cases, neither short (RR < 7 h = 0.99 [0.98–1.01]) nor long (RR > 8 h = 1.01 [0.98–1.04]) versus average duration sleep was associated with breast cancer risk. Conclusions The totality of the prospective evidence does not support an association between sleep duration and breast cancer risk.

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