scholarly journals Noninvasive measurement of arterial cerebral blood volume using look-locker EPI and arterial spin labeling

2007 ◽  
Vol 58 (1) ◽  
pp. 41-54 ◽  
Author(s):  
M.J. Brookes ◽  
P.G. Morris ◽  
P.A. Gowland ◽  
S.T. Francis
Keyword(s):  
Blood Volume ◽  
Arterial Spin Labeling ◽  
Cerebral Blood Volume ◽  
Spin Labeling ◽  
Noninvasive Measurement

scholarly journals Quantitative Functional Magnetic Resonance Imaging of Brain Activity Using Bolus-Tracking Arterial Spin Labeling

2010 ◽  
Vol 30 (5) ◽  
pp. 913-922 ◽  
Author(s):  
Michael E Kelly ◽  
Christoph W Blau ◽  
Karen M Griffin ◽  
Oliviero L Gobbo ◽  
James FX Jones ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Resting State ◽  
Arterial Spin Labeling ◽  
Cerebral Blood Volume ◽  
Spin Labeling ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Perfusion Coefficient

Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) is the most widely used method for mapping neural activity in the brain. The interpretation of altered BOLD signals is problematic when cerebral blood flow (CBF) or cerebral blood volume change because of aging and/or neurodegenerative diseases. In this study, a recently developed quantitative arterial spin labeling (ASL) approach, bolus-tracking ASL (btASL), was applied to an fMRI experiment in the rat brain. The mean transit time (MTT), capillary transit time (CTT), relative cerebral blood volume of labeled water (rCBVlw), relative cerebral blood flow (rCBF), and perfusion coefficient in the forelimb region of the somatosensory cortex were quantified during neuronal activation and in the resting state. The average MTT and CTT were 1.939±0.175 and 1.606±0.106 secs, respectively, in the resting state. Both times decreased significantly to 1.616±0.207 and 1.305±0.201 secs, respectively, during activation. The rCBVlw, rCBF, and perfusion coefficient increased on average by a factor of 1.123±0.006, 1.353±0.078, and 1.479±0.148, respectively, during activation. In contrast to BOLD techniques, btASL yields physiologically relevant indices of the functional hyperemia that accompanies neuronal activation.

Noninvasive Measurement of Cerebral Blood Flow Under Anesthesia Using Arterial Spin Labeling MRI

2016 ◽  
Vol 28 (4) ◽  
pp. 331-336 ◽  
Author(s):  
Lashmi Venkatraghavan ◽  
Julien Poublanc ◽  
Suparna Bharadwaj ◽  
Olivia Sobczyk ◽  
Adrian P. Crawley ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Noninvasive Measurement

scholarly journals Comparison of Velocity- and Acceleration-Selective Arterial Spin Labeling with [15O]H2O Positron Emission Tomography

2015 ◽  
Vol 35 (8) ◽  
pp. 1296-1303 ◽  
Author(s):  
Sophie Schmid ◽  
Dennis FR Heijtel ◽  
Henri JMM Mutsaerts ◽  
Ronald Boellaard ◽  
Adriaan A Lammertsma ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Arterial Spin Labeling ◽  
Cerebral Blood Volume ◽  
Spin Labeling ◽  
Emission Tomography ◽  
Minor Contribution ◽  
Positron Emission ◽  
Delay Effects ◽  
Transit Delay ◽  
Imaging Plane

In the last decade spatially nonselective arterial spin labeling (SNS-ASL) methods such as velocity-selective ASL (VS-ASL) and acceleration-selective ASL have been introduced, which label spins based on their flow velocity or acceleration rather than spatial localization. Since labeling also occurs within the imaging plane, these methods suffer less from transit delay effects than traditional ASL methods. However, there is a need for validation of these techniques. In this study, a comparison was made between these SNS-ASL techniques with [15O]H2O positron emission tomography (PET), which is regarded as gold standard to measure quantitatively cerebral blood flow (CBF) in humans. In addition, the question of whether these techniques suffered from sensitivity to arterial cerebral blood volume (aCBV), as opposed to producing pure CBF contrast, was investigated. The results show high voxelwise intracranial correlation (0.72 to 0.89) between the spatial distribution of the perfusion signal from the SNS-ASL methods and the PET CBF maps. A similar gray matter (GM) CBF was measured by dual VS-ASL compared with PET (46.7 ± 4.1 versus 47.1 ± 6.5 mL/100 g/min, respectively). Finally, only minor contribution of aCBV patterns in GM to all SNS-ASL methods was found compared with pseudo-continuous ASL. In conclusion, VS-ASL provides a similar quantitative CBF, and all SNS-ASL methods provide qualitatively similar CBF maps as [15O]H2O PET.

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