PHARMACOKINETICS OF A TUMOR NECROSIS FACTOR-α PHOSPHOROTHIOATE 2′-O-(2-METHOXYETHYL) MODIFIED ANTISENSE OLIGONUCLEOTIDE: COMPARISON ACROSS SPECIES

2003 ◽  
Vol 31 (11) ◽  
pp. 1419-1428 ◽  
Author(s):  
Richard S. Geary ◽  
Rosie Z. Yu ◽  
Tanya Watanabe ◽  
Scott P. Henry ◽  
Greg E. Hardee ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

Phase I Trial of ISIS 104838, a 2′-Methoxyethyl Modified Antisense Oligonucleotide Targeting Tumor Necrosis Factor-α

2002 ◽  
Vol 303 (3) ◽  
pp. 1334-1343 ◽  
Author(s):  
K. Lea Sewell ◽  
Richard S. Geary ◽  
Brenda F. Baker ◽  
Josephine M. Glover ◽  
Timothy G. K. Mant ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Phase I ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Phase I Trial ◽  
Factor Α ◽  
Necrosis Factor

Antisense Oligonucleotide Blockade of Tumor Necrosis Factor-α in Two Murine Models of Colitis

2003 ◽  
Vol 304 (1) ◽  
pp. 411-424 ◽  
Author(s):  
Kathleen J. Myers ◽  
Sreekant Murthy ◽  
Anne Flanigan ◽  
Donna R. Witchell ◽  
Madeline Butler ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Antisense Oligonucleotide ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Murine Models ◽  
Factor Α ◽  
Necrosis Factor
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