Sensitivity comparison of multiple vs. single inversion time pulsed arterial spin labeling fMRI

2007 ◽  
Vol 25 (1) ◽  
pp. 215-221 ◽  
Author(s):  
Matthias J.P. van Osch ◽  
Jeroen Hendrikse ◽  
Jeroen van der Grond
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Inversion Time

Partial volume correction of multiple inversion time arterial spin labeling MRI data

2011 ◽  
Vol 65 (4) ◽  
pp. 1173-1183 ◽  
Author(s):  
M. A. Chappell ◽  
A. R. Groves ◽  
B. J. MacIntosh ◽  
M. J. Donahue ◽  
P. Jezzard ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Partial Volume Correction ◽  
Partial Volume ◽  
Volume Correction ◽  
Inversion Time

scholarly journals Noninvasive Assessment of Arterial Compliance of Human Cerebral Arteries with Short Inversion Time Arterial Spin Labeling

2015 ◽  
Vol 35 (3) ◽  
pp. 461-468 ◽  
Author(s):  
Esther AH Warnert ◽  
Kevin Murphy ◽  
Judith E Hall ◽  
Richard G Wise
Keyword(s):  
Arterial Spin Labeling ◽  
Arterial Input Function ◽  
Arterial Compliance ◽  
Cerebral Arteries ◽  
Spin Labeling ◽  
Input Function ◽  
Inversion Time ◽  
Arterial Blood ◽  
Left Posterior ◽  
Middle Cerebral Arteries

A noninvasive method of assessing cerebral arterial compliance (AC) is introduced in which arterial spin labeling (ASL) is used to measure changes in arterial blood volume (aBV) occurring within the cardiac cycle. Short inversion time pulsed ASL (PASL) was performed in healthy volunteers with inversion times ranging from 250 to 850 ms. A model of the arterial input function was used to obtain the cerebral aBV. Results indicate that aBV depends on the cardiac phase of the arteries in the imaging volume. Cerebral AC, estimated from aBV and brachial blood pressure measured noninvasively in systole and diastole, was assessed in the flow territories of the basal cerebral arteries originating from the circle of Willis: right and left middle cerebral arteries (RMCA and LMCA), right and left posterior cerebral arteries (RPCA and LPCA), and the anterior cerebral artery (ACA). Group average AC values calculated for the RMCA, LMCA, ACA, RPCA, and LPCA were 0.56%±0.2%, 0.50%±0.3%, 0.4%±0.2%, 1.1%±0.5%, and 1.1%±0.3% per mm Hg, respectively. The current experiment has shown the feasibility of measuring AC of cerebral arteries with short inversion time PASL.

scholarly journals Impact of the inversion time on regional brain perfusion estimation with clinical arterial spin labeling protocols

2021 ◽  
Author(s):  
Francesco Sanvito ◽  
Fulvia Palesi ◽  
Elisa Rognone ◽  
Leonardo Barzaghi ◽  
Ludovica Pasca ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Insular Cortex ◽  
Brain Perfusion ◽  
Occipital Cortex ◽  
Spin Labeling ◽  
Patient Specific ◽  
Visual Evaluation ◽  
Inversion Time ◽  
Arterial Transit Time ◽  
The Impact

Abstract Objective Evaluating the impact of the Inversion Time (TI) on regional perfusion estimation in a pediatric cohort using Arterial Spin Labeling (ASL). Materials and methods Pulsed ASL (PASL) was acquired at 3 T both at TI 1500 ms and 2020 ms from twelve MRI-negative patients (age range 9–17 years). A volume of interest (VOIs) and a voxel-wise approach were employed to evaluate subject-specific TI-dependent Cerebral Blood Flow (CBF) differences, and grey matter CBF Z-score differences. A visual evaluation was also performed. Results CBF was higher for TI 1500 ms in the proximal territories of the arteries (PTAs) (e.g. insular cortex and basal ganglia — P < 0.01 and P < 0.05 from the VOI analysis, respectively), and for TI 2020 ms in the distal territories of the arteries (DTAs), including the watershed areas (e.g. posterior parietal and occipital cortex — P < 0.001 and P < 0.01 from the VOI analysis, respectively). Similar differences were also evident when analyzing patient-specific CBF Z-scores and at a visual inspection. Conclusions TI influences ASL perfusion estimates with a region-dependent effect. The presence of intraluminal arterial signal in PTAs and the longer arterial transit time in the DTAs (including watershed areas) may account for the TI-dependent differences. Watershed areas exhibiting a lower perfusion signal at short TIs (~ 1500 ms) should not be misinterpreted as focal hypoperfused areas.

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