scholarly journals Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)

2017 ◽  
Vol 53 (12) ◽  
pp. 2009-2012 ◽  
Author(s):  
Jordan Atchison ◽  
Sukanta Kamila ◽  
Heather Nesbitt ◽  
Kieran A. Logan ◽  
Dean M Nicholas ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cyanine Dyes ◽  
Cyanine Dye ◽  
New Class

Iodinated cyanine dye 6a has been developed for use as a NIR excited photosensitiser in photodynamic therapy.

scholarly journals Potential of Cyanine Derived Dyes in Photodynamic Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 818
Author(s):  
Natalia Lange ◽  
Wojciech Szlasa ◽  
Jolanta Saczko ◽  
Agnieszka Chwiłkowska
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Meta Analysis ◽  
Aqueous Media ◽  
Cyanine Dyes ◽  
Cyanine Dye ◽  
Structural Modifications ◽  
Squaraine Dyes ◽  
Metal Atoms ◽  
Diagnostic Agent

Photodynamic therapy (PDT) is a method of cancer treatment that leads to the disintegration of cancer cells and has developed significantly in recent years. The clinically used photosensitizers are primarily porphyrin, which absorbs light in the red spectrum and their absorbance maxima are relatively short. This review presents group of compounds and their derivatives that are considered to be potential photosensitizers in PDT. Cyanine dyes are compounds that typically absorb light in the visible to near-infrared-I (NIR-I) spectrum range (750–900 nm). This meta-analysis comprises the current studies on cyanine dye derivatives, such as indocyanine green (so far used solely as a diagnostic agent), heptamethine and pentamethine dyes, squaraine dyes, merocyanines and phthalocyanines. The wide array of the cyanine derivatives arises from their structural modifications (e.g., halogenation, incorporation of metal atoms or organic structures, or synthesis of lactosomes, emulsions or conjugation). All the following modifications aim to increase solubility in aqueous media, enhance phototoxicity, and decrease photobleaching. In addition, the changes introduce new features like pH-sensitivity. The cyanine dyes involved in photodynamic reactions could be incorporated into sets of PDT agents.

scholarly journals New Class of Homoleptic and Heteroleptic Bis(terpyridine) Iridium(III) Complexes with Strong Photodynamic Therapy Effects

2019 ◽  
Vol 2 (7) ◽  
pp. 2964-2977 ◽  
Author(s):  
Bingqing Liu ◽  
Susan Monro ◽  
Zhike Li ◽  
Mohammed A. Jabed ◽  
Daniel Ramirez ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
New Class

Reversal in Solvatochromism: AnET(30) Switch for a New Class of Cyanine Dyes

1996 ◽  
Vol 69 (9) ◽  
pp. 2581-2584 ◽  
Author(s):  
Bijay K. Mishra ◽  
Minati Kuanar ◽  
Amaresh Mishra ◽  
Gopa B. Behera
Keyword(s):  
Cyanine Dyes ◽  
New Class

scholarly journals Corrigendum: Pyrrolopyrrole Cyanine Dyes: A New Class of Near-Infrared Dyes and Fluorophores

2012 ◽  
Vol 18 (24) ◽  
pp. 7326-7326 ◽  
Author(s):  
Georg M. Fischer ◽  
Magnus Isomäki-Krondahl ◽  
Inigo Göttker-Schnetmann ◽  
Ewald Daltrozzo ◽  
Andreas Zumbusch
Keyword(s):  
Near Infrared ◽  
Cyanine Dyes ◽  
New Class

scholarly journals Cancer-mitochondria-targeted photodynamic therapy with supramolecular assembly of HA and a water soluble NIR cyanine dye

2017 ◽  
Vol 8 (12) ◽  
pp. 8351-8356 ◽  
Author(s):  
Ajesh P. Thomas ◽  
L. Palanikumar ◽  
M. T. Jeena ◽  
Kibeom Kim ◽  
Ja-Hyoung Ryu
Keyword(s):  
Photodynamic Therapy ◽  
Supramolecular Assembly ◽  
Water Soluble ◽  
Cyanine Dye ◽  
Targeted Photodynamic Therapy

Herein, we introduce an indocyanine derivative (IR-Pyr) that is highly water soluble, exhibiting higher mitochondrial targetability and better photostability than IR-780.

scholarly journals Measurement of Cyanine Dye Photobleaching in Photosensitizer Cyanine Dye Conjugates Could Help in Optimizing Light Dosimetry for Improved Photodynamic Therapy of Cancer

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1842 ◽  
Author(s):  
Nadine James ◽  
Ravindra Cheruku ◽  
Joseph Missert ◽  
Ulas Sunar ◽  
Ravindra Pandey
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Tumor Response ◽  
Cyanine Dye ◽  
Fluence Rate ◽  
Low Light ◽  
Light Dosimetry ◽  
Light Fluence ◽  
Photodynamic Therapy Of Cancer

Photodynamic therapy (PDT) of cancer is dependent on three primary components: photosensitizer (PS), light and oxygen. Because these components are interdependent and vary during the dynamic process of PDT, assessing PDT efficacy may not be trivial. Therefore, it has become necessary to develop pre-treatment planning, on-line monitoring and dosimetry strategies during PDT, which become more critical for two or more chromophore systems, for example, PS-CD (Photosensitizer-Cyanine dye) conjugates developed in our laboratory for fluorescence-imaging and PDT of cancer. In this study, we observed a significant impact of variable light dosimetry; (i) high light fluence and fluence rate (light dose: 135 J/cm2, fluence rate: 75 mW/cm2) and (ii) low light fluence and fluence rate (128 J/cm2 and 14 mW/cm2 and 128 J/cm2 and 7 mW/cm2) in photobleaching of the individual chromophores of PS-CD conjugates and their long-term tumor response. The fluorescence at the near-infrared (NIR) region of the PS-NIR fluorophore conjugate was assessed intermittently via fluorescence imaging. The loss of fluorescence, photobleaching, caused by singlet oxygen from the PS was mapped continuously during PDT. The tumor responses (BALB/c mice bearing Colon26 tumors) were assessed after PDT by measuring tumor sizes daily. Our results showed distinctive photobleaching kinetics rates between the PS and CD. Interestingly, compared to higher light fluence, the tumors exposed at low light fluence showed reduced photobleaching and enhanced long-term PDT efficacy. The presence of NIR fluorophore in PS-CD conjugates provides an opportunity of fluorescence imaging and monitoring the photobleaching rate of the CD moiety for large and deeply seated tumors and assessing PDT tumor response in real-time.

scholarly journals Photosensitizer (PS)-cyanine dye (CD) conjugates: Impact of the linkers joining the PS and CD moieties and their orientation in tumor-uptake and photodynamic therapy (PDT)

2016 ◽  
Vol 122 ◽  
pp. 770-785 ◽  
Author(s):  
Nadine S. James ◽  
Penny Joshi ◽  
Tymish Y. Ohulchanskyy ◽  
Yihui Chen ◽  
Walter Tabaczynski ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cyanine Dye ◽  
Tumor Uptake

scholarly journals New cyclometalated Ir(iii) complexes with NCN pincer and meso-phenylcyanamide BODIPY ligands as efficient photodynamic therapy agents

RSC Advances ◽  
2017 ◽  
Vol 7 (54) ◽  
pp. 34160-34169 ◽  
Author(s):  
Leila Tabrizi ◽  
Hossein Chiniforoshan
Keyword(s):  
Photodynamic Therapy ◽  
New Class

A new class of cyclometalated iridium(iii) with NCN pincer andmeso-phenylcyanamide BODIPY ligands has been synthesized and studied for photodynamic therapy.

Cyanine Dyes as a New Class of DNA Minor Groove Binders

2000 ◽  
Vol 28 (5) ◽  
pp. A464-A464
Author(s):  
A.L. Mikheikin ◽  
A.L. Zhuze ◽  
A.S. Zasedatelev
Keyword(s):  
Cyanine Dyes ◽  
Minor Groove ◽  
Dna Minor Groove ◽  
New Class ◽  
Minor Groove Binders ◽  
Groove Binders

scholarly journals J-Aggregates of Cyanine Dyes in Aqueous Solution of Polymers: A Quantitative Study

2004 ◽  
Vol 3 (3) ◽  
Author(s):  
Wesley Tillmann ◽  
Hussein Samha
Keyword(s):  
Aqueous Solution ◽  
Quantitative Study ◽  
Aggregation Number ◽  
Cyanine Dyes ◽  
Cyanine Dye ◽  
Isosbestic Point ◽  
Maximum Capacity ◽  
Vis Spectroscopy ◽  
J Aggregates

The effect of polyvinylsulfate (PVS) on the spectroscopy of the cyanine dye, 1,1’-diethyl-2,2’-cyanine iodide (PIC), has been investigated using UV-vis spectroscopy. J-aggregates of the PIC dye were formed upon addition of PVS to the monomers of the dye in solution. The appearance of only one isosbestic point in the UV-vis spectra suggests that the dye monomers are quantitatively converted to J-aggregates and equilibrium was reached. Using Benisi-Hildebrand kinetics, aggregation number of 4 was calculated for the dye. In addition, a 1:2 mole ratio of PIC/PVS was calculated at the maximum capacity of the polymer.

Sign in / Sign up

Export Citation Format

Share Document