scholarly journals Compressive Optic Neuropathy Caused by Orbital Non-Hodgkin's Lymphoma

2012 ◽  
Vol 2012 ◽  
pp. 1-3
Author(s):  
Mohammed M. Ziaei ◽  
Hadi Ziaei
Keyword(s):  
Optic Nerve ◽  
Paranasal Sinus ◽  
Optic Neuropathy ◽  
Hodgkin’S Lymphoma ◽  
Visual Loss ◽  
Hodgkin's Lymphoma ◽  
Compressive Optic Neuropathy ◽  
Acute Visual Loss ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Purpose. To present a unique case of Non-Hodgkin’s-Lymphoma- (NHL) associated compressive optic neuropathy.Method. An 89-year-old male presenting with acute unilateral visual loss and headache.Results. Patient was initially diagnosed with occult giant cell arteritis; however after visual acuity deteriorated despite normal inflammatory markers, an urgent MRI scan revealed an extensive paranasal sinus mass compressing the optic nerve.Conclusion. Paranasal sinus malignancies occasionally present to the ophthalmologist with signs of optic nerve compression and must be included in the differential diagnosis of acute visual loss.

SYSTEMIC NON-HODGKIN’S LYMPHOMA WITH OPTIC NERVE INFILTRATION IN A PATIENT WITH AIDS

Retina ◽  
2002 ◽  
Vol 22 (1) ◽  
pp. 75-79 ◽  
Author(s):  
LILLIAN C. LEE ◽  
EDWARD L. HOWES ◽  
ROBERT B. BHISITKUL
Keyword(s):  
Optic Nerve ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Acquired C1-esterase Deficiency and Optic Neuropathy in Non-Hodgkin's Lymphoma

2006 ◽  
Vol 18 (6) ◽  
pp. 507-508 ◽  
Author(s):  
A. Al-Futaisi ◽  
A. Ganesh ◽  
A. Almahrezi ◽  
M. Farooqui
Keyword(s):  
Optic Neuropathy ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Unilateral optic neuropathy in non-Hodgkin's lymphoma

Neurology ◽  
1987 ◽  
Vol 37 (9) ◽  
pp. 1563-1563 ◽  
Author(s):  
D. J. Lanska ◽  
M. J. Lanska ◽  
R. L. Tomsak
Keyword(s):  
Optic Neuropathy ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

Antiphospholipid Antibodies: Prevalence, Clinical Significance and Correlation to Cytokine Levels in Acute Myeloid Leukemia and Non-Hodgkin’s Lymphoma

1993 ◽  
Vol 70 (04) ◽  
pp. 568-572 ◽  
Author(s):  
Roberto Stasi ◽  
Elisa Stipa ◽  
Mario Masi ◽  
Felicia Oliva ◽  
Alessandro Sciarra ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Clinical Significance ◽  
Antiphospholipid Antibodies ◽  
Myeloid Leukemia ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Tnf Alpha ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Acute Myeloid

SummaryThis study was designed to explore the prevalence and clinical significance of elevated antiphospholipid antibodies (APA) titres in patients affected by acute myeloid leukemia (AML) and highgrade non-Hodgkin’s lymphoma (NHL). We also analyzed possible correlations with circulating levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and the soluble form of the receptor for interleukin-2 (sIL-2r). Nineteen patients with de novo AML and 14 patients with newly-diagnosed NHL were investigated. Tests for APA included the measurement of anticardiolipin antibodies (ACA) with a solid-phase immunoassay, and the detection of the lupus-like anticoagulant (LA) activity. Five patients with AML (26.3%) and 5 patients with NHL (35.7%) presented elevated APA at diagnosis, as compared to 3 of 174 persons of the control group (p <0.0001). APA titres became normal in all patients responding to treatment, whereas nonresponders retained elevated levels. In addition, 6 patients (4 with AML and 2 with NHL), who had normal APA at diagnosis and were either refractory to treatment or in relapse, subsequently developed LA and/or ACA positivity. At presentation, the mean levels of IgG- and IgM-ACA in patients were not significantly different from Controls, and concordance between ACA and LA results reached just 30%. With regard to the clinical course, we were not able to detect any statistically significant difference between patients with normal and elevated APA. Pretreatment concentrations of IL-6 and TNF-alpha in AML, and sIL-2r in NHL were found significantly elevated compared to Controls (p = 0.003, p = 0.009 and p = 0.024 respectively). In addition, the levels of these cytokines correlated with IgG-ACA at the different times of laboratory investigations. These results demonstrate that APA may have a role as markers of disease activity and progression in some haematological malignancies.

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