Synthesis of some 3-substituted 4(3H)-quinazolinone and 4(3H)-quinazolinethione derivatives and related fused biheterocyclic ring systems

1988 ◽  
Vol 53 (2) ◽  
pp. 329-335 ◽  
Author(s):  
Mohamed Farghali Abdel-Megeed ◽  
Abderrahman Teniou
Keyword(s):  
Hydrazine Hydrate ◽  
Mass Spectroscopy ◽  
Biological Activities ◽  
Phenyl Isocyanate ◽  
Phenyl Isothiocyanate ◽  
Ring Systems ◽  
H Nmr

The reactions of 2-phenyl-4(3H)-quinazoline, 2-phenyl-3-amino-4(3H)-quinazolinone, and corresponding thiones with phenyl isocyanate or phenyl isothiocyanate were investigated. The resulting urea and thiourea quinazolinone or quinazolinethione derivatives reacted with hydrazine hydrate, phenylhydrazine, and urea or thiourea to form fused biheterocyclic ring systems with potential biological activities. The products were identified by IR, 1H NMR, and mass spectroscopy.

scholarly journals Synthesis Antimicrobial and Anticancer Evaluation of 1-Aryl-5-(o-methoxyphenyl)-2-S-benzyl Isothiobiurets

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Mohammed M. Ansari ◽  
Shirish P. Deshmukh ◽  
Rizwan Khan ◽  
Mohammed Musaddiq
Keyword(s):  
Biological Activities ◽  
Phenyl Isocyanate ◽  
Spectral Studies ◽  
Mass Spectral ◽  
H Nmr

A series of S-benzyl aryl thiourea were condensed with o-Methoxy phenyl isocyanate to yield respective isothiobiuret derivatives. The newly synthesized compounds were characterized by 1H-NMR, IR, and Mass Spectral studies and tested for biological activities.

Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents

2020 ◽  
Vol 26 (1) ◽  
pp. 6-13 ◽  
Author(s):  
Ulviye Acar Çevik ◽  
Derya Osmaniye ◽  
Serkan Levent ◽  
Begüm Nurpelin Sağlik ◽  
Betül Kaya Çavuşoğlu ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Activities ◽  
Cancer Cell Line ◽  
Chemotherapeutic Agents ◽  
Anticancer Activities ◽  
Normal Tissues ◽  
H Nmr ◽  
Wide Range ◽  
Thiadiazole Derivatives ◽  
Low Efficiency

AbstractCancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are major problems in chemotherapy. Nowadays the aim of many medical research projects is to discover new safer and more effective anticancer agents. 1,3,4-Thiadiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities, including anticancer activities. The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds as chemotherapeutic agents. The structures of the obtained compounds were elucidated using 1H-NMR, 13C-NMR and mass spectrometry. Although the thiadiazole derivatives did not prove to be significantly cytotoxic to the tumour tissue cultures, compound 4i showed activity against the C6 rat brain cancer cell line (IC50 0.097 mM) at the tested concentrations.

scholarly journals Synthesis, Characterization, and Electrochemical Behaviour of Cobalt(II) and Nickel(II) Complexes with N2O2 Chelating Ligand 4,4′-(Biphenyl-4,4′-diyldinitrilo)dipentan-2-one

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Lakhdar Sibous ◽  
Embarek Bentouhami ◽  
Mustayeen Ahmed Khan
Keyword(s):  
Schiff Base ◽  
Mass Spectroscopy ◽  
Elemental Analysis ◽  
Electrochemical Behaviour ◽  
Absolute Ethanol ◽  
Molar Ratio ◽  
H Nmr ◽  
Chelating Ligand ◽  
Metal Ligand

4,4′-Diaminobiphenyl reacts with 2,4-pentanedione in absolute ethanol in a molar ratio 1 : 2 to form mainly the product of [1 + 2] condensation, 4,4′-(biphenyl-4,4′-diyldinitrilo)dipentan-2-one (H2L). The Schiff base was used as tetradentate chelating ligand to coordinate CoII and NiII chlorides leading to complexes where the ratio of metal ligand was found to be 2 : 1 or 2 : 2. All the synthesized products were characterized by elemental analysis, infrared, electronic, and mass spectroscopy, 1H NMR, and DSC. The electrochemical behaviour of the ligand and its complexes in DMF is also investigated.

Synthesis, Characterization and Complexation Studies with K + and Ca2+ Cations of trans-1.2-Cyclohexanedioxydiacetamides

1988 ◽  
Vol 43 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Whei Oh Lin ◽  
Maria C. B. V. de Souza ◽  
Helmut G. Alt
Keyword(s):  
Nmr Spectroscopy ◽  
Mass Spectroscopy ◽  
H Nmr ◽  
Coordination Sites ◽  
Complexation Studies ◽  
Ir And Nmr Spectroscopy ◽  
Elemental Analyses ◽  
C Nmr

The synthesis of trans-1.2-cyclohexanedioxydiacetamides starting with trans-1.2-cyclohexane-diol is described. Eleven of these compounds are characterized by IR, 1H NMR, 13C NMR and mass spectroscopy as well as elemental analyses. Most of these compounds are suitable ionophors for the cations K+ and Ca2+. The coordination sites of these ligands in the 1:2 complexes were determined by IR and NMR spectroscopy

1 H NMR and Raman spectroscopy of oils and extracts obtained from organic and conventional goji berries: yield, fatty acids, carotenoids and biological activities

2018 ◽  
Vol 54 (1) ◽  
pp. 282-290 ◽  
Author(s):  
Alessandra Cristina Pedro ◽  
Fabiane Bach ◽  
Ana Paula Stafussa ◽  
Leociley Rocha Alencar Menezes ◽  
Andersson Barison ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Raman Spectroscopy ◽  
Biological Activities ◽  
H Nmr ◽  
Goji Berries

scholarly journals Synthesis, Characterization, and Agricultural Biological Activities of 5-Fluoro-2-hydroxy Butyrophenone

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Fengli Xin ◽  
Chunhua Du ◽  
Gongjia Lan ◽  
Zhuanping Wu
Keyword(s):  
Lactuca Sativa ◽  
Biological Activities ◽  
Raw Material ◽  
Synthetic Approach ◽  
Target Compound ◽  
Echinochloa Crusgalli ◽  
Agricultural Plant ◽  
H Nmr ◽  
Valsa Mali ◽  
C Nmr

A novel synthetic approach towards 5-fluoro-2-hydroxy butyrophenone is reported. Using 4-fluorophenol as a raw material, the processes of etherification protection, Friedel-Crafts acylation and demethylation provide the target compound under mild conditions. The structure was characterized by the melting point and IR, MS,1H-NMR, and13C-NMR spectroscopy. The bioassay results indicate that the target compound exhibits potent antifungal activities againstValsa mali,Coniella dipodiella, and other agricultural plant fungi. The target compound also shows potent herbicidal activities forLactuca sativa, a dicotyledon, andEchinochloa crus-galli, a monocotyledon. The toxicity regression C50values of the compound againstValsa mali,Coniothyrium diplodiella,Lactuca sativaseedling, andEchinochloa crusgalliseedling were calculated by SPSS. The Hormesis effect for roots ofEchinochloa crusgalliwas confirmed.

Novel lariat calix[4]-1,3-aza-crowns with two branched chains — The excellent phase transfer catalysts for nucleophilic substitution reaction

2010 ◽  
Vol 88 (7) ◽  
pp. 622-627 ◽  
Author(s):  
Fafu Yang ◽  
Yanhua Wang ◽  
Hongyu Guo ◽  
Jianwei Xie ◽  
Zhiqiang Liu
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Phase Transfer ◽  
Hard Metal ◽  
Nucleophilic Substitution Reaction ◽  
Phenyl Isothiocyanate ◽  
Phase Transfer Catalysts ◽  
H Nmr ◽  
Branched Chains ◽  
New Compounds

By reacting calix[4]-1,3-diethoxylaminoethyl derivative (2) with phenyl isothiocyanate, novel dendritic calix[4]arene derivative (3) with two different branched chains was synthesized in a yield of 78%. By reacting compound 2 with 1,6-diisocyanatohexane or N,N′-bis(2-chloracetamide)ethylene in a “1 + 1” intermolecular addition mode, novel lariat calix[4]-1,3-aza-crowns (4 and 5, respectively) with two branched ethoxyl chains were prepared in reasonable yields. The composition, structures, and conformations of all new compounds were confirmed by elemental analyses, IR, ESI-MS, 1H NMR, and so forth. The liquid–liquid extraction experiments showed that all new hosts possessed good extraction abilities towards soft and hard metal cations. The liquid membrane transport experiments suggested that they had good transport abilities for K+ and Ag+. The experiments of phase transfer catalysis indicated that they possessed excellent catalytic properties of aromatic nucleophilic substitution reaction and benzyl nucleophilic substitution. The optimum yields of products in catalytic reaction were as high as approximately 100%.

Synthesen und Reaktionen von schwefelkoordinierten Ruthenium-Komplexen [1]/Syntheses and Reactions of Sulfur Coordinated Ruthenium Complexes [1]

1982 ◽  
Vol 37 (8) ◽  
pp. 1026-1033 ◽  
Author(s):  
Dieter Sellmann ◽  
Elmar Böhlen
Keyword(s):  
Mass Spectroscopy ◽  
Ruthenium Complexes ◽  
H Nmr ◽  
Elemental Analyses

Abstract The syntheses and reactions of sulfur coordinated ruthenium centers with CO, PR3, (R = Me, Ø), N2H4 and N2 are investigated. Reaction of [Ru(CO)3(THF)Cl2] with lithium-o-methylthiobenzenethiolate yields cis-[Ru(CO)2(CH3S-C6H4-S)2], with Li2-o-benzenedithiolate the cis-[Ru(CO)2(C6H4S2)2]2--ion is obtained, which can be isolated either as the NMe4 salt or reacted further with 1,2-C2H4Br2 to give cis-[Ru(CO)2dttd], (dttd2-= 2,3,8,9-Dibenzo-1,4,7,10-tetrathiadecane2-). In all three complexes the CO ligands are relatively inert to substitution; refluxing of [Ru(CO)2(C6H4S2)2]2- in EtOH in the presence of excess PMe3, however, and subsequent alkylation with 1,2-C2H4Br2 yields [Ru(CO)PMe3(dttd)]. [Ru(PMe3)2dttd] is obtained from [Ru(PMe3)4Cl2] and Li2-dttd, the synthesis of which is also described. In [Ru(PMe3)2(dttd)] the PMe3 ligands are inert, but in [Ru(PØ3)2(dttd)] one PØ3 ligand is easily substituted by CO or N2H4 yielding [Ru(CO)(PØ3)dttd] or [Ru(N2H4)(PØ3)dttd] respectively; [Ru(PØ3)2(dttd)] is obtained from [RU(PØ3)3Cl2] and H2-dttd. The complexes are characterized by elemental analyses, IR, 1H NMR and mass spectroscopy.

scholarly journals Übergangsmetall-substituierte VB Elementsysteme, 7.

1975 ◽  
Vol 30 (3-4) ◽  
pp. 229-234 ◽  
Author(s):  
Wolfgang Malisch ◽  
Peter Panster
Keyword(s):  
Transition Metal ◽  
Mass Spectroscopy ◽  
Bond Cleavage ◽  
Metal Carbonyl ◽  
Metal Carbonyls ◽  
H Nmr ◽  
Complex Metal ◽  
Stable Species ◽  
New Compounds

The reaction of SbBr3 with the complex metal carbonyl anions [π-C5H6(CO)3M]Na (M = Mo, W) leads to the formation of transition metal antimony bromides π-C5H5(CO)3M-Sb̅-Br2, which can be further metallated, yielding the stable species [XXX]All bromine substituted transition metal stibines prove to be excellent coordinating ligands and can easily be introduced into activated metal carbonyls. The interaction of π-C5H5(CO)3M-Sb̅Br2, with bromine results in a quantitative Sb-M bond cleavage, presumably via primary formation of pentavalent intermediates. All new compounds are fully characterized by means of IR, 1H NMR and mass spectroscopy.

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