3D nanoporous optofluidic device for high sensitivity SERS detection

2012 ◽  
Author(s):  
Soroush H. Yazdi ◽  
Ian M. White
Keyword(s):  
High Sensitivity ◽  
Sers Detection

Advanced Design of Microfluidic Chip Based on SPP-LSP Plasmonic Coupling for SERS Detection with High Sensitivity and Reliability

2019 ◽  
Vol 123 (50) ◽  
pp. 30492-30498 ◽  
Author(s):  
V. Burtsev ◽  
E. Miliutina ◽  
M. Erzina ◽  
Y. Kalachyova ◽  
R. Elashnikov ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
High Sensitivity ◽  
Plasmonic Coupling ◽  
Sers Detection

Plasmonically active nanorods for delivery of bio-active agents and high-sensitivity SERS detection in planta

RSC Advances ◽  
2014 ◽  
Vol 4 (110) ◽  
pp. 64985-64993 ◽  
Author(s):  
Zeid A. Nima ◽  
Mohamed H. Lahiani ◽  
Fumiya Watanabe ◽  
Yang Xu ◽  
Mariya V. Khodakovskaya ◽  
...  
Keyword(s):  
High Sensitivity ◽  
In Planta ◽  
Sers Detection

Quantitative SERS Detection of Trace Glutathione with Internal Reference Embedded Au-core/Ag-shell Nanoparticles

Nano LIFE ◽  
2016 ◽  
Vol 06 (03n04) ◽  
pp. 1642003 ◽  
Author(s):  
Yan Zhou ◽  
Rui Ding
Keyword(s):  
Reference Method ◽  
High Sensitivity ◽  
Internal Reference ◽  
Shell Nanoparticles ◽  
New Strategy ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Quantitative Sers ◽  
Shell Particles ◽  
Improved Accuracy

Surface-enhanced Raman scattering (SERS) has been widely studied and applied for over three decades. However, reliable SERS detection of molecules with low polarizability is still suffering from poor sensitivity and reproducibility. In this paper, we have reported a new strategy for performing quantitative SERS detection of Raman insensitive Glutathione (GSH), based on GSH-induced replacement of a highly Raman sensitive four-mercaptopyridine (MP) adsorbed on the surface of four-aminothiophenol (ATP) embedded Au-core/Ag-shell particles. This replacement led to a strong decrease of the MP SERS signal, which was used to determine the concentration of GSH. The adoption of GSH-induced Raman probe replacement leads to high sensitivity, while the use of internal reference method provides an improved accuracy of the GSH quantification.

scholarly journals High Sensitivity, High Selectivity SERS Detection of MnSOD Using Optical Nanoantennas Functionalized with Aptamers

2015 ◽  
Vol 119 (27) ◽  
pp. 15532-15540 ◽  
Author(s):  
Maximilien Cottat ◽  
Cristiano D’Andrea ◽  
Ryohei Yasukuni ◽  
Natalia Malashikhina ◽  
Ruta Grinyte ◽  
...  
Keyword(s):  
High Selectivity ◽  
High Sensitivity ◽  
Sers Detection ◽  
Optical Nanoantennas

A porous Au–Ag hybrid nanoparticle array with broadband absorption and high-density hotspots for stable SERS analysis

Nanoscale ◽  
2019 ◽  
Vol 11 (19) ◽  
pp. 9587-9592 ◽  
Author(s):  
Kuanguo Li ◽  
Guangju Liu ◽  
Sheng Zhang ◽  
Yanqiu Dai ◽  
Sonia Ghafoor ◽  
...  
Keyword(s):  
Low Cost ◽  
High Sensitivity ◽  
High Density ◽  
Nanoparticle Array ◽  
Broadband Absorption ◽  
Sers Detection ◽  
Hybrid Nanoparticle

An Au–Ag hybrid nanoparticle array with dense hotspots was constructed through a low-cost route for SERS detection with high sensitivity and stability.

Multiplexed electrochemical and SERS dual-mode detection of stroke biomarkers: rapid screening with high sensitivity

2019 ◽  
Vol 43 (34) ◽  
pp. 13381-13387 ◽  
Author(s):  
Jingyi Sun ◽  
Yi Zhao ◽  
Yajun Hou ◽  
Hanxia Li ◽  
Mingfeng Yang ◽  
...  
Keyword(s):  
Neuron Specific Enolase ◽  
High Sensitivity ◽  
Rapid Screening ◽  
Label Free ◽  
Raman Spectroscopic ◽  
Mode Detection ◽  
Β Protein ◽  
Highly Sensitive ◽  
Surface Enhanced Raman ◽  
Sers Detection

In this work, a real-time assay for a highly sensitive, label-free, multiplexed electrochemical and surface-enhanced Raman spectroscopic (SERS) detection of stroke biomarkers by neuron-specific enolase (NSE) and S100-β protein was developed using lateral flow devices.

scholarly journals Optical Aggregation of Gold Nanoparticles for SERS Detection of Proteins and Toxins in Liquid Environment: Towards Ultrasensitive and Selective Detection

2018 ◽  
Author(s):  
Antonino Foti ◽  
Cristiano D'andrea ◽  
Valentina Villari ◽  
Norberto Micali ◽  
Maria Grazia Donato ◽  
...  
Keyword(s):  
Hot Spots ◽  
High Sensitivity ◽  
Quantitative Detection ◽  
Selective Detection ◽  
Liquid Environment ◽  
Fungal Toxin ◽  
First Results ◽  
Sers Detection ◽  
Molecular Specificity ◽  
Food Commodities

Optical forces are used to aggregate plasmonic nanoparticles and create SERS-active hot spots in liquid. When biomolecules are added to the nanoparticles, high sensitivity SERS detection is accomplished. Here we tailor this methodology to detect catalase and hemoglobin, two Raman resonant biomolecules, at concentrations down to 10 nM and 1 pM. Subsequently, we study the SERS signal in Bovine Serum Albumin as a function of the concentration, finding a monotonic dependence that suggests the possibility of quantitative detection. Finally, by exploiting nanoparticles functionalized with specific aptamers, we obtain first results on the SERS detection of Ochratoxin A, a fungal toxin found in food commodities and wine. This represents a first step towards the addition of molecular specificity to this novel biosensor strategy.

scholarly journals Multilayer Gold-Silver Bimetallic Nanostructures to Enhance SERS Detection of Drugs

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3405 ◽  
Author(s):  
Marta Gambucci ◽  
Elena Cambiotti ◽  
Paola Sassi ◽  
Loredana Latterini
Keyword(s):  
High Sensitivity ◽  
Accurate Information ◽  
Drug Detection ◽  
Drug Molecules ◽  
Gold Silver ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Molecular Specificity ◽  
Enhanced Raman Scattering ◽  
Bimetallic Nanostructures

Surface-enhanced Raman scattering (SERS) is a widely used technique for drug detection due to high sensitivity and molecular specificity. The applicability and selectivity of SERS in the detection of specific drug molecules can be improved by gathering information on the specific interactions occurring between the molecule and the metal surface. In this work, multilayer gold-silver bimetallic nanorods (Au@Ag@AuNRs) have been prepared and used as platforms for SERS detection of specific drugs (namely promethazine, piroxicam, furosemide and diclofenac). The analysis of SERS spectra provided accurate information on the molecular location upon binding and gave some insight into molecule-surface interactions and selectivity in drug detection through SERS.

scholarly journals SERS Immunosensor of Array Units Surrounded by Particles: A Platform for Auxiliary Diagnosis of Hepatocellular Carcinoma

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2090
Author(s):  
Mingyu Cheng ◽  
Yongjun Zhang ◽  
Yaxin Wang ◽  
Aonan Zhu ◽  
Lei Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Electric Fields ◽  
Hot Spot ◽  
High Sensitivity ◽  
Fdtd Simulation ◽  
Whole Process ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Enhanced Raman Scattering ◽  
Different Diameters

Hepatocellular carcinoma (HCC) is one of the diseases with high mortality worldwide, so its early diagnosis and treatment have attracted much attention. Due to the advantages of the high sensitivity of surface-enhanced Raman scattering (SERS) detection, SERS has excellent application value in the diagnosis of HCC. In this paper, silver nanoparticles (AgNPs) are modified by magnetron sputtering on the surface of polystyrene (PS) templates with spheres of two different diameters. The array of units surrounded by particles is successfully prepared and the SERS performance is characterized. The effect of the gap between AgNPs on plasmon coupling and hot spot distribution is discussed. Finite-difference time domain (FDTD) simulation is used to verify the electric fields and hot spot distribution of the array. The differences in the concentrations of HCC markers are analyzed by using the change of SERS signal intensity of the array. The whole process proves that the preparation of structures with a strong local electric field to provide highly sensitive SERS signals is a key link in the detection of HCC markers, which is conducive to the diagnosis of HCC and has potential application value in clinical diagnosis.

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