Synthesis of glycosylated cationic porphyrins as potential agents in photodynamic therapy

1996 ◽  
Vol 74 (8) ◽  
pp. 1550-1563 ◽  
Author(s):  
Khalid Driaf ◽  
Robert Granet ◽  
Pierre krausz ◽  
Mourad Kaouadji ◽  
Bernard Verneuil ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Key Words ◽  
Propionic Acid ◽  
Cationic Porphyrins ◽  
New Class ◽  
Glycosylated Porphyrins

Trisalkylpyridinium porphyrins substituted by one glycosyl (glucosyl, maltosyl, and lactosyl) moiety have been prepared in acceptable yields. These glycosylated cationic porphyrins have been synthesized from pyrrole condensed with 4-pyridinecarboxaldehyde, and suitable ortho- or para peracetylglycosyloxybenzaldehyde derivatives in refluxing propionic acid –Ac2O followed by action of alkyliodide in DMF. Deprotection of the glycosylated moieties led to a new class of representative glycosylated porphyrins. Key words: porphyrins, cationic, glycosylated; phototherapy, cancer.

scholarly journals Encapsulation of glycosylated porphyrins in silica nanoparticles to enhance the efficacy of cancer photodynamic therapy

2021 ◽  
Author(s):  
Wioleta Borzęcka ◽  
Patrícia M. R. Pereira ◽  
Rosa Fernandes ◽  
Tito Trindade ◽  
Tomás Torres ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Silica Nanoparticles ◽  
Glycosylated Porphyrins

Encapsulation of glycosylated porphyrins in silica nanoparticles enhanced the efficacy of cancer photodynamic therapy compared with the free porphyrins.

EFFECT OF INTRARUMINAL INFUSION OF PROPIONIC ACID ON PLASMA METABOLITES IN GOATS

1984 ◽  
Vol 64 (5) ◽  
pp. 295-297 ◽  
Author(s):  
B. EMMANUEL ◽  
J. J. KENNELLY
Keyword(s):  
Key Words ◽  
Propionic Acid ◽  
Plasma Glucose ◽  
Milk Fat ◽  
Plasma Metabolites ◽  
Data Support

Effects of intraruminal infusion of propionic acid at 5.5 and 13.7 g/h on plasma metabolites have been investigated in goats fed a concentrate-roughage ration at 2-h intervals. Propionic acid increased plasma glucose and insulin concentrations, but did not change those of lactate, D(−)-3-hydroxybutyrate and prolactin. Data support the glucogenic theory in relation to low milk fat syndrome. Key words: Metabolites, plasma, goats, propionic acid

scholarly journals New Class of Homoleptic and Heteroleptic Bis(terpyridine) Iridium(III) Complexes with Strong Photodynamic Therapy Effects

2019 ◽  
Vol 2 (7) ◽  
pp. 2964-2977 ◽  
Author(s):  
Bingqing Liu ◽  
Susan Monro ◽  
Zhike Li ◽  
Mohammed A. Jabed ◽  
Daniel Ramirez ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
New Class

scholarly journals New cyclometalated Ir(iii) complexes with NCN pincer and meso-phenylcyanamide BODIPY ligands as efficient photodynamic therapy agents

RSC Advances ◽  
2017 ◽  
Vol 7 (54) ◽  
pp. 34160-34169 ◽  
Author(s):  
Leila Tabrizi ◽  
Hossein Chiniforoshan
Keyword(s):  
Photodynamic Therapy ◽  
New Class

A new class of cyclometalated iridium(iii) with NCN pincer andmeso-phenylcyanamide BODIPY ligands has been synthesized and studied for photodynamic therapy.

scholarly journals СИНТАКСОНОМІЯ УГРУПОВАНЬ ДРІБНОЛИСТЯНИХ ЛІСІВ НА ЗАРОСТАЮЧИХ ПЕРЕЛОГАХ

2015 ◽  
Vol 5 (02) ◽  
pp. 54
Author(s):  
E. O. Vorobyov ◽  
M. P. Olijnyk ◽  
I. V. Solomakha
Keyword(s):  
Key Words ◽  
New Associations ◽  
New Class ◽  
Small Leaf

<p>The spontaneous small leaf particles groups of fallows, that are the first stage of the restoration of broad-leaved forests were investigated. In composition of groups of birch, aspen and alder saplings on the fallows (Ivano-Frankivsk and Zhytomyr region) three new associations are distinguished and described (Cirsio arvensi-Betuletum pendulae, Phalacrolomo annui-Populetum tremulae, Dauco carotae-Alnetum glutinosae). These syntaxons are included into new class Dactylo glomerati-Populetea tremulae Vorobyov et I. Solomakha cl. nova in press. Syntaxonomy of this class was generalized for the territory of Ukraine.</p> <p><em>Key words: Syntaxonomy, class Dactylo glomerati-Populetea tremulae, fallows, afforestation, birch aspen and alder forests, Ukraine.</em></p>

scholarly journals Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)

2017 ◽  
Vol 53 (12) ◽  
pp. 2009-2012 ◽  
Author(s):  
Jordan Atchison ◽  
Sukanta Kamila ◽  
Heather Nesbitt ◽  
Kieran A. Logan ◽  
Dean M Nicholas ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cyanine Dyes ◽  
Cyanine Dye ◽  
New Class

Iodinated cyanine dye 6a has been developed for use as a NIR excited photosensitiser in photodynamic therapy.

METHOD DEVELOPMENT AND DETERMINATION OF PROPIONIC ACID IN FOODS IN HUE CITY

2019 ◽  
pp. 13-18
Author(s):  
Viet Khan Nguyen ◽  
Thi Hoai Nguyen
Keyword(s):  
Key Words ◽  
Propionic Acid ◽  
Method Development ◽  
Food Samples ◽  
Hplc Method ◽  
Optimal Process ◽  
Food Preservative ◽  
System Suitability ◽  
Precision And Accuracy

Background: Propionic acid (PRO) is increasingly being used as a food preservative on markets, today. However, excessive use of this chemical will harm the health of consumers. Objectives: (1) To develope an HPLC method for quantification of PRO in foods and (2) To determinate PRO content in some foods in Hue city. Materials and methods: Breads, cakes, noodles in Hue city. After attaining the optimal process, the method was validated and applied to assess the content of PRO in these materials. Results: The method was validated parameters including: system suitability, specificity, linearity, precision and accuracy. Conclusions: The method development canbe aplied to determine PRO in some foods. PRO contents (using as a preservative) in all foods surveyed in Hue city were under the permitted level of PRO in foods according to Ministry of Health (Vietnam). Key words: propionic acid, food samples, HPLC, content, derivatization

Photophysical, photooxidation, and biomolecule-interaction of meso-tetra(thienyl)porphyrins containing peripheral Pt(II) and Pd(II) complexes. Insights for photodynamic therapy applications

2022 ◽  
Author(s):  
Isadora Tisoco ◽  
Maria Carolina Donatoni ◽  
Henrique Victória ◽  
José Roberto de Toledo ◽  
Klaus Krambrock ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Elemental Analysis ◽  
Synthesis And Characterization ◽  
Polypyridyl Complexes ◽  
Cationic Porphyrins ◽  
Peripheral Position

We report the synthesis and characterization of two novel tetra-cationic porphyrins, containing Pt(II) or Pd(II) polypyridyl complexes attached at the peripheral position of N4-macrocycle. Compounds were characterized through elemental analysis,...

Synthesis and biological evaluation of polyamine-porphyrin conjugates as potential agents in photodynamic therapy (PDT)

2002 ◽  
Vol 06 (02) ◽  
pp. 130-134 ◽  
Author(s):  
François Lamarche ◽  
Vincent Sol ◽  
Yi-Ming Huang ◽  
Robert Granet ◽  
Michel Guilloton ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Biological Evaluation ◽  
Myelogenous Leukemia ◽  
Leukemia Cells ◽  
Malignant Cells ◽  
Photofrin Ii ◽  
New Class ◽  
Human Chronic Myelogenous Leukemia ◽  
Chronic Myelogenous Leukemia Cells ◽  
Synthesis And Biological Evaluation

A new class of porphyrins bearing natural polyamines has been designed in order to target the photosensitizers towards malignant cells. We report here the synthesis of spermidine and spermine porphyrins. The photocytotoxicity of these compounds against K562 human chronic myelogenous leukemia cells has been evaluated and compared to Photofrin II®.

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