scholarly journals Salmonella Genomic Island 1 (SGI1), Variant SGI1-I, and New Variant SGI1-O in Proteus mirabilis Clinical and Food Isolates from China

2007 ◽  
Vol 52 (1) ◽  
pp. 340-344 ◽  
Author(s):  
David A. Boyd ◽  
Xiaolu Shi ◽  
Qing-hua Hu ◽  
Lai King Ng ◽  
Benoit Doublet ◽  
...  
Keyword(s):  
Proteus Mirabilis ◽  
Genomic Island ◽  
New Variant

ABSTRACT Salmonella genomic island 1 (SGI1) and variants (SGI1-I and the new variant SGI1-O) were mapped in five strains of Proteus mirabilis isolated from humans and food in China. Sequencing showed that SGI1 and variants were integrated at the 3′ end of the chromosomal thdF gene as previously described for Salmonella strains.

scholarly journals New variant Salmonella genomic island 1-U in Proteus mirabilis clinical and food isolates from South China

2011 ◽  
Vol 66 (5) ◽  
pp. 1178-1179 ◽  
Author(s):  
Shuilian Bi ◽  
He Yan ◽  
Miaorui Chen ◽  
Zhigang Zhang ◽  
Lei Shi ◽  
...  
Keyword(s):  
South China ◽  
Proteus Mirabilis ◽  
Genomic Island ◽  
New Variant

AsaGEI2d: a new variant of a genomic island identified in a group of Aeromonas salmonicida subsp. salmonicida isolated from France, which bears the pAsa7 plasmid

2021 ◽  
Author(s):  
Antony T Vincent ◽  
Laurent Intertaglia ◽  
Victor Loyer ◽  
Valérie E Paquet ◽  
Émilie Adouane ◽  
...  
Keyword(s):  
Genomic Island ◽  
Insertion Site ◽  
Aeromonas Salmonicida ◽  
Genomic Islands ◽  
The Other ◽  
Fish Pathogen ◽  
Integrase Gene ◽  
New Variant ◽  
Cat Gene ◽  
Unique Genes

Abstract Genomic islands (Aeromonas salmonicida genomic islands, AsaGEIs) are found worldwide in many isolates of Aeromonas salmonicida subsp. salmonicida, a fish pathogen. To date, five variants of AsaGEI (1a, 1b, 2a, 2b and 2c) have been described. Here, we investigate a sixth AsaGEI, which was identified in France between 2016 and 2019 in 20 A. salmonicida subsp. salmonicida isolates recovered from sick salmon all at the same location. This new AsaGEI shares the same insertion site in the chromosome as the other AsaGEI2s as they all have a homologous integrase gene. This new AsaGEI was thus named AsaGEI2d, and has 5 unique genes compared to the other AsaGEIs. The isolates carrying AsaGEI2d also bear the plasmid pAsa7, which was initially found in an isolate from Switzerland. This plasmid provides resistance to chloramphenicol thanks to a cat gene. This study reveals more about the diversity of the AsaGEIs.

scholarly journals Nosocomial Outbreak of Carbapenemase-Producing Proteus mirabilis With Two Novel Salmonella Genomic Island 1 Variants Carrying Different blaNDM–1 Gene Copies in China

2022 ◽  
Vol 12 ◽  
Author(s):  
Lang Yang ◽  
Hong He ◽  
Qichao Chen ◽  
Kaiying Wang ◽  
Yanfeng Lin ◽  
...  
Keyword(s):  
Proteus Mirabilis ◽  
Copy Number ◽  
Genomic Island ◽  
Gene Copy Number ◽  
Carbapenem Resistance ◽  
Multidrug Resistant ◽  
Gene Copy ◽  
Nosocomial Outbreak ◽  
Gene Copy Number Variation ◽  
Gene Copies

NDM-1-producing multidrug-resistant Proteus mirabilis brings formidable clinical challenges. We report a nosocomial outbreak of carbapenem-resistant P. mirabilis in China. Six P. mirabilis strains collected in the same ward showed close phylogenetic relatedness, indicating clonal expansion. Illumina and MinION sequencing revealed that three isolates harbored a novel Salmonella genomic island 1 carrying a blaNDM–1 gene (SGI1-1NDM), while three other isolates showed elevated carbapenem resistance and carried a similar SGI1 but with two blaNDM–1 gene copies (SGI1-2NDM). Four new single nucleotide mutations were present in the genomes of the two-blaNDM–1-harboring isolates, indicating later emergence of the SGI1-2NDM structure. Passage experiments indicated that both SGI variants were stably persistent in this clone without blaNDM–1 copy number changes. This study characterizes two novel blaNDM–1-harboring SGI1 variants in P. mirabilis and provides a new insight into resistance gene copy number variation in bacteria.

scholarly journals AsaGEI2b: a new variant of a genomic island identified in theAeromonas salmonicidasubsp.salmonicidaJF3224 strain isolated from a wild fish in Switzerland

2015 ◽  
Vol 362 (13) ◽  
pp. fnv093 ◽  
Author(s):  
Jean-Guillaume Emond-Rheault ◽  
Antony T. Vincent ◽  
Mélanie V. Trudel ◽  
Joachim Frey ◽  
Michel Frenette ◽  
...  
Keyword(s):  
Genomic Island ◽  
Wild Fish ◽  
New Variant

scholarly journals Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z

2015 ◽  
Vol 59 (10) ◽  
pp. 6601-6604 ◽  
Author(s):  
Shangshang Qin ◽  
Hui Qi ◽  
Qijing Zhang ◽  
Di Zhao ◽  
Zhen-Zhen Liu ◽  
...  
Keyword(s):  
Clinical Isolate ◽  
Molecular Analysis ◽  
Proteus Mirabilis ◽  
Genomic Island ◽  
Bacterial Species ◽  
Clinical Treatment ◽  
Drug Resistant ◽  
Content Type ◽  
Extensively Drug Resistant

ABSTRACTAcquisition ofblaNDM-1in bacterial species, such asProteus mirabilisthat is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate ofP. mirabilis(PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novelSalmonellagenomic island 1 variant on chromosome.

scholarly journals Potential integration sites of the Salmonella genomic island 1 in Proteus mirabilis and other bacteria

2007 ◽  
Vol 59 (4) ◽  
pp. 801-803 ◽  
Author(s):  
Benoît Doublet ◽  
George R. Golding ◽  
Michael R. Mulvey ◽  
Axel Cloeckaert
Keyword(s):  
Proteus Mirabilis ◽  
Genomic Island ◽  
Integration Sites ◽  
Potential Integration
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