Locally instilled tumor necrosis factor α antisense oligonucleotide contributes to inhibition of TH2-driven pulmonary fibrosis via induced CD4+CD25+Foxp3+regulatory T cells

2013 ◽  
Vol 15 (11-12) ◽  
pp. 441-452 ◽  
Author(s):  
Yi Luo ◽  
Min Wang ◽  
Zhonghua Pang ◽  
Fengtao Jiang ◽  
Jiangning Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
Pulmonary Fibrosis ◽  
Regulatory T Cells ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor α and Regulatory T Cells in Oncoimmunology

2018 ◽  
Vol 9 ◽  
Author(s):  
Benoît L. Salomon ◽  
Mathieu Leclerc ◽  
Jimena Tosello ◽  
Emilie Ronin ◽  
Eliane Piaggio ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
Regulatory T Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

The Effect of Blockade of Tumor Necrosis Factor α on VLA-1+T-Cells in Rheumatoid Arthritis Patients

2007 ◽  
Vol 27 (6) ◽  
pp. 580-588 ◽  
Author(s):  
Ilan Bank ◽  
Shomron Ben-Horin ◽  
Itamar Goldstein ◽  
Alexander Koltakov ◽  
Pnina Langevitz ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

Phase I Trial of ISIS 104838, a 2′-Methoxyethyl Modified Antisense Oligonucleotide Targeting Tumor Necrosis Factor-α

2002 ◽  
Vol 303 (3) ◽  
pp. 1334-1343 ◽  
Author(s):  
K. Lea Sewell ◽  
Richard S. Geary ◽  
Brenda F. Baker ◽  
Josephine M. Glover ◽  
Timothy G. K. Mant ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Phase I ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Phase I Trial ◽  
Factor Α ◽  
Necrosis Factor

Apolipoprotein A-I inhibits the production of interleukin-1β and tumor necrosis factor-α by blocking contact-mediated activation of monocytes by T lymphocytes

Blood ◽  
2001 ◽  
Vol 97 (8) ◽  
pp. 2381-2389 ◽  
Author(s):  
Nevila Hyka ◽  
Jean-Michel Dayer ◽  
Christine Modoux ◽  
Tadahiko Kohno ◽  
Carl K. Edwards ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
T Lymphocytes ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 1Β ◽  
Apolipoprotein A ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Abstract Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), essential components in the pathogenesis of immunoinflammatory diseases, are strongly induced in monocytes by direct contact with stimulated T lymphocytes. This study demonstrates that adult human serum (HS) but not fetal calf or cord blood serum displays inhibitory activity toward the contact-mediated activation of monocytes by stimulated T cells, decreasing the production of both TNF-α and IL-1β. Fractionation of HS and N-terminal microsequencing as well as electroelution of material subjected to preparative electrophoresis revealed that apolipoprotein A-I (apo A-I), a “negative” acute-phase protein, was the inhibitory factor. Functional assays and flow cytometry analyses show that high-density lipoprotein (HDL)-associated apo A-I inhibits contact-mediated activation of monocytes by binding to stimulated T cells, thus inhibiting TNF-α and IL-1β production at both protein and messenger RNA levels. Furthermore, apo A-I inhibits monocyte inflammatory functions in peripheral blood mononuclear cells activated by either specific antigens or lectins without affecting cell proliferation. These results demonstrate a new anti-inflammatory activity of HDL-associated apo A-I that might have modulating functions in nonseptic conditions. Therefore, because HDL has been shown to bind and neutralize lipopolysaccharide, HDL appears to play an important part in modulating both acute and chronic inflammation. The novel anti-inflammatory function of apo A-I reported here might lead to new therapeutic approaches in inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, and atherosclerosis.

Beryllium-Induced Tumor Necrosis Factor-α Production by CD4+T Cells Is Mediated by HLA-DP

2004 ◽  
Vol 31 (1) ◽  
pp. 122-130 ◽  
Author(s):  
Richard T. Sawyer ◽  
Charles E. Parsons ◽  
Andrew P. Fontenot ◽  
Lisa A. Maier ◽  
May M. Gillespie ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
Cd4 T Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor
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