Identification of stepped changes of binding affinity during interactions between the disintegrin rhodostomin and integrin α IIb β 3 in living cells using optical tweezers

2004 ◽  
Author(s):  
Chia-Fen Hsieh ◽  
Bo-Jui Chang ◽  
Chyi-Huey Pai ◽  
Hsuan-Yi Chen ◽  
Sien Chi ◽  
...  
Author(s):  
S. Suresh ◽  
C. T. Lim ◽  
M. Dao

The chemical and biological functions of living cells are known to be influenced strongly by mechanical forces and deformation, and the ability of cells to detect and support forces, in turn, is also affected by chemical and biological factors. Furthermore, the progression of a number of inherited and infectious diseases have also been identified to have a strong correlation with the mechanical deformation characteristics of biological cells. Consequently, the deformation characteristics of whole cells and cell membranes have long been investigated using a variety of experimental methods, such as the micropipette aspiration technique, and by computational modeling (see, for example, refs. [1, 2]). Recent advances in experimental techniques capable of probing mechanical forces and displacements to a resolution of picoNewton and nanometer, respectively, have facilitated use of mechanical test methods for living cells whereby precise measurements of response under different stress states could be investigated.


2013 ◽  
Vol 11 (9) ◽  
pp. 091701-91704 ◽  
Author(s):  
Jie Yu Jie Yu ◽  
Xunliang Tong Xunliang Tong ◽  
Chengbin Li Chengbin Li ◽  
Yining Huang Yining Huang ◽  
Anpei Ye Anpei Ye

2008 ◽  
Vol 112 (9) ◽  
pp. 2734-2737 ◽  
Author(s):  
Patricia M. A. Farias ◽  
Beate S. Santos ◽  
André A. de Thomaz ◽  
Ricardo Ferreira ◽  
Frederico D. Menezes ◽  
...  

2006 ◽  
Author(s):  
Valentina Emiliani ◽  
Daniele Sanvitto ◽  
Christiane Durieux

2018 ◽  
Vol 427 ◽  
pp. 563-566 ◽  
Author(s):  
Yu Zhang ◽  
Yan Li ◽  
Yaxun Zhang ◽  
Chuanzhen Hu ◽  
Zhihai Liu ◽  
...  

Author(s):  
Carolin Riesenberg ◽  
Christian Alejandro Iriarte-Valdez ◽  
Annegret Becker ◽  
Maria Dienerowitz ◽  
Alexander Heisterkamp ◽  
...  

2012 ◽  
Author(s):  
Inna V. Il'ina ◽  
Dmitry S. Sitnikov ◽  
Andrey V. Ovchinnikov ◽  
Mikhail B. Agranat ◽  
Yulia V. Khramova ◽  
...  

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