scholarly journals Ketolide Treatment of Haemophilus influenzae Experimental Pneumonia

1999 ◽  
Vol 43 (3) ◽  
pp. 708-710 ◽  
Author(s):  
Kerryl E. Piper ◽  
Mark S. Rouse ◽  
James M. Steckelberg ◽  
Walter R. Wilson ◽  
Robin Patel
Keyword(s):  
Haemophilus Influenzae ◽  
Murine Model ◽  
Beta Lactamase ◽  
Experimental Pneumonia ◽  
Pulmonary Clearance ◽  
Erythromycin A

The MICs of HMR 3004 and HMR 3647 at which 90% of beta-lactamase-producing Haemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase-producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.

Establishment of Nontypeable Haemophilus influenzae airway infection murine model

2020 ◽  
Author(s):  
Genki Kimura ◽  
Yuki Nishimoto ◽  
Takahiro Nakaoki ◽  
Kazuhiro Ito ◽  
Yasuo Kizawa
Keyword(s):  
Haemophilus Influenzae ◽  
Murine Model ◽  
Nontypeable Haemophilus Influenzae ◽  
Airway Infection

scholarly journals In Vivo Efficacy of Telithromycin (HMR3647) againstStreptococcus pneumoniae and Haemophilus influenzae

2001 ◽  
Vol 45 (11) ◽  
pp. 3250-3252 ◽  
Author(s):  
Hiroki Okamoto ◽  
Shuichi Miyazaki ◽  
Kazuhiro Tateda ◽  
Yoshikazu Ishii ◽  
Keizo Yamaguchi
Keyword(s):  
Streptococcus Pneumoniae ◽  
Respiratory Tract ◽  
Haemophilus Influenzae ◽  
Respiratory Tract Infections ◽  
Penicillin G ◽  
In Vivo Efficacy ◽  
Erythromycin A ◽  
Tract Infections

ABSTRACT The in vivo activity of telithromycin against erythromycin A- and penicillin G-resistant Streptococcus pneumoniae was superior to that of azithromycin, clarithromycin, cefdinir, and levofloxacin. In respiratory tract infections caused by erythromycin A-susceptible S. pneumoniae or Haemophilus influenzae in mice, telithromycin was more effective than clarithromycin and comparable to azithromycin.

scholarly journals In Vitro Activities of Novel 2-Fluoro-Naphthyridine-Containing Ketolides

2005 ◽  
Vol 49 (1) ◽  
pp. 309-315 ◽  
Author(s):  
Darren Abbanat ◽  
Glenda Webb ◽  
Barbara Foleno ◽  
Y. Li ◽  
Mark Macielag ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Streptococcus Pneumoniae ◽  
Respiratory Tract ◽  
Haemophilus Influenzae ◽  
Moraxella Catarrhalis ◽  
Bacterial Strains ◽  
Erythromycin A ◽  
Time Kill ◽  
Vitro Protein

ABSTRACT In vitro activities of erythromycin A, telithromycin, and two investigational ketolides, JNJ-17155437 and JNJ-17155528, were evaluated against clinical bacterial strains, including selected common respiratory tract pathogens. Against 46 macrolide-susceptible and -resistant Streptococcus pneumoniae strains, the MIC90 (MIC at which 90% of the isolates tested were inhibited) of the investigational ketolides was 0.25 μg/ml, twofold lower than that of telithromycin and at least 64-fold lower than that of erythromycin A. Against erm(B)-containing pneumococci, the MIC90 of all the ketolides was 0.06 μg/ml. The MIC90 of the investigational ketolides against mef(A)-containing pneumococci or pneumococci with both mef(A) and erm(B) was 0.25 μg/ml, two-and fourfold lower, respectively, than that of telithromycin. In contrast, the MICs of the investigational ketolides against macrolide-resistant S. pneumoniae strains with ribosomal mutations were similar to or, in some cases, as much as eightfold higher than those of telithromycin. Against Haemophilus influenzae, MICs of all the ketolides were ≤2 μg/ml. Against three Moraxella catarrhalis isolates, the MIC of the ketolides was 0.25 μg/ml. The ketolides inhibited in vitro protein synthesis, with 50% inhibitory concentrations ranging from 0.23 to 0.27 μM. In time-kill studies against macrolide-susceptible and erm- or mef-containing pneumococci, the ketolides were bacteriostatic to slowly bactericidal, with 24-h log10 decreases ranging from 2.0 to 4.1 CFU. Intervals of postantibiotic effects for the ketolides against macrolide-susceptible and -resistant S. pneumoniae were 3.0 to 8.1 h.

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