Advances in label-free optical biosensing: direct comparison of whispering gallery mode sensors with surface plasmon resonance

2008 ◽  
Author(s):  
A. François ◽  
S. Krishnamoorthy ◽  
M. Himmelhaus
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Whispering Gallery Mode ◽  
Label Free ◽  
Optical Biosensing ◽  
Whispering Gallery

scholarly journals Plasmonic Based Biosensors: The Future in Biomedical Applications (Preprint)

2020 ◽  
Author(s):  
Omar Cavazos ◽  
Maurizio Manzo
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Biomedical Applications ◽  
Whispering Gallery Mode ◽  
Review Article ◽  
Localized Surface Plasmon ◽  
Plasmonic Sensors ◽  
Whispering Gallery ◽  
Innovative Method

UNSTRUCTURED The use of plasmonic sensors has been an important innovative method for accomplishing various tasks. This review article discusses a broad scope of plasmonic sensors in bio-medical applications. Most of the devices and methods discussed are based on the surface plasmon resonance (SPR). However, other topics discussed include the localized surface plasmon resonance and the whispering gallery mode (WGM) phenomenon. This paper reviews a wide variety of contributions to biosensing.

scholarly journals Plasmonic and Hybrid Whispering Gallery Mode–Based Biosensors: Literature Review

10.2196/17781 ◽  
2021 ◽  
Vol 6 (2) ◽  
pp. e17781
Author(s):  
Maurizio Manzo ◽  
Omar Cavazos ◽  
Zhenhua Huang ◽  
Liping Cai
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Point Of Care ◽  
Whispering Gallery Mode ◽  
Simple Explanation ◽  
Plasmonic Sensors ◽  
Whispering Gallery ◽  
The Relationship ◽  
Biosensor Applications

Background The term “plasmonic” describes the relationship between electromagnetic fields and metallic nanostructures. Plasmon-based sensors have been used innovatively to accomplish different biomedical tasks, including detection of cancer. Plasmonic sensors also have been used in biochip applications and biosensors and have the potential to be implemented as implantable point-of-care devices. Many devices and methods discussed in the literature are based on surface plasmon resonance (SPR) and localized SPR (LSPR). However, the mathematical background can be overwhelming for researchers at times. Objective This review article discusses the theory of SPR, simplifying the underlying physics and bypassing many equations of SPR and LSPR. Moreover, we introduce and discuss the hybrid whispering gallery mode (WGM) sensing theory and its applications. Methods A literature search in ScienceDirect was performed using keywords such as “surface plasmon resonance,” “localized plasmon resonance,” and “whispering gallery mode/plasmonic.” The search results retrieved many articles, among which we selected only those that presented a simple explanation of the SPR phenomena with prominent biomedical examples. Results SPR, LSPR, tilted fiber Bragg grating, and hybrid WGM phenomena were explained and examples on biosensing applications were provided. Conclusions This minireview presents an overview of biosensor applications in the field of biomedicine and is intended for researchers interested in starting to work in this field. The review presents the fundamental notions of plasmonic sensors and hybrid WGM sensors, thereby allowing one to get familiar with the terminology and underlying complex formulations of linear and nonlinear optics.

Whispering gallery mode and surface plasmon resonance based refractometric sensors

2013 ◽  
Author(s):  
Kristopher J. Rowland ◽  
Alexandre François ◽  
Beniamino Sciacca ◽  
Tanya M. Monro
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Whispering Gallery Mode ◽  
Whispering Gallery

Plasma enhanced label-free immunoassay for alpha-fetoprotein based on a U-bend fiber-optic LSPR biosensor

RSC Advances ◽  
2015 ◽  
Vol 5 (31) ◽  
pp. 23990-23998 ◽  
Author(s):  
Gaoling Liang ◽  
Zhongjun Zhao ◽  
Yin Wei ◽  
Kunping Liu ◽  
Wenqian Hou ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Localized Surface Plasmon Resonance ◽  
Fiber Optic ◽  
Cost Effective ◽  
Alpha Fetoprotein ◽  
Localized Surface Plasmon ◽  
Label Free

A simple, label-free and cost-effective localized surface plasmon resonance (LSPR) immunosensing method was developed for detection of alpha-fetoprotein (AFP).

scholarly journals Modifications of the PAMONO-Sensor Help to Size and Quantify Low Number of Individual Biological and Non-Biological Nano-Particles

2021 ◽  
Vol 6 (1) ◽  
pp. 26
Author(s):  
Rahat Morad Talukder ◽  
Al Shahriar Hossain Rakib ◽  
Julija Skolnik ◽  
Zohair Usfoor ◽  
Katharina Kaufmann ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Nano Particles ◽  
Label Free ◽  
Specific Detection ◽  
Virus Like Particles ◽  
Low Concentrations ◽  
Challenging Tasks ◽  
Image Area

In a series of recently published works, we demonstrated that the plasmon-assisted microscopy of nano-objects (PAMONO) technique can be successfully employed for the sizing and quantification of single viruses, virus-like particles, microvesicles and charged non-biological particles. This approach enables label-free, but specific detection of biological nano-vesicles. Hence, the sensor, which was built up utilizing plasmon-assisted microscopy, possesses relative versatility and it can be used as a platform for cell-based assays. However, one of the challenging tasks for such a sensor was the ability to reach a homogeneous illumination of the whole surface of the gold sensor slide. Moreover, in order to enable the detection of even relatively low concentrations of nano-particles, the focused image area had to be expanded. Both tasks were solved via modifications of previously described PAMONO-sensor set ups. Taken together, our latest findings can help to develop a research and diagnostic platform based on the principles of the surface plasmon resonance (SPR)-assisted microscopy of nano-objects.

scholarly journals Trends in SPR Cytometry: Advances in Label-Free Detection of Cell Parameters

Biosensors ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 102 ◽  
Author(s):  
Richard Schasfoort ◽  
Fikri Abali ◽  
Ivan Stojanovic ◽  
Gestur Vidarsson ◽  
Leon Terstappen
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Mammalian Cells ◽  
Living Cells ◽  
Label Free ◽  
Intact Cells ◽  
Cell Parameters ◽  
Spr Imaging ◽  
Label Free Detection

SPR cytometry entails the measurement of parameters from intact cells using the surface plasmon resonance (SPR) phenomenon. Specific real-time and label-free binding of living cells to sensor surfaces has been made possible through the availability of SPR imaging (SPRi) instruments and researchers have started to explore its potential in the last decade. Here we will discuss the mechanisms of detection and additionally describe the problems and issues of mammalian cells in SPR biosensing, both from our own experience and with information from the literature. Finally, we build on the knowledge and applications that has already materialized in this field to give a forecast of some exciting applications for SPRi cytometry.

scholarly journals Rapid Antibody Selection Using Surface Plasmon Resonance for High-Speed and Sensitive Hazelnut Lateral Flow Prototypes

Biosensors ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 130 ◽  
Author(s):  
Georgina Ross ◽  
Maria Bremer ◽  
Jan Wichers ◽  
Aart van Amerongen ◽  
Michel Nielen
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
High Speed ◽  
Selection Process ◽  
Low Cost ◽  
Real Life ◽  
Cross Reactivity ◽  
Lateral Flow ◽  
Label Free

Lateral Flow Immunoassays (LFIAs) allow for rapid, low-cost, screening of many biomolecules such as food allergens. Despite being classified as rapid tests, many LFIAs take 10–20 min to complete. For a really high-speed LFIA, it is necessary to assess antibody association kinetics. By using a label-free optical technique such as Surface Plasmon Resonance (SPR), it is possible to screen crude monoclonal antibody (mAb) preparations for their association rates against a target. Herein, we describe an SPR-based method for screening and selecting crude anti-hazelnut antibodies based on their relative association rates, cross reactivity and sandwich pairing capabilities, for subsequent application in a rapid ligand binding assay. Thanks to the SPR selection process, only the fast mAb (F-50-6B12) and the slow (S-50-5H9) mAb needed purification for labelling with carbon nanoparticles to exploit high-speed LFIA prototypes. The kinetics observed in SPR were reflected in LFIA, with the test line appearing within 30 s, almost two times faster when F-50-6B12 was used, compared with S-50-5H9. Additionally, the LFIAs have demonstrated their future applicability to real life samples by detecting hazelnut in the sub-ppm range in a cookie matrix. Finally, these LFIAs not only provide a qualitative result when read visually, but also generate semi-quantitative data when exploiting freely downloadable smartphone apps.

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