scholarly journals Metronidazole-Induced Irreversible Optic Neuropathy

2021 ◽  
pp. 392-395
Author(s):  
Pai-Huei Peng ◽  
Tzu-En Wu ◽  
Ting-Yu Lin
Keyword(s):  
Optic Neuropathy ◽  
Visual Loss ◽  
Rare Complication ◽  
Sudden Onset ◽  
Visual Recovery ◽  
Severe Visual Loss

Metronidazole-induced optic neuropathy is a rare complication. Most patients have excellent visual recovery. In this study, we report a patient who presented with a sudden onset of severe visual loss after a 1-week course of metronidazole. Myelitis developed simultaneously. The vision and the accompanying neurological deficiency of the patient did not improve even after metronidazole was discontinued immediately and various treatments were given.

Leber's Hereditary Optic Neuropathy as a Cause of Severe Visual Loss in Childhood

PEDIATRICS ◽  
1993 ◽  
Vol 91 (5) ◽  
pp. 988-989
Author(s):  
C. M. MOORMAN ◽  
J. S. ELSTON ◽  
P. MATTHEWS
Keyword(s):  
Optic Neuropathy ◽  
Visual Loss ◽  
Age Of Onset ◽  
Transmitted Disease ◽  
Point Mutations ◽  
Leber’S Hereditary Optic Neuropathy ◽  
Leber's Hereditary Optic Neuropathy ◽  
Severe Visual Loss ◽  
Sporadic Cases ◽  
Hereditary Optic Neuropathy

Leber's hereditary optic neuropathy (LHON) is a rare, maternally transmitted disease that most commonly causes acute or subacute visual loss in young men, typically between the ages of 17 and 24 years (although perhaps 14% of affected individuals are women), which may be associated with systemic disorders, eg, cardiac dysrhythmias and neurologic problems.1 Onset is usually asymmetric, but intervals between involvement of the two eyes are usually less than a few months. A definitive diagnosis rested on a family history, age of onset, and the characteristic circumpapillary microangiopathy of the optic disc in the acute phase. However, recent demonstration of point mutations of mitochondrial DNA in affected individuals means that confirmation of the diagnosis can now be obtained in atypical or sporadic cases.2

scholarly journals Churg-Strauss vasculitis presenting with severe visual loss due to bilateral sequential optic neuropathy.

1993 ◽  
Vol 77 (2) ◽  
pp. 118-119 ◽  
Author(s):  
J F Acheson ◽  
O C Cockerell ◽  
C R Bentley ◽  
M D Sanders
Keyword(s):  
Optic Neuropathy ◽  
Visual Loss ◽  
Severe Visual Loss ◽  
Churg Strauss

Primary optic neuropathy in Behçet’s syndrome

2018 ◽  
Vol 25 (8) ◽  
pp. 1132-1140
Author(s):  
Qinglin Yang ◽  
Lin Sun ◽  
Qian Wang ◽  
Jiawei Wang ◽  
Chao Meng ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuropathy ◽  
Visual Loss ◽  
Case Reports ◽  
Cumulative Risk ◽  
Behçet’S Syndrome ◽  
Behçet's Syndrome ◽  
Severe Visual Loss ◽  
Behcet’S Syndrome ◽  
Behcet's Syndrome

Background: Primary optic neuropathy in Behçet’s syndrome (PONBS) is limited to a few case reports. Objective: To investigate the clinical features, magnetic resonance imaging (MRI) changes, and visual prognosis of PONBS. Methods: Sixty-one patients who presented with first onset of optic neuritis and fulfilled the International Criteria for Behçet’s Disease (ICBD) were evaluated. Results: The female-to-male ratio was 1.7:1. No patient had other central nervous system (CNS) disease. In 67 eyes with optic nerve abnormalities on MRI scan, perineural enhancement around the orbital optic nerve (46 eyes, 68.7%) was significantly more frequent than was increased signal in the optic nerve itself (31 eyes, 46.3%; p = 0.000), typically with sunflower-like appearance on coronal view (33 eyes, 71.7%). Two patients (3.6%) relapsed during follow-up (median 12 months). Kaplan–Meier survival analysis estimated the cumulative risk of severe visual loss (⩽0.1) at 24 months was 14.7% in females versus 62.5% in males (hazard ratio (HR), 0.16; 95% confidence interval, 0.05–0.54). Conclusion: PONBS frequently presents with isolated optic neuropathy in females. The sunflower-like sign might be a distinctive MRI feature. Short-term recurrence is very rare. Males have a higher cumulative risk of severe visual loss.

scholarly journals A Typical Case Presentation with Spontaneous Visual Recovery in Patient Diagnosed with Leber Hereditary Optic Neuropathy due to Rare Point Mutation in MT-ND4 Gene (m.11253T>C) and Literature Review

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 202
Author(s):  
Rasa Liutkeviciene ◽  
Agne Sidaraite ◽  
Lina Kuliaviene ◽  
Brigita Glebauskiene ◽  
Neringa Jurkute ◽  
...  
Keyword(s):  
Optic Neuropathy ◽  
Vision Loss ◽  
European Medicines Agency ◽  
Visual Recovery ◽  
Leber Hereditary Optic Neuropathy ◽  
Diagnostic Features ◽  
Mitochondrial Respiratory Chain Complex ◽  
Male Predominance ◽  
Mtdna Mutations ◽  
Hereditary Optic Neuropathy

Leber hereditary optic neuropathy (LHON) is one of the most common inherited mitochondrial optic neuropathies, caused by mitochondrial DNA (mtDNA) mutations. Three most common mutations, namely m.11778G>A, m.14484T>G and m.3460G>A, account for the majority of LHON cases. These mutations lead to mitochondrial respiratory chain complex I damage. Typically, LHON presents at the 15–35 years of age with male predominance. LHON is associated with severe, subacute, painless bilateral vision loss and account for one of the most common causes of legal blindness in young individuals. Spontaneous visual acuity recovery is rare and has been reported in patients harbouring m.14484T>C mutation. Up to date LHON treatment is limited. Idebenone has been approved by European Medicines Agency (EMA) to treat LHON. However better understanding of disease mechanisms and ongoing treatment trials are promising and brings hope for patients. In this article we report on a patient diagnosed with LHON harbouring rare m.11253T>C mutation in MT-ND4 gene, who experienced spontaneous visual recovery. In addition, we summarise clinical presentation, diagnostic features, and treatment.

scholarly journals Visual loss from optic neuropathy in dermatomyositis

Rheumatology ◽  
2004 ◽  
Vol 43 (3) ◽  
pp. 391-393 ◽  
Author(s):  
R. Foroozan
Keyword(s):  
Optic Neuropathy ◽  
Visual Loss

scholarly journals A dangerous pleural effusion

2010 ◽  
Vol 92 (5) ◽  
pp. e53-e54 ◽  
Author(s):  
Somprakas Basu ◽  
Shilpi Bhadani ◽  
Vijay K Shukla
Keyword(s):  
Rare Complication ◽  
Sudden Onset ◽  
Biliary Surgery ◽  
Biliary Leak ◽  
X Ray ◽  
Delay In Diagnosis ◽  
Aged Woman ◽  
Middle Aged Woman ◽  
Life Threatening ◽  
Chest X Ray

Bilothorax is a rare complication of biliary peritonitis and, if not treated promptly, can be life-threatening. We report a case of a middle-aged woman who had undergone a bilio-enteric bypass and subsequently a biliary leak developed, which finally led to intra-abdominal biliary collection and spontaneous bilothorax. The clinical course was rapid and mimicked venous thromboembolism, myocardial infarction and pulmonary oedema, which led to a delay in diagnosis and management and finally death. We high-light the fact that bilothorax, although a rare complication of biliary surgery, should always be considered as a probable cause of massive effusion and sudden-onset respiratory and cardiovascular collapse in the postoperative period. A chest X-ray and a diagnostic pleural tap can confirm the diagnosis. Once detected, an aggressive management should be instituted to prevent organ failure and death.

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