scholarly journals Chemo-photothermal effects of doxorubicin/silica–carbon hollow spheres on liver cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (64) ◽  
pp. 36775-36784 ◽  
Author(s):  
Ying-Chi Chen ◽  
Wen-Tai Chiu ◽  
Chin Chang ◽  
Ping-Ching Wu ◽  
Ting-Yuan Tu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Hollow Spheres ◽  
Liver Cancer Cells ◽  
Photothermal Effects ◽  
Carbon Hollow Spheres ◽  
Nir Laser

SCHSs were applied as vectors for drug delivery and thermal production under NIR laser irradiation. DOX-loaded SCHSs conjugated with ConA were found to kill liver cancer cells efficiently.

The photothermal effect of silica–carbon hollow sphere–concanavalin A on liver cancer cells

2015 ◽  
Vol 3 (12) ◽  
pp. 2447-2454 ◽  
Author(s):  
Ying-Chi Chen ◽  
Wen-Tai Chiu ◽  
Jung-Chih Chen ◽  
Chia-Sheng Chang ◽  
Lily Hui-Ching Wang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cell Surface ◽  
Cancer Cells ◽  
Laser Irradiation ◽  
Concanavalin A ◽  
Hollow Sphere ◽  
Hollow Spheres ◽  
Photothermal Effect ◽  
Liver Cancer Cells ◽  
Nir Laser

We used silica–carbon hollow spheres (SCHSs) as material for thermal production under NIR laser irradiation. Concanavalin A (ConA), a lectin, was applied to enhance binding on the cell surface of liver cancer cells. We demonstrated that ConA conjugated SCHSs killed liver cancer cells efficiently.

In vitro study of doxorubicin-loaded thermo- and pH-tunable carriers for targeted drug delivery to liver cancer cells

2021 ◽  
Vol 104 ◽  
pp. 93-105
Author(s):  
Sikhumbuzo Charles Kunene ◽  
Kuen-Song Lin ◽  
Meng-Tzu Weng ◽  
Maria Janina Carrera Espinoza ◽  
Chun-Ming Wu
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Liver Cancer Cells ◽  
Targeted Drug

Drug delivery of pH-Sensitive Nanoparticles into the liver cancer cells

2021 ◽  
pp. 102557
Author(s):  
Maryam Saadat ◽  
Farid Mostafaei ◽  
Somaye Mahdinloo ◽  
Mahdieh Abdi ◽  
Fahimeh Zahednezhad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Ph Sensitive ◽  
Liver Cancer Cells

Panobinostat treatment determines oncogenic miRNAs down-regulation in liver cancer cells

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
A Henrici ◽  
R Montalbano ◽  
K Quint ◽  
M Ocker ◽  
P Di Fazio
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Down Regulation ◽  
Liver Cancer Cells ◽  
Oncogenic Mirnas

HBV-Encoded miR-2 Functions as an Oncogene by Downregulating TRIM35 But Upregulating RAN in Liver Cancer Cells

2019 ◽  
Author(s):  
Lili Yao ◽  
Zhen-hua Sui ◽  
Yan-Kun Liu ◽  
Hong Xie ◽  
Hui-jie Gao ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells

Titanium Oxide Nanoparticles Improve the Chemotherapeutic Action of Erlotinib in Liver Cancer Cells

2020 ◽  
Vol 16 (4) ◽  
pp. 337-343
Author(s):  
Shaimaa E. Abdel-Ghany ◽  
Eman El-Sayed ◽  
Nour Ashraf ◽  
Nada Mokhtar ◽  
Amany Alqosaibi ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Titanium Oxide ◽  
Phase Distribution ◽  
Oxide Nanoparticles ◽  
Titanium Oxide Nanoparticles ◽  
Liver Cancer Cells ◽  
M Phase ◽  
Apoptosis Detection ◽  
Novel Method

Background: Hepatocellular carcinoma is the second leading cause of cancer-related deaths among other types of cancer due to lack of effective treatments and late diagnosis. Nanocarriers represent a novel method to deliver chemotherapeutic drugs, enhancing their bioavailability and stability. Methods: In the present study, we loaded gold nanoparticles (AuNPs) and titanium oxide nanoparticles (TiO2NPs) with ERL to investigate the efficiency of the formed composite in inducing apoptosis in HepG2 liver cancer cells. Cytotoxicity was assessed using MTT assay and cell phase distribution was assessed by flow cytometry along with apoptosis detection. Results: Data obtained indicated the efficiency of the formed composite to significantly induce cell death and arrest cell cycle and G2/M phase. IRF4 was downregulated after treatment with loaded ERL. Conclusion: Our data showed that loading ERL on TiO2NPs was more efficient than AuNPs. However, both nanocarriers were efficient compared with control.

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