SU-G-IeP1-12: Size Selective Arterial Cerebral Blood Volume Mapping Using Multiple Inversion Time Arterial Spin Labeling

2016 ◽  
Vol 43 (6Part25) ◽  
pp. 3647-3647
Author(s):  
Y Jung ◽  
M Johnston ◽  
H Liu ◽  
C Whitlow
Keyword(s):  
Blood Volume ◽  
Arterial Spin Labeling ◽  
Cerebral Blood Volume ◽  
Spin Labeling ◽  
Inversion Time

Sensitivity comparison of multiple vs. single inversion time pulsed arterial spin labeling fMRI

2007 ◽  
Vol 25 (1) ◽  
pp. 215-221 ◽  
Author(s):  
Matthias J.P. van Osch ◽  
Jeroen Hendrikse ◽  
Jeroen van der Grond
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Inversion Time

Partial volume correction of multiple inversion time arterial spin labeling MRI data

2011 ◽  
Vol 65 (4) ◽  
pp. 1173-1183 ◽  
Author(s):  
M. A. Chappell ◽  
A. R. Groves ◽  
B. J. MacIntosh ◽  
M. J. Donahue ◽  
P. Jezzard ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Partial Volume Correction ◽  
Partial Volume ◽  
Volume Correction ◽  
Inversion Time

scholarly journals Noninvasive Assessment of Arterial Compliance of Human Cerebral Arteries with Short Inversion Time Arterial Spin Labeling

2015 ◽  
Vol 35 (3) ◽  
pp. 461-468 ◽  
Author(s):  
Esther AH Warnert ◽  
Kevin Murphy ◽  
Judith E Hall ◽  
Richard G Wise
Keyword(s):  
Arterial Spin Labeling ◽  
Arterial Input Function ◽  
Arterial Compliance ◽  
Cerebral Arteries ◽  
Spin Labeling ◽  
Input Function ◽  
Inversion Time ◽  
Arterial Blood ◽  
Left Posterior ◽  
Middle Cerebral Arteries

A noninvasive method of assessing cerebral arterial compliance (AC) is introduced in which arterial spin labeling (ASL) is used to measure changes in arterial blood volume (aBV) occurring within the cardiac cycle. Short inversion time pulsed ASL (PASL) was performed in healthy volunteers with inversion times ranging from 250 to 850 ms. A model of the arterial input function was used to obtain the cerebral aBV. Results indicate that aBV depends on the cardiac phase of the arteries in the imaging volume. Cerebral AC, estimated from aBV and brachial blood pressure measured noninvasively in systole and diastole, was assessed in the flow territories of the basal cerebral arteries originating from the circle of Willis: right and left middle cerebral arteries (RMCA and LMCA), right and left posterior cerebral arteries (RPCA and LPCA), and the anterior cerebral artery (ACA). Group average AC values calculated for the RMCA, LMCA, ACA, RPCA, and LPCA were 0.56%±0.2%, 0.50%±0.3%, 0.4%±0.2%, 1.1%±0.5%, and 1.1%±0.3% per mm Hg, respectively. The current experiment has shown the feasibility of measuring AC of cerebral arteries with short inversion time PASL.

scholarly journals Quantitative Functional Magnetic Resonance Imaging of Brain Activity Using Bolus-Tracking Arterial Spin Labeling

2010 ◽  
Vol 30 (5) ◽  
pp. 913-922 ◽  
Author(s):  
Michael E Kelly ◽  
Christoph W Blau ◽  
Karen M Griffin ◽  
Oliviero L Gobbo ◽  
James FX Jones ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Resting State ◽  
Arterial Spin Labeling ◽  
Cerebral Blood Volume ◽  
Spin Labeling ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Perfusion Coefficient

Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) is the most widely used method for mapping neural activity in the brain. The interpretation of altered BOLD signals is problematic when cerebral blood flow (CBF) or cerebral blood volume change because of aging and/or neurodegenerative diseases. In this study, a recently developed quantitative arterial spin labeling (ASL) approach, bolus-tracking ASL (btASL), was applied to an fMRI experiment in the rat brain. The mean transit time (MTT), capillary transit time (CTT), relative cerebral blood volume of labeled water (rCBVlw), relative cerebral blood flow (rCBF), and perfusion coefficient in the forelimb region of the somatosensory cortex were quantified during neuronal activation and in the resting state. The average MTT and CTT were 1.939±0.175 and 1.606±0.106 secs, respectively, in the resting state. Both times decreased significantly to 1.616±0.207 and 1.305±0.201 secs, respectively, during activation. The rCBVlw, rCBF, and perfusion coefficient increased on average by a factor of 1.123±0.006, 1.353±0.078, and 1.479±0.148, respectively, during activation. In contrast to BOLD techniques, btASL yields physiologically relevant indices of the functional hyperemia that accompanies neuronal activation.

Sign in / Sign up

Export Citation Format

Share Document