scholarly journals Fat or fit: The joint effects of physical activity, weight gain, and body size on breast cancer risk

Cancer ◽  
2012 ◽  
Vol 118 (19) ◽  
pp. 4860-4868 ◽  
Author(s):  
Lauren E. McCullough ◽  
Sybil M. Eng ◽  
Patrick T. Bradshaw ◽  
Rebecca J. Cleveland ◽  
Susan L. Teitelbaum ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Body Size ◽  
Weight Gain ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Joint Effects

Joint effects of body size, energy intake, and physical activity on breast cancer risk

2008 ◽  
Vol 113 (1) ◽  
pp. 153-161 ◽  
Author(s):  
Aesun Shin ◽  
Charles E. Matthews ◽  
Xiao-Ou Shu ◽  
Yu-Tang Gao ◽  
Wei Lu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Body Size ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Energy Intake ◽  
Joint Effects

scholarly journals Weight History, Smoking, Physical Activity and Breast Cancer Risk among French-Canadian Women Non-Carriers of More FrequentBRCA1/2Mutations

2009 ◽  
Vol 2009 ◽  
pp. 1-11 ◽  
Author(s):  
Vishnee Bissonauth ◽  
Bryna Shatenstein ◽  
Eve Fafard ◽  
Christine Maugard ◽  
André Robidoux ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Weight Gain ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Lifestyle Factors ◽  
Moderate Physical Activity ◽  
French Canadian ◽  
Weight History ◽  
Incident Cases

Several lifestyle factors play a significant role in determining an individual's risk of breast cancer. Many of them could be modified to protect against the malignancy. A nested case-control study was conducted to examine the association between selected lifestyle factors and non-BRCA-related breast cancer risk among French-Canadian women. Some 280 women with breast cancer and who were nongene carriers of mutatedBRCAgene were recruited as cases. Another 280 women, without any cancer and nongene carriers of mutatedBRCAgene served as controls. A tested lifestyle questionnaire was interviewer administered to incident cases to obtain information on weight history, smoking, physical activity, and other lifestyle risk factors. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in logistic regression models. Comparing cases to controls, breast cancer risk was higher among subjects who reached their maximum body mass index (BMI) at an older age (>50 years) (OR=2.83; 95% CI: 2.34–2.91). A positive association was noted between breast cancer risk and weight gain of>34 lbs compared to weight gain of≤15 lbs, since the age of 20 (OR=1.68; 95% CI: 1.10–2.58). Weight gain of>24 lbs compared to weight gain of≤9 lbs, since the age of 30 also resulted in the same relationship (OR=1.96; 95% CI: 1.46–3.06). Similarly, since the age of 40, weight gain of>12 lbs compared to weight gain of≤1 lb was associated with increased breast cancer risk (OR=1.91; 95% CI: 1.53–2.66). Women who smoked>9 pack-years of cigarettes had a 59% higher breast cancer risk (P=.05). Subjects who engaged in>24.8 metabolic-equivalent- (MET-) hours per week compared to≤10.7 MET-hours per week of moderate physical activity had a 52% (P=.01) decreased risk and total physical activity between 16.2 and 33.2 MET-hours per week compared to≤16.2 MET-hours per week, resulted in a 43% (P=.05) lower risk of breast cancer. In conclusion, weight history did affect breast cancer risk. Moreover, smoking appeared to raise the risk, whereas moderate physical activity had a protective effect.

scholarly journals Breast cancer risk and the interaction between adolescent body size and weight gain in later life: A case-control study

2016 ◽  
Vol 45 ◽  
pp. 135-144 ◽  
Author(s):  
Ines Florath ◽  
Danja Sarink ◽  
Christobel Saunders ◽  
Jane Heyworth ◽  
Lin Fritschi
Keyword(s):  
Breast Cancer ◽  
Body Size ◽  
Weight Gain ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Later Life ◽  
Case Control ◽  
Control Study

scholarly journals Genetic variants in the mTOR pathway and interaction with body size and weight gain on breast cancer risk in African-American and European American women

2016 ◽  
Vol 27 (8) ◽  
pp. 965-976 ◽  
Author(s):  
Ting-Yuan David Cheng ◽  
Jyoti Shankar ◽  
Gary Zirpoli ◽  
Michelle R. Roberts ◽  
Chi-Chen Hong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
African American ◽  
Body Size ◽  
Weight Gain ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Mtor Pathway ◽  
European American ◽  
American Women
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