scholarly journals Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI

2020 ◽  
Vol 11 ◽  
Author(s):  
Catherine Foster ◽  
Jessica J. Steventon ◽  
Daniel Helme ◽  
Valentina Tomassini ◽  
Richard G. Wise
Keyword(s):  
Young Adults ◽  
Aerobic Fitness ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Inversion Time ◽  
Cerebrovascular Function

scholarly journals Assessment of the effects of aerobic fitness on cerebrovascular function in young adults using multiple inversion time arterial spin labelling MRI

2019 ◽  
Author(s):  
Catherine Foster ◽  
Jessica J Steventon ◽  
Daniel Helme ◽  
Valentina Tomassini ◽  
Richard G. Wise
Keyword(s):  
Young Adults ◽  
Aerobic Fitness ◽  
Arterial Spin Labelling ◽  
Cerebrovascular Reactivity ◽  
Inverse Association ◽  
Cross Sectional ◽  
Whole Brain ◽  
Inversion Time ◽  
Cerebrovascular Function ◽  
Spin Labelling

AbstractThe cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in the healthy brain. We quantified grey matter (GM) cerebral blood flow (CBF) and cerebrovascular reactivity (CVR), in a sample of young adults within a normal fitness range. Based on existing TCD and fMRI evidence, we predicted a positive relationship between fitness and resting GM CBF, and CVR. Exploratory hypotheses that higher peak would be associated with higher GM volume and cognitive performance were also investigated.20 adults underwent a peak test and a battery of cognitive tests. All subjects underwent an MRI scan where multiple inversion time (MTI) pulsed arterial spin labelling (PASL) was used to quantify resting CBF and CVR to 5% CO2.ROI analysis showed a non-significant negative correlation between whole-brain GM CBF and peak; r=-0.4, p=0.08, corrected p (p’) =0.16 and a significant positive correlation between peak and voxelwise whole-brain GM CVR; r=0.62, p=0.003, p’ =0.006. Voxelwise analysis revealed a significant inverse association between peak and resting CBF in the left and right thalamus, brainstem, right lateral occipital cortex, left intracalcarine cortex and cerebellum. The results of this study suggest that aerobic fitness is associated with lower CBF and greater CVR in young adults.

Sensitivity comparison of multiple vs. single inversion time pulsed arterial spin labeling fMRI

2007 ◽  
Vol 25 (1) ◽  
pp. 215-221 ◽  
Author(s):  
Matthias J.P. van Osch ◽  
Jeroen Hendrikse ◽  
Jeroen van der Grond
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Inversion Time

scholarly journals Acute Effects of Alcohol on Brain Perfusion Monitored with Arterial Spin Labeling Magnetic Resonance Imaging in Young Adults

2014 ◽  
Vol 34 (3) ◽  
pp. 472-479 ◽  
Author(s):  
Michael Marxen ◽  
Gabriela Gan ◽  
Daniel Schwarz ◽  
Eva Mennigen ◽  
Maximilian Pilhatsch ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Young Adults ◽  
Magnetic Resonance ◽  
Arterial Spin Labeling ◽  
Time Course ◽  
Regional Distribution ◽  
Brain Perfusion ◽  
Spin Labeling ◽  
Acute Tolerance ◽  
Resonance Imaging

While a number of studies have established that moderate doses of alcohol increase brain perfusion, the time course of such an increase as a function of breath alcohol concentration (BrAC) has not yet been investigated, and studies differ about regional effects. Using arterial spin labeling (ASL) magnetic resonance imaging, we investigated (1) the time course of the perfusion increase during a 15-minute linear increase of BrAC up to 0.6 g/kg followed by a steady exposure of 100 minutes, (2) the regional distribution, (3) a potential gender effect, and (4) the temporal stability of perfusion effects. In 48 young adults who participated in the Dresden longitudinal study on alcohol effects in young adults, we observed (1) a 7% increase of global perfusion as compared with placebo and that perfusion and BrAC are tightly coupled in time, (2) that the increase reaches significance in most regions of the brain, (3) that the effect is stronger in women than in men, and (4) that an acute tolerance effect is not observable on the time scale of 2 hours. Larger studies are needed to investigate the origin and the consequences of the effect, as well as the correlates of inter-subject variations.

Partial volume correction of multiple inversion time arterial spin labeling MRI data

2011 ◽  
Vol 65 (4) ◽  
pp. 1173-1183 ◽  
Author(s):  
M. A. Chappell ◽  
A. R. Groves ◽  
B. J. MacIntosh ◽  
M. J. Donahue ◽  
P. Jezzard ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Partial Volume Correction ◽  
Partial Volume ◽  
Volume Correction ◽  
Inversion Time

scholarly journals Noninvasive Assessment of Arterial Compliance of Human Cerebral Arteries with Short Inversion Time Arterial Spin Labeling

2015 ◽  
Vol 35 (3) ◽  
pp. 461-468 ◽  
Author(s):  
Esther AH Warnert ◽  
Kevin Murphy ◽  
Judith E Hall ◽  
Richard G Wise
Keyword(s):  
Arterial Spin Labeling ◽  
Arterial Input Function ◽  
Arterial Compliance ◽  
Cerebral Arteries ◽  
Spin Labeling ◽  
Input Function ◽  
Inversion Time ◽  
Arterial Blood ◽  
Left Posterior ◽  
Middle Cerebral Arteries

A noninvasive method of assessing cerebral arterial compliance (AC) is introduced in which arterial spin labeling (ASL) is used to measure changes in arterial blood volume (aBV) occurring within the cardiac cycle. Short inversion time pulsed ASL (PASL) was performed in healthy volunteers with inversion times ranging from 250 to 850 ms. A model of the arterial input function was used to obtain the cerebral aBV. Results indicate that aBV depends on the cardiac phase of the arteries in the imaging volume. Cerebral AC, estimated from aBV and brachial blood pressure measured noninvasively in systole and diastole, was assessed in the flow territories of the basal cerebral arteries originating from the circle of Willis: right and left middle cerebral arteries (RMCA and LMCA), right and left posterior cerebral arteries (RPCA and LPCA), and the anterior cerebral artery (ACA). Group average AC values calculated for the RMCA, LMCA, ACA, RPCA, and LPCA were 0.56%±0.2%, 0.50%±0.3%, 0.4%±0.2%, 1.1%±0.5%, and 1.1%±0.3% per mm Hg, respectively. The current experiment has shown the feasibility of measuring AC of cerebral arteries with short inversion time PASL.

Arterial Spin Labeling Perfusion MRI in Children and Young Adults with Previous Ischemic Stroke and Unilateral Intracranial Arteriopathy

2014 ◽  
Vol 37 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Marcel M.M. Bulder ◽  
Reinoud P.H. Bokkers ◽  
Jeroen Hendrikse ◽  
L. Jaap Kappelle ◽  
Kees P.J. Braun ◽  
...  
Keyword(s):  
Young Adults ◽  
Ischemic Stroke ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Perfusion Mri ◽  
Children And Young Adults

Association between aerobic fitness and cerebrovascular function with neurocognitive functions in healthy, young adults

2018 ◽  
Vol 236 (5) ◽  
pp. 1421-1430 ◽  
Author(s):  
Jungyun Hwang ◽  
Kiyoung Kim ◽  
R. Matthew Brothers ◽  
Darla M. Castelli ◽  
F. Gonzalez-Lima
Keyword(s):  
Young Adults ◽  
Aerobic Fitness ◽  
Neurocognitive Functions ◽  
Cerebrovascular Function
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