Investigations of normal skin tissue using fiber optical FTIR spectroscopy

1998 ◽  
Author(s):  
Angelique L. Brooks ◽  
Reinhard F. Bruch ◽  
Natalia I. Afanasyeva ◽  
Sergei F. Kolyakov ◽  
Leonid N. Butvina ◽  
...  
Keyword(s):  
Ftir Spectroscopy ◽  
Normal Skin ◽  
Skin Tissue ◽  
Fiber Optical

MicroRNA Profile Differentiates Head and Neck Keloid and Adjacent Normal Skin Tissue

2021 ◽  
Author(s):  
Lamont R. Jones ◽  
Albert M. Levin ◽  
Xiangguo Dai ◽  
Indrani Datta ◽  
Jia Li ◽  
...  
Keyword(s):  
Head And Neck ◽  
Normal Skin ◽  
Skin Tissue ◽  
Microrna Profile

scholarly journals Basophil Recruitment to Skin Lesions of Patients with Systemic Lupus Erythematosus Mediated by CCR1 and CCR2

2017 ◽  
Vol 43 (2) ◽  
pp. 832-839 ◽  
Author(s):  
Qingjun Pan ◽  
Yongmin Feng ◽  
Yanxia Peng ◽  
Hongjiu Zhou ◽  
Zhenzhen Deng ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Migration Rate ◽  
Skin Diseases ◽  
Normal Skin ◽  
Flow Cytometric Analysis ◽  
Skin Lesions ◽  
Skin Tissue ◽  
Systemic Lupus

Background/Aims: Basophils have been reported to infiltrate skin lesions in various skin diseases, but not in systemic lupus erythematosus (SLE). This study investigated basophil infiltration in SLE and its mechanism. Methods: Twenty newly diagnosed SLE patients and twenty healthy controls were enrolled. Nine SLE patients underwent skin biopsies. Flow cytometric analysis the phenotype of peripheral basophils and their migration rate toward RANTES and MCP-1 were analyzed with the transwell culture system, also the expression of these two chemokines in skin tissue were analyzed with immunohistochemistry. Results: Increased activation and decreased numbers of peripheral basophils were observed in SLE patients compared with controls. Basophil migration into skin lesions of SLE patients were observed, but not in normal skin tissue. This migration was related to the upregulation of chemokine receptors CCR1 and CCR2 on basophils. In vitro studies showed that migration rate toward RANTES and MCP-1 increased significantly in basophils from SLE patients compared with those from controls. Consistently, high levels of RANTES and MCP-1 expression were observed in skin lesions from SLE patients but not in normal skin tissue. Conclusion: Basophil recruitment to skin lesions of SLE patients mediated by CCR1 and CCR2, which may contribute to tissue damage in SLE.

scholarly journals LncRNA expression profiles and validation in keloid and normal skin tissue

2015 ◽  
Vol 47 (5) ◽  
pp. 1829-1838 ◽  
Author(s):  
XUEBING LIANG ◽  
LIN MA ◽  
XIAO LONG ◽  
XIAOJUN WANG
Keyword(s):  
Expression Profiles ◽  
Normal Skin ◽  
Skin Tissue ◽  
Lncrna Expression

scholarly journals LEPROMIN-LIKE ACTIVITY OF NORMAL SKIN TISSUE

1958 ◽  
Vol 29 (4) ◽  
Author(s):  
T. F. DAVEY ◽  
S. E. DREWETT
Keyword(s):  
Normal Skin ◽  
Skin Tissue

FEW-FTIR spectroscopy applications and computer data processing for noninvasive skin tissue diagnostics in vivo

1999 ◽  
Author(s):  
Angelique L. Brooks ◽  
Natalia I. Afanasyeva ◽  
Volodymyr Makhine ◽  
Reinhard F. Bruch ◽  
Byron McGregor
Keyword(s):  
Data Processing ◽  
Ftir Spectroscopy ◽  
Skin Tissue ◽  
Computer Data ◽  
Computer Data Processing ◽  
Tissue Diagnostics

DIABETIC INTERSTITIAL GLUCOSE IN THE SKIN TISSUE BY ATR-FTIR SPECTROSCOPY VERSUS CAPILLARY BLOOD GLUCOSE

2010 ◽  
Vol 03 (02) ◽  
pp. 81-90
Author(s):  
NATALJA SKREBOVA EIKJE
Keyword(s):  
Blood Glucose ◽  
Glucose Metabolism ◽  
Ftir Spectroscopy ◽  
Continuous Monitoring ◽  
Skin Tissue ◽  
Promising Alternative ◽  
Glucose Levels ◽  
Patients With Diabetes ◽  
Interstitial Glucose

Recently introduced horizontal attenuated total reflectance (HATR) Fourier transform infrared (FTIR) spectroscopy for real-time assessment and continuous monitoring of glucose biomolecules in the skin tissue directly on the patients might appear a promising alternative to interpret the activity of interstitial glucose metabolism in vivo by means of evaluating the dynamics of changes of glucose concentrations in interstitial fluid (IF). In the present study, in vivo spectra by ATR-FTIR spectroscopy were obtained post-prandially during a 120–180-minute continuous monitoring in three patients with type 2 diabetes and compared to pre-prandial spectra. In all patients with diabetes interstitial glucose levels at 1030 and 1041 cm-1 reflected the best relationship with blood glucose. The lag time (LT) required for glucose to diffuse from the capillary to epidermal skin tissue was calculated between 0 and 60 minutes at all measured glucose biomolecules. Data showed intra- and inter-subject variations of each glucose biomolecule, pointing to similarities and differences among interstitial glucose metabolism of the patients. Finally, the findings suggest that HATR-FTIR spectroscopy might have the potential for clinical interpretation of activity of glucose metabolism for diagnosis, management, and treatment of patients with diabetes.

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