scholarly journals Isolation of an ampicillin-resistant, non-beta-lactamase-producing strain of Haemophilus influenzae.

1980 ◽  
Vol 17 (1) ◽  
pp. 80-83 ◽  
Author(s):  
S M Markowitz
Keyword(s):  
Haemophilus Influenzae ◽  
Beta Lactamase

scholarly journals Ketolide Treatment of Haemophilus influenzae Experimental Pneumonia

1999 ◽  
Vol 43 (3) ◽  
pp. 708-710 ◽  
Author(s):  
Kerryl E. Piper ◽  
Mark S. Rouse ◽  
James M. Steckelberg ◽  
Walter R. Wilson ◽  
Robin Patel
Keyword(s):  
Haemophilus Influenzae ◽  
Murine Model ◽  
Beta Lactamase ◽  
Experimental Pneumonia ◽  
Pulmonary Clearance ◽  
Erythromycin A

The MICs of HMR 3004 and HMR 3647 at which 90% of beta-lactamase-producing Haemophilus influenzae isolates were inhibited were 4 and 2 μg/ml, respectively. Both HMR 3004 and HMR 3647 were active against beta-lactamase-producing H. influenzae in a murine model of experimental pneumonia. As assessed by pulmonary clearance of H. influenzae, HMR 3004 was more effective (P < 0.05) than was azithromycin, ciprofloxacin, clarithromycin, erythromycin A, pristinamycin, or HMR 3647 in this model.

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