Histopathologic assessment of water-dominated photothermal effects produced with laser irradiation

1991 ◽  
Author(s):  
Sharon L. Thomsen ◽  
Wai-Fung Cheong ◽  
John A. Pearce
Keyword(s):  
Laser Irradiation ◽  
Photothermal Effects

An approach of bubble generation and manipulation by using the photothermal effects of laser irradiation on light absorbing particles

2021 ◽  
Vol 92 (11) ◽  
pp. 114902
Author(s):  
Bo-Wei Li ◽  
Jia-Wen He ◽  
Wen Bai ◽  
Hao-Dong Wang ◽  
Feng Ji ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Bubble Generation ◽  
Photothermal Effects

Photothermal effects and toxicity of Fe3O4 nanoparticles via near infrared laser irradiation for cancer therapy

2015 ◽  
Vol 46 ◽  
pp. 97-102 ◽  
Author(s):  
Andrew W. Dunn ◽  
Sadat M. Ehsan ◽  
David Mast ◽  
Giovanni M. Pauletti ◽  
Hong Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Laser Irradiation ◽  
Fe3o4 Nanoparticles ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation ◽  
Photothermal Effects

Magnetic resonance thermometry for monitoring photothermal effects of interstitial laser irradiation

2012 ◽  
Author(s):  
Jessica Goddard ◽  
Jessnie Jose ◽  
Daniel Figueroa ◽  
Kelvin Le ◽  
Hong Liu ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Laser Irradiation ◽  
Magnetic Resonance Thermometry ◽  
Interstitial Laser ◽  
Photothermal Effects

Ultrasmall Gold Nanoparticles Anchored to Graphene and Enhanced Photothermal Effects by Laser Irradiation of Gold Nanostructures in Graphene Oxide Solutions

ACS Nano ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. 627-636 ◽  
Author(s):  
Abdallah F. Zedan ◽  
Sherif Moussa ◽  
James Terner ◽  
Garrett Atkinson ◽  
M. Samy El-Shall
Keyword(s):  
Gold Nanoparticles ◽  
Graphene Oxide ◽  
Laser Irradiation ◽  
Gold Nanostructures ◽  
Photothermal Effects

scholarly journals Chemo-photothermal effects of doxorubicin/silica–carbon hollow spheres on liver cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (64) ◽  
pp. 36775-36784 ◽  
Author(s):  
Ying-Chi Chen ◽  
Wen-Tai Chiu ◽  
Chin Chang ◽  
Ping-Ching Wu ◽  
Ting-Yuan Tu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Hollow Spheres ◽  
Liver Cancer Cells ◽  
Photothermal Effects ◽  
Carbon Hollow Spheres ◽  
Nir Laser

SCHSs were applied as vectors for drug delivery and thermal production under NIR laser irradiation. DOX-loaded SCHSs conjugated with ConA were found to kill liver cancer cells efficiently.

scholarly journals Photothermally Triggered Endosomal Escape and Its Influence on Transfection Efficiency of Gold-Functionalized JetPEI/pDNA Nanoparticles

2018 ◽  
Vol 19 (8) ◽  
pp. 2400 ◽  
Author(s):  
Lotte Vermeulen ◽  
Juan Fraire ◽  
Laurens Raes ◽  
Ellen De Meester ◽  
Sarah De Keulenaer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Laser Irradiation ◽  
Laser Energy ◽  
Transfection Efficiency ◽  
Laser Pulses ◽  
High Energy ◽  
Endosomal Escape ◽  
Localized Surface Plasmon ◽  
Endosomal Membrane ◽  
Photothermal Effects

Plasmonic nanoparticles for drug delivery have attracted increasing interest over the last few years. Their localized surface plasmon resonance causes photothermal effects on laser irradiation, which allows for delivering drugs in a spatio-temporally controlled manner. Here, we explore the use of gold nanoparticles (AuNP) as carriers for pDNA in combination with pulsed laser irradiation to induce endosomal escape, which is currently considered to be one of the major bottlenecks in macromolecular drug delivery on the intracellular level. In particular, we evaluate nanocomplexes composed of JetPEI (polyethylenimine)pDNA and 10 nm AuNP, which do not exhibit endosomal escape by themselves. After incubating HeLa cells with these complexes, we evaluated endosomal escape and transfection efficiency using low- and high-energy laser pulses. At low laser energy heat is produced by the nanocomplexes, while, at higher laser energy, explosive vapour nanobubbles (VNB) are formed. We investigated the ability of heat transfer and VNB formation to induce endosomal escape and we examine the integrity of pDNA cargo after inducing both photothermal effects. We conclude that JetPEI/pDNA/AuNP complexes are unable to induce meaningful transfection efficiencies because laser treatment causes either dysfunctionality of the cargo when VNB are formed or forms too small pores in the endosomal membrane to allow pDNA to escape in case of heating. We conclude that laser-induced VNB is the most suitable to induce effective pDNA endosomal escape, but a different nanocomplex structure will be required to keep the pDNA intact.

Chronic Laser Exposure Effects on Rabbit Retina

1972 ◽  
Vol 30 ◽  
pp. 54-55
Author(s):  
Burton B. Silver ◽  
Theodore Lawwill
Keyword(s):  
Laser Irradiation ◽  
Laser Light ◽  
Broad Band ◽  
Argon Laser ◽  
Atropine Sulfate ◽  
Ultrastructural Changes ◽  
Laser Exposure ◽  
Rabbit Retina ◽  
Histological Changes ◽  
Threshold Doses

Dutch-belted 1 to 2.5 kg anesthetized rabbits were exposed to either xenon or argon laser light administered in a broad band, designed to cover large areas of the retina. For laser exposure, the pupil was dilated with atropine sulfate 1% and pheny lephrine 10%. All of the laser generated power was within a band centered at 5145.0 Anstroms. Established threshold for 4 hour exposures to laser irradiation are in the order of 25-35 microwatts/cm2. Animals examined for ultrastructural changes received 4 hour threshold doses. These animals exhibited ERG, opthalmascopic, and histological changes consistent with threshold damage.One month following exposure the rabbits were killed with pentobarbitol. The eyes were immediately enucleated and dissected while bathed in 3% phosphate buffered gluteraldehyde.

Microstructural changes of Aluminum Nitride after laser irradiation and electroless copper deposition

1994 ◽  
Vol 52 ◽  
pp. 636-637
Author(s):  
S. Cao ◽  
A. J. Pedraza ◽  
L. F. Allard
Keyword(s):  
Aluminum Nitride ◽  
Laser Irradiation ◽  
Electroless Deposition ◽  
Thermal Evaporation ◽  
Surface Region ◽  
Near Surface ◽  
Laser Patterning ◽  
Electroless Copper ◽  
Excimer Laser Irradiation ◽  
Laser Effect

Excimer-laser irradiation strongly modifies the near-surface region of aluminum nitride (AIN) substrates. The surface acquires a distinctive metallic appearance and the electrical resistivity of the near-surface region drastically decreases after laser irradiation. These results indicate that Al forms at the surface as a result of the decomposition of the Al (which has been confirmed by XPS). A computer model that incorporates two opposing phenomena, decomposition of the AIN that leaves a metallic Al film on the surface, and thermal evaporation of the Al, demonstrated that saturation of film thickness and, hence, of electrical resistance is reached when the rate of Al evaporation equals the rate of AIN decomposition. In an electroless copper bath, Cu is only deposited in laser-irradiated areas. This laser effect has been designated laser activation for electroless deposition. Laser activation eliminates the need of seeding for nucleating the initial layer of electroless Cu. Thus, AIN metallization can be achieved by laser patterning followed by electroless deposition.

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