LOSS OF PHOSPHOLIPID IN THE SKIN OF TUMOR-BEARING RATS

1959 ◽  
Vol 37 (1) ◽  
pp. 1447-1451
Author(s):  
Eldon M. Boyd ◽  
Irene E. Millar
Keyword(s):  
Significant Rise ◽  
Albino Rats ◽  
Cholesterol Esters ◽  
Tumor Bearing ◽  
Significant Fall

There occurs a unique, statistically significant fall in the level of phospholipid in the skin of albino rats bearing large Walker carcinosarcomata 256. The shift is similar to that produced by application of methylcholanthrene. It is preceded by loss of skin weight and increases in levels of skin water, cholesterol, and cholestrol esters. It is accompanied by loss of skin neutral fat and cholesterol esters. The quadratic shift in cholesterol esters occurs in hair before it occurs in skin, and is accompanied by a loss of hair weight and a slight but significant rise in levels of hair neutral fat. Declining levels of skin phospholipid may be part of the mechanism of production of the sallow appearance of the skin in late malignancy.

LOSS OF PHOSPHOLIPID IN THE SKIN OF TUMOR-BEARING RATS

1959 ◽  
Vol 37 (12) ◽  
pp. 1447-1451 ◽  
Author(s):  
Eldon M. Boyd ◽  
Irene E. Millar
Keyword(s):  
Significant Rise ◽  
Albino Rats ◽  
Cholesterol Esters ◽  
Tumor Bearing ◽  
Significant Fall

There occurs a unique, statistically significant fall in the level of phospholipid in the skin of albino rats bearing large Walker carcinosarcomata 256. The shift is similar to that produced by application of methylcholanthrene. It is preceded by loss of skin weight and increases in levels of skin water, cholesterol, and cholestrol esters. It is accompanied by loss of skin neutral fat and cholesterol esters. The quadratic shift in cholesterol esters occurs in hair before it occurs in skin, and is accompanied by a loss of hair weight and a slight but significant rise in levels of hair neutral fat. Declining levels of skin phospholipid may be part of the mechanism of production of the sallow appearance of the skin in late malignancy.

scholarly journals Beryllium Induced Biochemical Alterations in Rodent Model and its Treatment with Calcium Salt of Diethylene Triamine Penta Acetic Acid with α -tocopherol

2020 ◽  
Vol 6 (10) ◽  
pp. 137-142
Author(s):  
A. K. Upadhyay and S. P. Mishra
Keyword(s):  
Acetic Acid ◽  
Therapeutic Efficacy ◽  
Serum Alkaline Phosphatase ◽  
Significant Rise ◽  
Total Serum Protein ◽  
Total Serum ◽  
Albino Rats ◽  
Biochemical Alterations ◽  
Beneficial Effects ◽  
Significant Fall

To evaluate therapeutic efficacy of chelating agents tiron (Sodium-4,5- dihydroxy-1,3-benzene di-sulphonate) and CaNa3DTPA (Calcium tri-sodium di-ethylene tri-amine penta acetic acid) in presence of α-tocopherol against beryllium induced toxicity, adult female albino rats were exposed to beryllium nitrate for 28 days followed by therapy with tiron (471 mg/kg, ip) and CaNa3DTPA (35 mg/kg, ip) alone and in combination with α-tocopherol (25 mg/kg, po). Results revealed non-significant fall in hemoglobin and total serum protein content while significant fall in blood sugar level and activity of serum alkaline phosphatase. On the other hand, significant rise in the activity of serum transaminases and LDH was noticed after beryllium administration. Significant increase in total and esterified cholesterol was found in liver and kidney after toxicity. Significant increase in lipid peroxidation and decreased level of reduced glutathione in both the organs showed oxidative stress due to beryllium exposure. CaNa3DTPA showed moderate therapeutic efficacy; however, its effectiveness was enhanced with α-tocopherol to some extent. Tiron in combination with α-tocopherol exerted statistically more beneficial effects in reversal of beryllium induced biochemical alterations.

SIGNIFICANT CHANGES IN THE LIPID AND WATER CONTENT OF THE THYMUS GLAND IN ALBINO RATS BEARING WALKER CARCINOMA 256

1955 ◽  
Vol 33 (1) ◽  
pp. 69-82 ◽  
Author(s):  
Eldon M. Boyd ◽  
Valmore Fontaine ◽  
J. Gilbert Hill
Keyword(s):  
Fatty Acids ◽  
Tumor Growth ◽  
Total Lipid ◽  
Free Cholesterol ◽  
Dry Weight ◽  
Thymus Gland ◽  
Albino Rats ◽  
Tumor Bearing ◽  
Total Fatty Acids ◽  
Walker Carcinoma

The investigation was designed to measure hydrolipotropic variations in the thymus gland of albino rats bearing Walker carcinoma 256. This was done upon 27 pairs of littermate albino rats, one of each pair inoculated and one not inoculated with Walker carcinoma 256. The life history of the tumor was evenly represented in the series. Tumor growth was found to be accompanied by a statistically significant increase in total body weight, due to water retention, and decrease in the weight of the thymus gland. The total amount of water, dry weight, total lipid, neutral fat, total fatty acids, free cholesterol, and phospholipid were significantly less in the thymus gland of tumor-bearing albino rats. The concentrations, per unit dry weight, of total lipid, neutral fat, and total fatty acids in the thymus gland were not significantly affected by tumor growth. The similar concentrations of water, total cholesterol, free cholesterol, and phospholipid were significantly increased in the thymus gland of tumor-bearing albino rats. These changes indicated a hydrolipotropic effect of the tumor upon the thymus gland. A pyramidal, up-and-down, change in the concentrations of phospholipid and the three cholesterol fractions in the thymus gland at T/RC coefficients of 30 to 60, together with a marked loss of weight by the gland, suggested the effect upon the thymus gland of factor(s) other than the hydrolipotropic influence.

scholarly journals The effects of ursodeoxycholic acid in the management of sepsis-induced cholestasis in rodents

2019 ◽  
Author(s):  
Randa H. Ainosah ◽  
Magda M. Hagras ◽  
Sameer Alharthi ◽  
Omar I. Saadah
Keyword(s):  
Treatment Group ◽  
Bacterial Infection ◽  
Ursodeoxycholic Acid ◽  
Therapeutic Option ◽  
Flow Cytometric Analysis ◽  
Treated Group ◽  
Significant Rise ◽  
Albino Rats ◽  
Immunomodulatory Activity ◽  
Tnf Α

Abstract Background: Cholestasis is a condition in which there is impairment of bile flow from the liver to the small bowel. It is a common complication of bacterial infection and sepsis. Treatment is usually directed towards the eradication of bacterial infection and consequences of sepsis. Ursodeoxycholic acid (UDCA) has been under investigation as a possible therapeutic option for the treatments of sepsis-associated cholestasis.Methods: Sixty male albino rats (weighing 100–150g) were subjected to daily doses of UDCA (100 mg/kg, p.o.) for 10 days before or after lipopolysaccharides (LPS) induction of cholestasis. Then, the following liver enzyme activity was assessed: plasma aspartate transferase (AST), plasma alkaline transferase (ALT), plasma alkaline phosphatase (ALP), total bilirubin (TBIL). Hepatocyte apoptosis and immunomodulatory activity were assessed by flow cytometric analysis. Plasma pro-inflammatory cytokines (TNF-, IL-1 and IL-4) were measured by ELISA. Liver histology changes were assessed by hematoxylin and eosin (H&E) staining.Results: Our results showed that LPS-induced cholestasis resulted in a significant rise in the TBIL and liver enzymes including GGT, ALP, AST, and hepatocytes death. UDCA improves serum liver chemistries and halts bile acid cytotoxicity when it was used either as a treatment or prevention, compared to the LPS group. Moreover, UDCA has immunomodulatory properties: the effect of UDCA on the percentage of natural killer (NK) cells did not change in either the treatment or prevention group when compared to LPS induced cholestasis. However, significant decrease in the CD3 has been found in the treatment group as compared to the LPS group, and an unexpected increase in the prevention group compared to the LPS treated group. UDCA failed to ameliorate the increase in plasma TNF-α concentration in the treatment group. On the other hand, UDCA caused reduction in plasma TNF-α in the prevention group. We also found significant reduction in the liver tissue apoptosis in the UDCA treated groups. Conclusion: Prophylactic treatment and treatment with UDCA appear to exert a beneficial effect against the damaging effect of hydrophobic bile acids by LPS-induced secretary failure. This involved multiple mechanisms of action.

INFLUENCE OF DIETARY CHOLINE AND PROTEIN ON THE LEVEL OF PHOSPHOLIPID IN THE SERUM OF THE RAT

1957 ◽  
Vol 35 (1) ◽  
pp. 845-852 ◽  
Author(s):  
Bruno Rosenfeld ◽  
Jessie M. Lang
Keyword(s):  
Protein Content ◽  
Significant Rise ◽  
Albino Rats ◽  
Choline Deficiency ◽  
Serum Phospholipid ◽  
Liver Lipids ◽  
Total Liver ◽  
Dietary Choline

Albino rats weighing 180–200 g. were fed diets containing 5, 9, and 19% protein. The influence of these diets, both with and without additional choline, on the level of serum phospholipid was measured and it was found that only in the presence of dietary choline, an increase of the protein content of the diet caused an elevation of the level of phospholipid in the serum. Measurement of the effect of the interval after feeding showed a significant decrease of serum phospholipid 16 hours after the removal of the choline-containing food. In choline deficiency no such effect was found. Measurement of the influence of duration of choline deficiency on the level of phospholipid in serum revealed an immediate fall to a lower level at the onset of the deficiency. This change was complete before a significant rise of the level of total liver lipids was apparent.

In vivo phototoxic effects of a tetraethyleneglycol-substituted Zn phthalocyanine in tumor bearing rats at an enzymatic level

2020 ◽  
pp. A-H
Author(s):  
Muhammed Raşid Aykota ◽  
Sevda Yılmaz ◽  
Halil Erbiş ◽  
Nilgün Kabay ◽  
Sinem Tuncel Kostakoğlu ◽  
...  
Keyword(s):  
Albino Rats ◽  
Tetraethylene Glycol ◽  
Good Efficiency ◽  
Tumor Bearing ◽  
Oxidative Markers ◽  
Peripheral Position ◽  
Wistar Albino Rats

TEG-Pc, a Zn(II) phthalocyanine tetra substituted in non-peripheral position by tetraethylene glycol chains, proved to have good efficiency during in vitro photodynamic experiments. Its in vivo phototoxic effects have been investigated in tumor-bearing Wistar albino rats at an enzymatic level. The evolution of different oxidative markers are reviewed 6 h after the treatment.

scholarly journals Effects of low dose of aliskiren on isoproterenol-induced acute myocardial infarction in rats

2018 ◽  
Vol 105 (2) ◽  
pp. 127-144 ◽  
Author(s):  
I Bin-Jaliah ◽  
AM Hussein ◽  
HF Sakr ◽  
EA Eid
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Low Dose ◽  
Myocardial Damage ◽  
Significant Rise ◽  
Albino Rats ◽  
Cardiac Enzymes ◽  
St Segment Elevation ◽  
Direct Renin Inhibitor ◽  
Myocardial Oxidative Stress

This study examined the effects of aliskiren (Ali) (direct renin inhibitor) on serum cardiac enzymes (LDH and CK-MB), electrocardiography (ECG) changes, myocardial oxidative stress markers (MDA, CAT, and GSH) and the expression of Bcl2, HO-1, and Nrf2 genes in isoproterenol (ISO)-induced myocardial infarction (MI). A total of 40 male albino rats were allocated into four groups, (1) normal control (NC) group, (2) Ali group (rats received Ali at 10 mg/kg/day p.o. for 5 days), (3) ISO group (rats received ISO 150 mg/kg i.p. for two consecutive days at 24 h intervals), and (4) Ali + ISO group (rats received ISO + Ali at 10 mg/kg/day p.o. for 5 days from the 2nd dose of ISO). ISO group showed significant rise in serum cardiac enzymes (CK-MB and LDH), myocardial damage scores, myocardial MDA, HO-1, myocardial Nrf2 expression with significant reduction in myocardial antioxidants (CAT and GSH), and Bcl2 expression compared to the normal group (p < 0.05). ECG showed ST segment elevation, prolonged QT interval and QRS complex, and increased heart rate in ISO group. Co-administration of Ali and ISO caused significant increase in cardiac enzymes and morphology with increase in MDA, serum K, and creatinine with significant decrease in Bcl2, HO-1, and Nrf2 without significant changes in ECG parameters compared to ISO group. We concluded that low dose of Ali seems to exacerbate the myocardial injury in ISO-MI, which might be due to the enhanced oxidative stress and apoptosis.

Correction

PEDIATRICS ◽  
1963 ◽  
Vol 32 (1) ◽  
pp. 9-9
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Urinary Excretion ◽  
Mandelic Acid ◽  
Distress Syndrome ◽  
Environmental Temperature ◽  
Newborn Infants ◽  
Significant Rise ◽  
Urinary Output ◽  
Significant Fall

In the article entitled The Urinary Excretion of 3-methoxy-4-hydroxy-mandelic Acid (VMA) in Newborn Infants with the Respiratory Distress Syndrome, by J. J. Boehm and D. O'Brien (Pediatrics, 31:861, 1963), an error appears. On page 863 the sentence "Likewise, in 16 infants ages 4 to 9 days, there was a significant rise in the urinary output of VMA when the environmental temperature was raised from 75°F to 85°F." should read: "Likewise, in 16 infants ages 4 to 9 days, there was a significant fall in the urinary output of VMA when the environmental temperature was raised from 75°F to 85°F."

SIGNIFICANT CHANGES IN THE LIPID AND WATER CONTENT OF THE THYMUS GLAND IN ALBINO RATS BEARING WALKER CARCINOMA 256

1955 ◽  
Vol 33 (1) ◽  
pp. 69-82 ◽  
Author(s):  
Eldon M. Boyd ◽  
Valmore Fontaine ◽  
J. Gilbert Hill
Keyword(s):  
Fatty Acids ◽  
Tumor Growth ◽  
Total Lipid ◽  
Free Cholesterol ◽  
Dry Weight ◽  
Thymus Gland ◽  
Albino Rats ◽  
Tumor Bearing ◽  
Total Fatty Acids ◽  
Walker Carcinoma

The investigation was designed to measure hydrolipotropic variations in the thymus gland of albino rats bearing Walker carcinoma 256. This was done upon 27 pairs of littermate albino rats, one of each pair inoculated and one not inoculated with Walker carcinoma 256. The life history of the tumor was evenly represented in the series. Tumor growth was found to be accompanied by a statistically significant increase in total body weight, due to water retention, and decrease in the weight of the thymus gland. The total amount of water, dry weight, total lipid, neutral fat, total fatty acids, free cholesterol, and phospholipid were significantly less in the thymus gland of tumor-bearing albino rats. The concentrations, per unit dry weight, of total lipid, neutral fat, and total fatty acids in the thymus gland were not significantly affected by tumor growth. The similar concentrations of water, total cholesterol, free cholesterol, and phospholipid were significantly increased in the thymus gland of tumor-bearing albino rats. These changes indicated a hydrolipotropic effect of the tumor upon the thymus gland. A pyramidal, up-and-down, change in the concentrations of phospholipid and the three cholesterol fractions in the thymus gland at T/RC coefficients of 30 to 60, together with a marked loss of weight by the gland, suggested the effect upon the thymus gland of factor(s) other than the hydrolipotropic influence.

scholarly journals Study of Effect of Vitamin D Supplementation on Selected Hepatic and Renal Parameters in T2DM with Vitamin D Deficiency

2021 ◽  
Vol 14 (4) ◽  
pp. 1975-1982
Author(s):  
Deepali S Jankar ◽  
Kanchan C Wingkar ◽  
Ajit V Sontakke ◽  
Chintamani D Bodhe
Keyword(s):  
Vitamin D ◽  
Calcium Phosphate ◽  
Liver Enzymes ◽  
Vitamin D Supplementation ◽  
Significant Rise ◽  
Blood Levels ◽  
Significant Fall ◽  
Hepatic Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Introduction:- Vitamin D has been studied as modifiable risk factor in DM. Apart from its role in glucose homeostasis, the anti-inflammatory effect of vitamin D is claimed to have important effect on beta cell survival and on hepatic cells. Vitamin D is said to have anti-inflammatory, anti-proliferative and anti-fibrotic actions in liver. VDD is more prevalent in T2DM, obese and NAFLD even when these conditions occur separately. Literature states the protective effective of vitamin D on kidney. Association of VDD with albuminuria and chronic kidney disease in diabetics has also been reported. Material and Methods:- This is a type of comparative and interventional study. 63 T2DM patients aged 30 – 60 years with VDD were included. Baseline investigations determined blood levels of vitamin D, calcium, phosphate, liver enzymes (AST, ALT, ALP) and serum creatitine. Patients received vitamin D intervention orally in the dose of 2000 IU daily for 12 weeks. After 12 weeks blood levels of vitamin D, calcium, phosphate, liver enzymes (AST, ALT, ALP) and serum creatitine were determined. Results:- There was no correlation of vitamin D with urea, creatinine, calcium, phosphate, AST, ALT and ALP. There was extremely significant rise in vitamin D, significant fall in phosphate level, non-significant fall in creatinine, AST, ALT, ALP and non-significant rise in calcium, urea after 12 weeks of vitamin D supplementation. Conclusion:- There was no correlation of vitamin D with hepatic and renal parameters. Also 12 weeks of vitamin D supplementation had no significant improvement in these parameters in T2DM.

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