scholarly journals Churg-Strauss vasculitis presenting with severe visual loss due to bilateral sequential optic neuropathy.

1993 ◽  
Vol 77 (2) ◽  
pp. 118-119 ◽  
Author(s):  
J F Acheson ◽  
O C Cockerell ◽  
C R Bentley ◽  
M D Sanders
Keyword(s):  
Optic Neuropathy ◽  
Visual Loss ◽  
Severe Visual Loss ◽  
Churg Strauss

Leber's Hereditary Optic Neuropathy as a Cause of Severe Visual Loss in Childhood

PEDIATRICS ◽  
1993 ◽  
Vol 91 (5) ◽  
pp. 988-989
Author(s):  
C. M. MOORMAN ◽  
J. S. ELSTON ◽  
P. MATTHEWS
Keyword(s):  
Optic Neuropathy ◽  
Visual Loss ◽  
Age Of Onset ◽  
Transmitted Disease ◽  
Point Mutations ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Severe Visual Loss ◽  
Sporadic Cases ◽  
Hereditary Optic Neuropathy

Leber's hereditary optic neuropathy (LHON) is a rare, maternally transmitted disease that most commonly causes acute or subacute visual loss in young men, typically between the ages of 17 and 24 years (although perhaps 14% of affected individuals are women), which may be associated with systemic disorders, eg, cardiac dysrhythmias and neurologic problems.1 Onset is usually asymmetric, but intervals between involvement of the two eyes are usually less than a few months. A definitive diagnosis rested on a family history, age of onset, and the characteristic circumpapillary microangiopathy of the optic disc in the acute phase. However, recent demonstration of point mutations of mitochondrial DNA in affected individuals means that confirmation of the diagnosis can now be obtained in atypical or sporadic cases.2

scholarly journals Metronidazole-Induced Irreversible Optic Neuropathy

2021 ◽  
pp. 392-395
Author(s):  
Pai-Huei Peng ◽  
Tzu-En Wu ◽  
Ting-Yu Lin
Keyword(s):  
Optic Neuropathy ◽  
Visual Loss ◽  
Rare Complication ◽  
Sudden Onset ◽  
Visual Recovery ◽  
Severe Visual Loss

Metronidazole-induced optic neuropathy is a rare complication. Most patients have excellent visual recovery. In this study, we report a patient who presented with a sudden onset of severe visual loss after a 1-week course of metronidazole. Myelitis developed simultaneously. The vision and the accompanying neurological deficiency of the patient did not improve even after metronidazole was discontinued immediately and various treatments were given.

Primary optic neuropathy in Behçet’s syndrome

2018 ◽  
Vol 25 (8) ◽  
pp. 1132-1140
Author(s):  
Qinglin Yang ◽  
Lin Sun ◽  
Qian Wang ◽  
Jiawei Wang ◽  
Chao Meng ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuropathy ◽  
Visual Loss ◽  
Case Reports ◽  
Cumulative Risk ◽  
Behçet’S Syndrome ◽  
Behçet's Syndrome ◽  
Severe Visual Loss ◽  
Behcet’S Syndrome ◽  
Behcet's Syndrome

Background: Primary optic neuropathy in Behçet’s syndrome (PONBS) is limited to a few case reports. Objective: To investigate the clinical features, magnetic resonance imaging (MRI) changes, and visual prognosis of PONBS. Methods: Sixty-one patients who presented with first onset of optic neuritis and fulfilled the International Criteria for Behçet’s Disease (ICBD) were evaluated. Results: The female-to-male ratio was 1.7:1. No patient had other central nervous system (CNS) disease. In 67 eyes with optic nerve abnormalities on MRI scan, perineural enhancement around the orbital optic nerve (46 eyes, 68.7%) was significantly more frequent than was increased signal in the optic nerve itself (31 eyes, 46.3%; p = 0.000), typically with sunflower-like appearance on coronal view (33 eyes, 71.7%). Two patients (3.6%) relapsed during follow-up (median 12 months). Kaplan–Meier survival analysis estimated the cumulative risk of severe visual loss (⩽0.1) at 24 months was 14.7% in females versus 62.5% in males (hazard ratio (HR), 0.16; 95% confidence interval, 0.05–0.54). Conclusion: PONBS frequently presents with isolated optic neuropathy in females. The sunflower-like sign might be a distinctive MRI feature. Short-term recurrence is very rare. Males have a higher cumulative risk of severe visual loss.

scholarly journals Visual loss from optic neuropathy in dermatomyositis

Rheumatology ◽  
2004 ◽  
Vol 43 (3) ◽  
pp. 391-393 ◽  
Author(s):  
R. Foroozan
Keyword(s):  
Optic Neuropathy ◽  
Visual Loss

scholarly journals Compressive Optic Neuropathy Caused by Orbital Non-Hodgkin's Lymphoma

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Mohammed M. Ziaei ◽  
Hadi Ziaei
Keyword(s):  
Optic Nerve ◽  
Paranasal Sinus ◽  
Optic Neuropathy ◽  
Hodgkin’S Lymphoma ◽  
Visual Loss ◽  
Hodgkin's Lymphoma ◽  
Compressive Optic Neuropathy ◽  
Acute Visual Loss ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Purpose. To present a unique case of Non-Hodgkin’s-Lymphoma- (NHL) associated compressive optic neuropathy.Method. An 89-year-old male presenting with acute unilateral visual loss and headache.Results. Patient was initially diagnosed with occult giant cell arteritis; however after visual acuity deteriorated despite normal inflammatory markers, an urgent MRI scan revealed an extensive paranasal sinus mass compressing the optic nerve.Conclusion. Paranasal sinus malignancies occasionally present to the ophthalmologist with signs of optic nerve compression and must be included in the differential diagnosis of acute visual loss.

scholarly journals MOG Antibody Positive Optic Perineuritis: an Observational Study in Han Chinese

2021 ◽  
Author(s):  
CHAO MENG ◽  
Jia-wei Wang ◽  
Lei Liu ◽  
Wen-jing Wei ◽  
Jian-hua Tao ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Visual Loss ◽  
Clinical Symptoms ◽  
Optic Chiasm ◽  
Han Chinese ◽  
Younger Patients ◽  
Brainstem Lesions ◽  
Severe Visual Loss ◽  
Mri Changes ◽  
Magnet Resonance

Abstract ObjectiveTo shed light on the clinical characteristics, magnet resonance imaging(MRI) changes, and prognosis of myelin oligodendrocyte glycoprotein antibody (MOG-IgG) positive OPN in Han Chinese.MethodsWe observed 39 MOG-IgG positive patients in our ward from January 1, 2017 , to December 31, 2019. Twenty patients met OPN inclusion criteria included contrast enhancement surrounding the optic nerve, and at least one of the following clinical symptoms: 1) reduction of visual acuity, 2) impairment of visual field, and 3) eye pain. Single course group(n=11) and recurrence group(n=9) were used for comparison. Outcome variables included Wingerchuk visual acuity classification.Results Of the 20 patients with MOG-IgG positive OPN, 12(60%) were women. Ten cases (50%) presented with bilateral and 17 eyes (56.67%) with severe visual loss (SVL,≤ 0.1). Twenty-one(70.00%) eyes showed edema of optic disc. Twenty-five eyes (83.3%) had longitudinally extensive perineural enhancement. At follow-up, 4 (13%) eyes still had SVL, while 26 (87%) eyes had no SVL, and of the 19 ON patients, 3 (9%) eyes still had SVL. Seven patients (35.00%) experienced at least a relapse(median interval 13.5 months ), and of the 19 ON cases, 4 (21%) patients experienced relapse. The relapse occurred more often in younger patients than the older (mean year: 38.00 vs. 45.54 years; P = 0.025). There were no optic chiasm and brainstem lesions.ConclusionsMOG-IgG positive OPN in Han Chinese often causes severe bilateral visual loss and longitudinally extensive perineural lesion. Younger patients are more likely to relapse. Optic chiasm and brainstem lesions were relatively rare.

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