Locally instilled tumor necrosis factor-α antisense oligonucleotide inhibits allergic inflammation via the induction of Tregs

2012 ◽  
Vol 14 (6) ◽  
pp. 374-383 ◽  
Author(s):  
Yi Luo ◽  
Zhonghua Pang ◽  
Qian Zhu ◽  
Xing Cai ◽  
Yuan Yin ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Allergic Inflammation ◽  
Factor Α ◽  
Necrosis Factor

Phase I Trial of ISIS 104838, a 2′-Methoxyethyl Modified Antisense Oligonucleotide Targeting Tumor Necrosis Factor-α

2002 ◽  
Vol 303 (3) ◽  
pp. 1334-1343 ◽  
Author(s):  
K. Lea Sewell ◽  
Richard S. Geary ◽  
Brenda F. Baker ◽  
Josephine M. Glover ◽  
Timothy G. K. Mant ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Phase I ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Phase I Trial ◽  
Factor Α ◽  
Necrosis Factor

PHARMACOKINETICS OF A TUMOR NECROSIS FACTOR-α PHOSPHOROTHIOATE 2′-O-(2-METHOXYETHYL) MODIFIED ANTISENSE OLIGONUCLEOTIDE: COMPARISON ACROSS SPECIES

2003 ◽  
Vol 31 (11) ◽  
pp. 1419-1428 ◽  
Author(s):  
Richard S. Geary ◽  
Rosie Z. Yu ◽  
Tanya Watanabe ◽  
Scott P. Henry ◽  
Greg E. Hardee ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

Antisense Oligonucleotide Blockade of Tumor Necrosis Factor-α in Two Murine Models of Colitis

2003 ◽  
Vol 304 (1) ◽  
pp. 411-424 ◽  
Author(s):  
Kathleen J. Myers ◽  
Sreekant Murthy ◽  
Anne Flanigan ◽  
Donna R. Witchell ◽  
Madeline Butler ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Murine Models ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants

Immunity ◽  
2019 ◽  
Vol 50 (1) ◽  
pp. 225-240.e4 ◽  
Author(s):  
Holly Bachus ◽  
Kamaljeet Kaur ◽  
Amber M. Papillion ◽  
Tatiana T. Marquez-Lago ◽  
Zhihong Yu ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Cell Activation ◽  
Tumor Necrosis Factor Α ◽  
Allergic Inflammation ◽  
Dendritic Cell Activation ◽  
Factor Α ◽  
Necrosis Factor

Chronic bronchial allergic inflammation increases alveolar liquid clearance by TNF-α-dependent mechanism

2002 ◽  
Vol 283 (6) ◽  
pp. L1303-L1309 ◽  
Author(s):  
Isabelle Tillie-Leblond ◽  
Benoit P. H. Guery ◽  
Anne Janin ◽  
Rozenn Leberre ◽  
Nicolas Just ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Allergic Inflammation ◽  
Endothelial Permeability ◽  
Fluid Movement ◽  
Factor Α ◽  
Alveolar Liquid Clearance ◽  
Necrosis Factor ◽  
Alveolar Liquid

Bronchial inflammation in allergic asthma is associated with active exudation from the bronchial tree into the interstitial space of both mucosa and submucosa. The aim of this study was to evaluate epithelial and endothelial permeability as well as alveolar fluid movement in a model of chronic allergic inflammation in Brown-Norway rats sensitized and challenged with ovalbumin (OA). Control groups were challenged with saline solution (C), and rats were immunized by OA but not challenged (Se). Lung sections showed a marked inflammatory infiltrate associated with perivascular and peribronchiolar edema in OA. To measure alveolar liquid clearance, a 5% bovine albumin solution with 1 μCi of125I-labeled human albumin was instilled into the air spaces. Alveolar-capillary barrier permeability was evaluated by intravascular injection of 1 μCi of 131I-labeled albumin. Endothelial permeability was significantly increased in OA, from 0.08 ± 0.01 in the C group to 0.19 ± 0.03 in OA group ( P < 0.05). Final-to-initial protein ratio was also statistically higher in OA (1.6 ± 0.05) compared with C (1.38 ± 0.03, P = 0.01) and Se groups (1.42 ± 0.03, P = 0.04). Administration of anti-tumor necrosis factor-α antibodies within the instillate significantly decreased this ratio (1.32 ± 0.08, P = 0.003 vs. OA). To conclude, we demonstrated a tumor necrosis factor-α-dependent increase in alveolar fluid movement in a model of severe bronchial allergic inflammation associated with endothelial and epithelial leakage.

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