scholarly journals NADPH-Independent Inactivation of CYP2B6 and NADPH-Dependent Inactivation of CYP3A4/5 by PBD: Potential Implication for Assessing Covalent Modulators for Time-Dependent Inhibition

2020 ◽  
Vol 48 (8) ◽  
pp. 655-661
Author(s):  
Mika Kosaka ◽  
Donglu Zhang ◽  
Simon Wong ◽  
Zhengyin Yan
Keyword(s):  
Time Dependent ◽  
Potential Implication ◽  
Dependent Inactivation ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Combination of GSH Trapping and Time-Dependent Inhibition Assays as a Predictive Method of Drugs Generating Highly Reactive Metabolites

2011 ◽  
Vol 39 (7) ◽  
pp. 1247-1254 ◽  
Author(s):  
Shintaro Nakayama ◽  
Hideo Takakusa ◽  
Akiko Watanabe ◽  
Yoshihiro Miyaji ◽  
Wataru Suzuki ◽  
...  
Keyword(s):  
Time Dependent ◽  
Reactive Metabolites ◽  
Predictive Method ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Time-Dependent Inhibition of Oxotremorine-Induced Cerebral Hyperemia by N ω -Nitro- l -Arginine in Cats

Stroke ◽  
1995 ◽  
Vol 26 (11) ◽  
pp. 2160-2165 ◽  
Author(s):  
Charisse S. Tietjen ◽  
Jeffrey R. Kirsch ◽  
Nathalie Clavier ◽  
Richard J. Traystman
Keyword(s):  
Time Dependent ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition
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