scholarly journals Proteus mirabilis clinical isolate harbouring a new variant of Salmonella genomic island 1 containing the multiple antibiotic resistance region

2006 ◽  
Vol 59 (2) ◽  
pp. 184-190 ◽  
Author(s):  
A. M. Ahmed ◽  
A. I. A. Hussein ◽  
T. Shimamoto
Keyword(s):  
Antibiotic Resistance ◽  
Clinical Isolate ◽  
Proteus Mirabilis ◽  
Genomic Island ◽  
Multiple Antibiotic Resistance ◽  
New Variant

scholarly journals Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z

2015 ◽  
Vol 59 (10) ◽  
pp. 6601-6604 ◽  
Author(s):  
Shangshang Qin ◽  
Hui Qi ◽  
Qijing Zhang ◽  
Di Zhao ◽  
Zhen-Zhen Liu ◽  
...  
Keyword(s):  
Clinical Isolate ◽  
Molecular Analysis ◽  
Proteus Mirabilis ◽  
Genomic Island ◽  
Bacterial Species ◽  
Clinical Treatment ◽  
Drug Resistant ◽  
Content Type ◽  
Extensively Drug Resistant

ABSTRACTAcquisition ofblaNDM-1in bacterial species, such asProteus mirabilisthat is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate ofP. mirabilis(PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novelSalmonellagenomic island 1 variant on chromosome.

scholarly journals Salmonella Genomic Island 1 (SGI1), Variant SGI1-I, and New Variant SGI1-O in Proteus mirabilis Clinical and Food Isolates from China

2007 ◽  
Vol 52 (1) ◽  
pp. 340-344 ◽  
Author(s):  
David A. Boyd ◽  
Xiaolu Shi ◽  
Qing-hua Hu ◽  
Lai King Ng ◽  
Benoit Doublet ◽  
...  
Keyword(s):  
Proteus Mirabilis ◽  
Genomic Island ◽  
New Variant

ABSTRACT Salmonella genomic island 1 (SGI1) and variants (SGI1-I and the new variant SGI1-O) were mapped in five strains of Proteus mirabilis isolated from humans and food in China. Sequencing showed that SGI1 and variants were integrated at the 3′ end of the chromosomal thdF gene as previously described for Salmonella strains.

scholarly journals New variant of TEM-10 beta-lactamase gene produced by a clinical isolate of proteus mirabilis

1995 ◽  
Vol 39 (5) ◽  
pp. 1199-1200 ◽  
Author(s):  
T. Palzkill ◽  
K. S. Thomson ◽  
C. C. Sanders ◽  
E. S. Moland ◽  
W. Huang ◽  
...  
Keyword(s):  
Clinical Isolate ◽  
Proteus Mirabilis ◽  
Beta Lactamase ◽  
New Variant ◽  
Lactamase Gene

scholarly journals Variant Salmonella Genomic Island 1 Antibiotic Resistance Gene Cluster Containing a Novel 3′-N-Aminoglycoside Acetyltransferase Gene Cassette, aac(3)-Id, in Salmonella enterica Serovar Newport

2004 ◽  
Vol 48 (10) ◽  
pp. 3806-3812 ◽  
Author(s):  
Benoît Doublet ◽  
François-Xavier Weill ◽  
Laetitia Fabre ◽  
Elisabeth Chaslus-Dancla ◽  
Axel Cloeckaert
Keyword(s):  
Antibiotic Resistance ◽  
Gene Cluster ◽  
Resistance Gene ◽  
Salmonella Enterica ◽  
Genomic Island ◽  
Antibiotic Resistance Gene ◽  
Gene Cassette ◽  
Multidrug Resistant ◽  
Resistance Gene Cluster ◽  
New Variant

ABSTRACT Salmonella genomic island 1 (SGI1) harbors an antibiotic resistance gene cluster and was previously identified in the multidrug-resistant Salmonella enterica serovars Typhimurium DT104, Agona, Paratyphi B, and Albany. This antibiotic resistance gene cluster is a complex class 1 integron and most often confers resistance to ampicillin (Ap), chloramphenicol (Cm)/florfenicol (Ff), streptomycin (Sm)/spectinomycin (Sp), sulfonamides (Su), and tetracycline (Tc) (ApCmFfSmSpSuTc profile). Recently, variant SGI1 antibiotic resistance gene clusters conferring different antibiotic resistance profiles have been identified in several S. enterica serovars and were classified as SGI1-A to -G. We identified a new variant SGI1 antibiotic resistance gene cluster in two multidrug-resistant S. enterica serovar Newport strains isolated from humans in France. In these strains, the Sm/Sp resistance gene cassette aadA2 inserted at the first attI1 site was replaced by two other aminoglycoside resistance gene cassettes. The first one contains a new resistance gene encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase that confers resistance to gentamicin (Gm) and sisomicin (Sc). This gene has been named aac(3)-Id. The second one harbors the Sm/Sp resistance gene aadA7. This gene cassette replacement in the SGI1 complex integron of serovar Newport strains constitutes a new variant SGI1 antibiotic resistance gene cluster named SGI1-H. The occurrence of SGI1 in different S. enterica serovars, now including serovar Newport, strengthens the hypothesis of horizontal transfer of SGI1.

scholarly journals European clinical isolate of Proteus mirabilis harbouring the Salmonella genomic island 1 variant SGI1-O

2010 ◽  
Vol 65 (10) ◽  
pp. 2260-2262 ◽  
Author(s):  
Benoît Doublet ◽  
Laurent Poirel ◽  
Karine Praud ◽  
Patrice Nordmann ◽  
Axel Cloeckaert
Keyword(s):  
Clinical Isolate ◽  
Proteus Mirabilis ◽  
Genomic Island

scholarly journals Multiple-Antibiotic Resistance in Salmonella enterica Serotype Paratyphi B Isolates Collected in France between 2000 and 2003 Is Due Mainly to Strains Harboring Salmonella Genomic Islands 1, 1-B, and 1-C

2005 ◽  
Vol 49 (7) ◽  
pp. 2793-2801 ◽  
Author(s):  
François-Xavier Weill ◽  
Laëtitia Fabre ◽  
Bernadette Grandry ◽  
Patrick A. D. Grimont ◽  
Isabelle Casin
Keyword(s):  
Antibiotic Resistance ◽  
Salmonella Enterica ◽  
Genomic Island ◽  
Multidrug Resistant ◽  
Genomic Islands ◽  
Multiple Antibiotic Resistance ◽  
National Reference ◽  
Typing Methods ◽  
Paratyphi B ◽  
National Reference Center

ABSTRACT This study was conducted to investigate the occurrence of multiple-antibiotic resistance among 261 clinical isolates of Salmonella enterica serotype Paratyphi B strains collected between 2000 and 2003 through the network of the French National Reference Center for Salmonella. The 47 multidrug-resistant (MDR) isolates identified (18%), were characterized on the basis of the presence of several resistance genes (bla TEM, bla PSE-1, bla CTX-M, floR, aadA2, qacEΔ1, and sul1), the presence of Salmonella genomic island 1 (SGI1) by PCR mapping and hybridization, and the clonality of these isolates by several molecular (ribotyping, IS200 profiling, and pulsed-field gel electrophoresis [PFGE]) and phage typing methods. The results of PCR and Southern blot experiments indicated that 39 (83%) of the 47 S. enterica serotype Paratyphi B biotype Java MDR isolates possessed the SGI1 cluster (MDR/SGI1). Among these 39 MDR/SGI1 isolates, only 3 contained variations in SGI1, SGI1-B (n = 1) and SGI1-C (n = 2). The 39 MDR/SGI1 isolates showed the same specific PstI-IS200 profile 1, which contained seven copies from 2.6 to 18 kb. Two PstI ribotypes were found in MDR/SGI1 isolates, RP1 (n = 38) and RP6 (n = 1). Ribotype RP1 was also found in two susceptible strains. Analysis by PFGE using XbaI revealed that all the MDR/SGI1 isolates were grouped in two related clusters, with a similarity percentage of 82%. Isolation of MDR/SGI1 isolates in France was observed mainly between the second quarter of 2001 and the end of 2002. The source of the contamination has not been identified to date. A single isolate possessing the extended-spectrum β-lactamase bla CTX-M-15 gene was also identified during the study.

scholarly journals New variant Salmonella genomic island 1-U in Proteus mirabilis clinical and food isolates from South China

2011 ◽  
Vol 66 (5) ◽  
pp. 1178-1179 ◽  
Author(s):  
Shuilian Bi ◽  
He Yan ◽  
Miaorui Chen ◽  
Zhigang Zhang ◽  
Lei Shi ◽  
...  
Keyword(s):  
South China ◽  
Proteus Mirabilis ◽  
Genomic Island ◽  
New Variant
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