The reduction of SU-4885 by adrenal glands and other tissues and its inhibition by ACTH

1968 ◽  
Vol 46 (5) ◽  
pp. 463-469 ◽  
Author(s):  
I. Kraulis ◽  
H. Traikov ◽  
M. P. Li ◽  
C. P. Lantos ◽  
M. K. Birmingham
Keyword(s):  
Rat Liver ◽  
Incubation Medium ◽  
Liver Tissue ◽  
Adrenal Glands ◽  
Rat Kidney ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
And Chemical Properties

Rat adrenal glands convert 2-methyl-1,2-bis(3-pyridyl)-1-propanone (SU-4885) in vitro to a product with physical and chemical properties indicating the reduction to 2-methyl-1,2-bis(3-pyridyl)-1-propanol. The same compound is also formed by the reduction of SU-4885 with NaBH4. The reduction of SU-4885 also occurs in the presence of frog adrenal, rat kidney, and most actively, rat liver tissue, and depends on the concentration of SU-4885 in the incubation medium. Added deoxycorticosterone, at the concentration used, had no effect, but ACTH inhibited the reduction by both adrenal and liver tissue.

Phenylalanine 4-monooxygenase from bovine and rat liver: Some physical and chemical properties

1982 ◽  
Vol 7 (4) ◽  
pp. 407-421 ◽  
Author(s):  
Anne D�skeland ◽  
Torbj�rn Ljones ◽  
Tore Skotland ◽  
Torgeir Flatmark
Keyword(s):  
Rat Liver ◽  
Chemical Properties ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
And Chemical Properties

First insights into the biochemistry ofSabella spallanzanii(Annelida: Polychaeta) mucus: a potentially unexplored resource for applicative purposes

2010 ◽  
Vol 91 (1) ◽  
pp. 199-208 ◽  
Author(s):  
Loredana Stabili ◽  
Roberto Schirosi ◽  
Angela Di Benedetto ◽  
Alessandro Merendino ◽  
Luciano Villanova ◽  
...  
Keyword(s):  
Marine Invertebrates ◽  
Vibrio Anguillarum ◽  
Chemical Properties ◽  
Dry Weight ◽  
Physical And Chemical Properties ◽  
Total Lipids ◽  
And Function ◽  
Physical And Chemical ◽  
And Chemical Properties

Although mucus plays many different roles among marine invertebrates, relatively little is known about the link between biochemical structure and function. In the present study we focused on some physical and chemical properties of the polychaeteSabella spallanzanii's mucus such as viscosity, osmolarity, electrical conductivity, elemental composition, the protein and carbohydrate content, the total lipids and fatty acid composition, and polychlorinated biphenyls (PCBs) contamination. Moreover, an antimicrobial activity of the mucus was investigated. The water content ofS. spallanzaniimucus was 96.2±0.3%. By dry weight 26±1.2% was protein, 8±0.21% was carbohydrate and only 0.1% lipid, much of the remainder of the dry weight was inorganic (about 65.2%). The estimated PCBs content was <0.005 μg g−1. The mucus ofS. spallanzaniiexerted a natural lysozyme-like activity and producedin vitrothe growth inhibition ofVibrio anguillarum, Vibrio harveyi, Pseudomonas aeruginosaandCandida albicans.The findings from this study contribute to improve the limited knowledge available on the mucus composition in invertebrates and have implications for future investigations related to employment ofS. spallanzaniimucus as a source of compounds of pharmaceutical and marine technological interest.

A broad-spectrum antibiotic produced by a species of Cryptosporiopsis

1969 ◽  
Vol 15 (6) ◽  
pp. 501-507 ◽  
Author(s):  
M. A. Stillwell ◽  
F. A. Wood ◽  
G. M. Strunz
Keyword(s):  
Staphylococcus Aureus ◽  
Chemical Properties ◽  
Growth Inhibitor ◽  
Molecular Formula ◽  
Physical And Chemical Properties ◽  
Broad Spectrum Antibiotic ◽  
Imperfect Fungus ◽  
Physical And Chemical ◽  
And Chemical Properties

A growth inhibitor with the molecular formula C10H10O4Cl2 was isolated from a medium which had supported growth of a species of Cryptosporiopsis, an imperfect fungus. The compound was named cryptosporiopsin and was characterized on the basis of its physical and chemical properties. Cryptosporiopsin was active in vitro against many wood-rotting basidiomycetes as well as some phycomycetes, ascomycetes, and deuteromycetes. It was more effective than Dithane M-22 or nystatin against the in vitro spore germination of Phytophthora infestans. It was active to varying degrees against six species of bacteria. Cryptosporiopsin was compared with Orbenin and streptomycin against a penicillin-resistant strain of Staphylococcus aureus.

Efficacy, safety, and physicochemical properties of a flowable hemostatic agent made from absorbable gelatin sponge via vacuum pressure steam sterilization

2020 ◽  
pp. 088532822095089
Author(s):  
Yuanxing Zhou ◽  
Xiaochi Ma ◽  
Zhonghai Li ◽  
Bo Wang
Keyword(s):  
Chemical Properties ◽  
Erythrocyte Aggregation ◽  
Hemostatic Agent ◽  
Gelatin Sponge ◽  
Toxicity Tests ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
And Chemical Properties

An effective and viable hemostatic agent is important for stopping bleeding during surgery. However, it is difficult to achieve hemostasis at uneven or deep bleeding sites using a gelatin sponge. A flowable hemostatic agent has therefore been developed by processing and improving gelatin sponge, to address bleeding under these conditions. In this study, we evaluated the efficacy, safety, and physical and chemical properties of this flowable hemostatic agent in various experiments. We examined its efficacy for stopping bleeding in a rabbit model of liver abrasion in vivo, and compared its efficacy in dynamic coagulation and erythrocyte aggregation tests with gelatin sponge in vitro. We also investigated its safety in rat histocompatibility and acute systemic toxicity tests in mice in vivo, and in hemolysis tests in vitro, to determine if the flowable hemostatic agent induced any pathological reactions or adverse events. In terms of its physical and chemical properties, we analyzed the morphology and chemical bonds of the flowable hemostatic agent by optical and electron microscopy and infrared spectroscopy, and its absorbency and density. The flowable hemostatic agent resulted in a shorter mean bleeding time, less bleeding, greater likelihood of successful hemostasis, and reduced clotting time compared with gelatin sponge. The flowable agent produced some changes in physical morphology, but no pathological changes or undesirable outcomes were detected. This flowable topical hemostatic agent thus provides a safe and more effective hemostatic method than gelatin sponge, and more promising results for intraoperative hemostasis, especially on uneven or deep bleeding surfaces.

scholarly journals 14α-Hydroxyoestrone, a new oestrogen metabolite

1967 ◽  
Vol 105 (3) ◽  
pp. 971-978 ◽  
Author(s):  
R. Knuppen ◽  
O. Haupt ◽  
H. Breuer
Keyword(s):  
Adrenal Glands ◽  
Chemical Properties ◽  
Crystalline Form ◽  
Physical And Chemical Properties ◽  
Physical And Chemical ◽  
And Chemical Properties

1. Incubation of oestrone with ox adrenal glands leads to the formation of two main metabolites, one of which has recently been identified as 15α-hydroxyoestrone; the second metabolite (Oe-5) has now been obtained in crystalline form and identified as the hitherto unknown 14α-hydroxyoestrone. 2. The identity of compound Oe-5 with 14α-hydroxyoestrone was confirmed conclusively by comparison with 14α-hydroxyoestrone that was synthesized by pyrolytic aromatization of 14α-hydroxyandrosta-1,4-diene-3,17-dione. 3. The physical and chemical properties as well as the oestrogenic activity of 14α-hydroxyoestrone are described. 4. The biogenesis and metabolism of 14α-hydroxyoestrone were studied in various tissue preparations.

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