Antisense Oligonucleotide Blockade of Tumor Necrosis Factor-α in Two Murine Models of Colitis

2003 ◽  
Vol 304 (1) ◽  
pp. 411-424 ◽  
Author(s):  
Kathleen J. Myers ◽  
Sreekant Murthy ◽  
Anne Flanigan ◽  
Donna R. Witchell ◽  
Madeline Butler ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Murine Models ◽  
Factor Α ◽  
Necrosis Factor

Phase I Trial of ISIS 104838, a 2′-Methoxyethyl Modified Antisense Oligonucleotide Targeting Tumor Necrosis Factor-α

2002 ◽  
Vol 303 (3) ◽  
pp. 1334-1343 ◽  
Author(s):  
K. Lea Sewell ◽  
Richard S. Geary ◽  
Brenda F. Baker ◽  
Josephine M. Glover ◽  
Timothy G. K. Mant ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Phase I ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Phase I Trial ◽  
Factor Α ◽  
Necrosis Factor

PHARMACOKINETICS OF A TUMOR NECROSIS FACTOR-α PHOSPHOROTHIOATE 2′-O-(2-METHOXYETHYL) MODIFIED ANTISENSE OLIGONUCLEOTIDE: COMPARISON ACROSS SPECIES

2003 ◽  
Vol 31 (11) ◽  
pp. 1419-1428 ◽  
Author(s):  
Richard S. Geary ◽  
Rosie Z. Yu ◽  
Tanya Watanabe ◽  
Scott P. Henry ◽  
Greg E. Hardee ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor α Inhibits Expression of the Iron Regulating Hormone Hepcidin in Murine Models of Innate Colitis

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e38136 ◽  
Author(s):  
Nanda Kumar N. Shanmugam ◽  
Shiri Ellenbogen ◽  
Estela Trebicka ◽  
Lijian Wang ◽  
Subhankar Mukhopadhyay ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Murine Models ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Anti-inflammatory and Anti-arthritic Activities of Glycosylated Flavonoids from Syzygium jambos in Edematogenic Agent-Induced Paw Edema in Mice

2021 ◽  
Author(s):  
Luis Apaza Ticona ◽  
Beatriz Souto Pérez ◽  
Vanesa Martín Alejano ◽  
Karla Slowing
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Raw 264.7 ◽  
Murine Models ◽  
Syzygium Jambos ◽  
Raw 264.7 Cell ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Necrosis Factor

AbstractTwo glycosylated flavonoids, the quercetin-3-O-β-d-xylofuranosyl-(1 → 2)-α-l-rhamnopyranoside and myricetin-3-O-β-d-xylofuranosyl-(1 → 2)-α-l-rhamnopyranoside, were isolated from the CH2Cl2/MeOH fraction of Syzygium jambos (L.) Alston, Myrtaceae. The structures of these compounds were elucidated by spectroscopic means. The cytotoxicity of the compounds was evaluated against the RAW 264.7 cell lines by the lactate dehydrogenase assay. All analyzed compounds were less cytotoxic than the positive control (actinomycin D, CC50 = 0.008 μM). The anti-inflammatory and anti-arthritic activities were evaluated by measuring inflammatory parameters in murine models. The two glycosylated flavonoids inhibited the production of tumor necrosis factor-α in RAW 264.7 cell line with IC50 of 1.68 and 1.11 μM, respectively. In addition, all flavonoids decreased the levels of tumor necrosis factor-α, C-reactive protein, and fibrinogen at a dose of 5 mg/kg in murine models. Graphical abstract

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