Numerical Analysis of Time-Dependent Inhibition by MDMA

John T. Rodgers; Jeffrey P. Jones

doi:10.1124/dmd.119.089268

Numerical Analysis of Time-Dependent Inhibition by MDMA

Drug Metabolism and Disposition ◽

10.1124/dmd.119.089268 ◽

2019 ◽

Vol 48 (1) ◽

pp. 1-7

Author(s):

John T. Rodgers ◽

Jeffrey P. Jones

Keyword(s):

Numerical Analysis ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Numerical analysis of time-dependent inhibition kinetics: comparison between rat liver microsomes and rat hepatocyte data for mechanistic model fitting

Xenobiotica ◽

10.1080/00498254.2017.1345020 ◽

2020 ◽

Vol 50 (11) ◽

pp. 1301-1310 ◽

Cited By ~ 3

Author(s):

Chuong Pham ◽

Swati Nagar ◽

Ken Korzekwa

Keyword(s):

Numerical Analysis ◽

Mechanistic Model ◽

Liver Microsomes ◽

Model Fitting ◽

Time Dependent ◽

Rat Liver Microsomes ◽

Inhibition Kinetics ◽

Rat Hepatocyte ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Human Hepatocyte Suspensions as a Model to Assess Reversible and Time-Dependent Inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4

10.26226/morressier.57ea3d69d462b8028d88e3cf ◽

2016 ◽

Author(s):

George Zhang

Keyword(s):

Human Hepatocyte ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Statistical Methods for Analysis of Time-Dependent Inhibition of Cytochrome P450 Enzymes

Drug Metabolism and Disposition ◽

10.1124/dmd.112.047233 ◽

2012 ◽

Vol 40 (12) ◽

pp. 2289-2296 ◽

Cited By ~ 15

Author(s):

Phillip Yates ◽

Heather Eng ◽

Li Di ◽

R. Scott Obach

Keyword(s):

Cytochrome P450 ◽

Statistical Methods ◽

Time Dependent ◽

Cytochrome P450 Enzymes ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Time-dependent inhibition of hindlimb somatic afferent transmission within nucleus tractus solitarius: An in vivo intracellular recording study

Neuroscience ◽

10.1016/0306-4522(95)00156-d ◽

1995 ◽

Vol 68 (2) ◽

pp. 445-453 ◽

Cited By ~ 17

Author(s):

G.M. Toney ◽

S.W. Mifflin

Keyword(s):

Intracellular Recording ◽

Nucleus Tractus Solitarius ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Combination of GSH Trapping and Time-Dependent Inhibition Assays as a Predictive Method of Drugs Generating Highly Reactive Metabolites

Drug Metabolism and Disposition ◽

10.1124/dmd.111.039180 ◽

2011 ◽

Vol 39 (7) ◽

pp. 1247-1254 ◽

Cited By ~ 20

Author(s):

Shintaro Nakayama ◽

Hideo Takakusa ◽

Akiko Watanabe ◽

Yoshihiro Miyaji ◽

Wataru Suzuki ◽

...

Keyword(s):

Time Dependent ◽

Reactive Metabolites ◽

Predictive Method ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Effect of Solvents on the Time-Dependent Inhibition of CYP3A4 and the Biotransformation of AZD3839 in Human Liver Microsomes and Hepatocytes

Drug Metabolism and Disposition ◽

10.1124/dmd.112.047597 ◽

2012 ◽

Vol 41 (1) ◽

pp. 159-169 ◽

Cited By ~ 5

Author(s):

Jenny Aasa ◽

Yin Hu ◽

Göran Eklund ◽

Anders Lindgren ◽

Pawel Baranczewski ◽

...

Keyword(s):

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Time Dependent ◽

Effect Of Solvents ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Time-dependent inhibition of Bacillus stearothermophilus alanine racemase by (1-aminoethyl)phosphonate isomers by isomerization to noncovalent slowly dissociating enzyme-(1-aminoethyl)phosphonate complexes

Biochemistry ◽

10.1021/bi00359a029 ◽

1986 ◽

Vol 25 (11) ◽

pp. 3275-3282 ◽

Cited By ~ 43

Author(s):

Bernard Badet ◽

Kenji Inagaki ◽

Kenji Soda ◽

Christopher T. Walsh

Keyword(s):

Bacillus Stearothermophilus ◽

Time Dependent ◽

Alanine Racemase ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Time-Dependent Inhibition of Oxotremorine-Induced Cerebral Hyperemia by N ω -Nitro- l -Arginine in Cats

Stroke ◽

10.1161/01.str.26.11.2160 ◽

1995 ◽

Vol 26 (11) ◽

pp. 2160-2165 ◽

Cited By ~ 4

Author(s):

Charisse S. Tietjen ◽

Jeffrey R. Kirsch ◽

Nathalie Clavier ◽

Richard J. Traystman

Keyword(s):

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions

Clinical Pharmacokinetics ◽

10.1007/s40262-019-00856-z ◽

2019 ◽

Vol 59 (6) ◽

pp. 781-808 ◽

Cited By ~ 5

Author(s):

Xia Li ◽

Sebastian Frechen ◽

Daniel Moj ◽

Thorsten Lehr ◽

Max Taubert ◽

...

Keyword(s):

Drug Interactions ◽

Genetic Polymorphisms ◽

Pharmacokinetic Model ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Assessment of CYP3A4 Time-Dependent Inhibition in Plated and Suspended Human Hepatocytes

Methods in Pharmacology and Toxicology - Optimization in Drug Discovery ◽

10.1007/978-1-62703-742-6_15 ◽

2013 ◽

pp. 255-268

Author(s):

J. George Zhang ◽

David M. Stresser

Keyword(s):

Human Hepatocytes ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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