An approach of bubble generation and manipulation by using the photothermal effects of laser irradiation on light absorbing particles

2021 ◽  
Vol 92 (11) ◽  
pp. 114902
Author(s):  
Bo-Wei Li ◽  
Jia-Wen He ◽  
Wen Bai ◽  
Hao-Dong Wang ◽  
Feng Ji ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Bubble Generation ◽  
Photothermal Effects

Photothermal effects and toxicity of Fe3O4 nanoparticles via near infrared laser irradiation for cancer therapy

2015 ◽  
Vol 46 ◽  
pp. 97-102 ◽  
Author(s):  
Andrew W. Dunn ◽  
Sadat M. Ehsan ◽  
David Mast ◽  
Giovanni M. Pauletti ◽  
Hong Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Laser Irradiation ◽  
Fe3o4 Nanoparticles ◽  
Near Infrared ◽  
Infrared Laser ◽  
Infrared Laser Irradiation ◽  
Photothermal Effects

Magnetic resonance thermometry for monitoring photothermal effects of interstitial laser irradiation

2012 ◽  
Author(s):  
Jessica Goddard ◽  
Jessnie Jose ◽  
Daniel Figueroa ◽  
Kelvin Le ◽  
Hong Liu ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Laser Irradiation ◽  
Magnetic Resonance Thermometry ◽  
Interstitial Laser ◽  
Photothermal Effects

Ultrasmall Gold Nanoparticles Anchored to Graphene and Enhanced Photothermal Effects by Laser Irradiation of Gold Nanostructures in Graphene Oxide Solutions

ACS Nano ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. 627-636 ◽  
Author(s):  
Abdallah F. Zedan ◽  
Sherif Moussa ◽  
James Terner ◽  
Garrett Atkinson ◽  
M. Samy El-Shall
Keyword(s):  
Gold Nanoparticles ◽  
Graphene Oxide ◽  
Laser Irradiation ◽  
Gold Nanostructures ◽  
Photothermal Effects

scholarly journals Photomechanical Polymer Nanocomposites for Drug Delivery Devices

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5376
Author(s):  
Jonathan David López-Lugo ◽  
Reinher Pimentel-Domínguez ◽  
Jorge Alejandro Benítez-Martínez ◽  
Juan Hernández-Cordero ◽  
Juan Rodrigo Vélez-Cordero ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Numerical Simulations ◽  
Laser Irradiation ◽  
Polymer Nanocomposites ◽  
Rhodamine B ◽  
Carbon Nanoparticles ◽  
Bubble Generation ◽  
Carbon Nanocomposites ◽  
Novel Structure ◽  
Drug Delivery Devices

We demonstrate a novel structure based on smart carbon nanocomposites intended for fabricating laser-triggered drug delivery devices (DDDs). The performance of the devices relies on nanocomposites’ photothermal effects that are based on polydimethylsiloxane (PDMS) with carbon nanoparticles (CNPs). Upon evaluating the main features of the nanocomposites through physicochemical and photomechanical characterizations, we identified the main photomechanical features to be considered for selecting a nanocomposite for the DDDs. The capabilities of the PDMS/CNPs prototypes for drug delivery were tested using rhodamine-B (Rh-B) as a marker solution, allowing for visualizing and quantifying the release of the marker contained within the device. Our results showed that the DDDs readily expel the Rh-B from the reservoir upon laser irradiation and the amount of released Rh-B depends on the exposure time. Additionally, we identified two main Rh-B release mechanisms, the first one is based on the device elastic deformation and the second one is based on bubble generation and its expansion into the device. Both mechanisms were further elucidated through numerical simulations and compared with the experimental results. These promising results demonstrate that an inexpensive nanocomposite such as PDMS/CNPs can serve as a foundation for novel DDDs with spatial and temporal release control through laser irradiation.

scholarly journals Chemo-photothermal effects of doxorubicin/silica–carbon hollow spheres on liver cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (64) ◽  
pp. 36775-36784 ◽  
Author(s):  
Ying-Chi Chen ◽  
Wen-Tai Chiu ◽  
Chin Chang ◽  
Ping-Ching Wu ◽  
Ting-Yuan Tu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Hollow Spheres ◽  
Liver Cancer Cells ◽  
Photothermal Effects ◽  
Carbon Hollow Spheres ◽  
Nir Laser

SCHSs were applied as vectors for drug delivery and thermal production under NIR laser irradiation. DOX-loaded SCHSs conjugated with ConA were found to kill liver cancer cells efficiently.

scholarly journals Photothermally Triggered Endosomal Escape and Its Influence on Transfection Efficiency of Gold-Functionalized JetPEI/pDNA Nanoparticles

2018 ◽  
Vol 19 (8) ◽  
pp. 2400 ◽  
Author(s):  
Lotte Vermeulen ◽  
Juan Fraire ◽  
Laurens Raes ◽  
Ellen De Meester ◽  
Sarah De Keulenaer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Laser Irradiation ◽  
Laser Energy ◽  
Transfection Efficiency ◽  
Laser Pulses ◽  
High Energy ◽  
Endosomal Escape ◽  
Localized Surface Plasmon ◽  
Endosomal Membrane ◽  
Photothermal Effects

Plasmonic nanoparticles for drug delivery have attracted increasing interest over the last few years. Their localized surface plasmon resonance causes photothermal effects on laser irradiation, which allows for delivering drugs in a spatio-temporally controlled manner. Here, we explore the use of gold nanoparticles (AuNP) as carriers for pDNA in combination with pulsed laser irradiation to induce endosomal escape, which is currently considered to be one of the major bottlenecks in macromolecular drug delivery on the intracellular level. In particular, we evaluate nanocomplexes composed of JetPEI (polyethylenimine)pDNA and 10 nm AuNP, which do not exhibit endosomal escape by themselves. After incubating HeLa cells with these complexes, we evaluated endosomal escape and transfection efficiency using low- and high-energy laser pulses. At low laser energy heat is produced by the nanocomplexes, while, at higher laser energy, explosive vapour nanobubbles (VNB) are formed. We investigated the ability of heat transfer and VNB formation to induce endosomal escape and we examine the integrity of pDNA cargo after inducing both photothermal effects. We conclude that JetPEI/pDNA/AuNP complexes are unable to induce meaningful transfection efficiencies because laser treatment causes either dysfunctionality of the cargo when VNB are formed or forms too small pores in the endosomal membrane to allow pDNA to escape in case of heating. We conclude that laser-induced VNB is the most suitable to induce effective pDNA endosomal escape, but a different nanocomplex structure will be required to keep the pDNA intact.

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