INFLUENCE OF DIETARY CHOLINE AND PROTEIN ON THE LEVEL OF PHOSPHOLIPID IN THE SERUM OF THE RAT

1957 ◽  
Vol 35 (1) ◽  
pp. 845-852 ◽  
Author(s):  
Bruno Rosenfeld ◽  
Jessie M. Lang
Keyword(s):  
Protein Content ◽  
Significant Rise ◽  
Albino Rats ◽  
Choline Deficiency ◽  
Serum Phospholipid ◽  
Liver Lipids ◽  
Total Liver ◽  
Dietary Choline

Albino rats weighing 180–200 g. were fed diets containing 5, 9, and 19% protein. The influence of these diets, both with and without additional choline, on the level of serum phospholipid was measured and it was found that only in the presence of dietary choline, an increase of the protein content of the diet caused an elevation of the level of phospholipid in the serum. Measurement of the effect of the interval after feeding showed a significant decrease of serum phospholipid 16 hours after the removal of the choline-containing food. In choline deficiency no such effect was found. Measurement of the influence of duration of choline deficiency on the level of phospholipid in serum revealed an immediate fall to a lower level at the onset of the deficiency. This change was complete before a significant rise of the level of total liver lipids was apparent.

INFLUENCE OF DIETARY CHOLINE AND PROTEIN ON THE LEVEL OF PHOSPHOLIPID IN THE SERUM OF THE RAT

1957 ◽  
Vol 35 (10) ◽  
pp. 845-852 ◽  
Author(s):  
Bruno Rosenfeld ◽  
Jessie M. Lang
Keyword(s):  
Protein Content ◽  
Significant Rise ◽  
Albino Rats ◽  
Choline Deficiency ◽  
Serum Phospholipid ◽  
Liver Lipids ◽  
Total Liver ◽  
Dietary Choline

Albino rats weighing 180–200 g. were fed diets containing 5, 9, and 19% protein. The influence of these diets, both with and without additional choline, on the level of serum phospholipid was measured and it was found that only in the presence of dietary choline, an increase of the protein content of the diet caused an elevation of the level of phospholipid in the serum. Measurement of the effect of the interval after feeding showed a significant decrease of serum phospholipid 16 hours after the removal of the choline-containing food. In choline deficiency no such effect was found. Measurement of the influence of duration of choline deficiency on the level of phospholipid in serum revealed an immediate fall to a lower level at the onset of the deficiency. This change was complete before a significant rise of the level of total liver lipids was apparent.

THE LIPOTROPIC ACTION OF COLD: 1. THE INFLUENCE OF COLD AND CHOLINE DEFICIENCY ON LIVER LIPIDS OF RATS AT DIFFERENT INTAKES OF DIETARY METHIONINE

1964 ◽  
Vol 42 (6) ◽  
pp. 769-777 ◽  
Author(s):  
M. W. Radomski ◽  
J. D. Wood
Keyword(s):  
Total Cholesterol ◽  
Cold Exposure ◽  
Free Cholesterol ◽  
Fatty Infiltration ◽  
Albino Rats ◽  
Dietary Intakes ◽  
Choline Deficiency ◽  
Liver Lipids ◽  
Cholesterol Levels

The effect of cold exposure and choline deficiency on the levels of liver lipids of male albino rats was studied at four dietary intakes of methionine (20–100 mg per rat per day). After exposure of the animals to cold (2–3 °C) for a 10-day period, the liver lipids were analyzed for total and free cholesterol, phospholipid, and triglyceride.In choline-fed animals, cold exposure did not affect triglyceride or total cholesterol levels but elevated phospholipid and free cholesterol and decreased ester cholesterol. The increase in phospholipid levels occurred at all methionine intakes with the changes in the cholesterol fractions occurring only at methionine intakes >40 mg per day.In choline-deficient rats, there was evidence that the lipotropic action of cold exposure was related to dietary methionine intake. At methionine intakes <60 mg per rat per day, fatty infiltration of the livers of the choline-deficient cold-exposed rats occurred, as evidenced by the accumulation of triglyceride and ester cholesterol. Concomitantly, phospholipid levels decreased. The data suggest that cold increases the capacity of the animal to synthesize choline from endogenous sources.

THE EFFECTS OF CHOLINE DEFICIENCY AND CHOLINE RE-FEEDING UPON THE METABOLISM OF PLASMA AND LIVER LIPIDS

1966 ◽  
Vol 44 (1) ◽  
pp. 45-57 ◽  
Author(s):  
D. S. M. Haines
Keyword(s):  
Lipid Metabolism ◽  
Fatty Liver ◽  
Palmitic Acid ◽  
Phosphatidyl Choline ◽  
Marked Reduction ◽  
Phosphatidyl Ethanolamine ◽  
Choline Deficiency ◽  
Liver Lipids ◽  
Dietary Choline ◽  
Plasma And Liver Lipids

The disturbance in lipid metabolism caused by deficiency of dietary choline in rats was investigated with H3-palmitic acid as a tracer. The incorporation of radioactivity into blood triglycerides, as compared to that in choline-supplemented controls, showed a striking decline in rats taken at intervals during the development of choline deficiency. This was partially corrected by choline re-feeding for 2 days and was normal after 4 days of choline re-feeding. Both the total amounts and the radioactivities of phosphatidyl choline in the liver and total phospholipids in the plasma were reduced in choline deficiency and were restored by choline re-feeding, whereas phosphatidyl ethanolamine in the liver was not affected. The findings confirm that the fatty liver of choline deficiency is the result of an impairment in the transport of triglyceride from the liver, and support the hypothesis that it occurs because of a restriction in the synthesis of phosphatidyl choline which is required for lipoprotein formation.A marked reduction in the transformation of14C-ethanolamine into phosphatidyl choline was evident in choline deficiency, but most of the increase in liver phosphatidyl choline which occurred subsequent to choline re-feeding appeared to be from synthesis by the direct (CDP-choline) pathway.

LOSS OF PHOSPHOLIPID IN THE SKIN OF TUMOR-BEARING RATS

1959 ◽  
Vol 37 (1) ◽  
pp. 1447-1451
Author(s):  
Eldon M. Boyd ◽  
Irene E. Millar
Keyword(s):  
Significant Rise ◽  
Albino Rats ◽  
Cholesterol Esters ◽  
Tumor Bearing ◽  
Significant Fall

There occurs a unique, statistically significant fall in the level of phospholipid in the skin of albino rats bearing large Walker carcinosarcomata 256. The shift is similar to that produced by application of methylcholanthrene. It is preceded by loss of skin weight and increases in levels of skin water, cholesterol, and cholestrol esters. It is accompanied by loss of skin neutral fat and cholesterol esters. The quadratic shift in cholesterol esters occurs in hair before it occurs in skin, and is accompanied by a loss of hair weight and a slight but significant rise in levels of hair neutral fat. Declining levels of skin phospholipid may be part of the mechanism of production of the sallow appearance of the skin in late malignancy.

scholarly journals Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus

2010 ◽  
Vol 107 (29) ◽  
pp. 12834-12839 ◽  
Author(s):  
M. G. Mehedint ◽  
C. N. Craciunescu ◽  
S. H. Zeisel
Keyword(s):  
Choline Deficiency ◽  
Fetal Mouse ◽  
Mouse Hippocampus ◽  
Dietary Choline
Sign in / Sign up

Export Citation Format

Share Document