Comparison of collagen orientation and distribution in-vivo between non-pregnant and pregnant human cervix using Mueller Matrix polarimetry (Conference Presentation)

2018 ◽  
Author(s):  
Joseph Chue-Sang ◽  
Mariacarla Gonzalez ◽  
Nola A. Holness ◽  
Ilyas Saytashev ◽  
Amir Gandjbakhche ◽  
...  
Keyword(s):  
Mueller Matrix ◽  
Collagen Orientation ◽  
Human Cervix

A comparison of the in vivo and in vitro radiation response of three human cervix carcinomas

1989 ◽  
Vol 16 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Lloyd R. Kelland ◽  
Katia S. Tonkin ◽  
G.Gordon Steel
Keyword(s):  
Radiation Response ◽  
Human Cervix

scholarly journals Mueller Matrix-Based Approach for the Ex Vivo Detection of Riboflavin-Treated Transparent Biotissue

2021 ◽  
Vol 11 (23) ◽  
pp. 11515
Author(s):  
Lennart Jütte ◽  
Gaurav Sharma ◽  
Dierk Fricke ◽  
Maximilian Franke ◽  
Merve Wollweber ◽  
...  
Keyword(s):  
Mechanical Stability ◽  
Ex Vivo ◽  
Measurement Data ◽  
Mueller Matrix ◽  
Cross Linking ◽  
Sample Number ◽  
Non Invasive ◽  
Collagen Cross Linking ◽  
Corneal Collagen

Corneal collagen cross-linking is an established procedure for the treatment of certain eye diseases which is applied to enhance the mechanical stability of such biotissue without deteriorating its functionality. However, being transparent, the optical analysis of the outcome of such treatments is cumbersome and relies on relatively expensive experimental equipment. We aim to apply the Mueller matrix polarimetry for the detection of photo-induced collagen cross-linking in transparent biotissue after treatment with riboflavin and UV irradiation. A simple Mueller matrix polarimetry setup could provide a fast and non-invasive analysis of transparent media to sensitively detect small photo-induced cross-linking effects in biotissue. We demonstrated the current capabilities of the approach on non-planar porcine cornea samples ex vivo. We reported the distinction between untreated and riboflavin-treated samples. The differences observed were correlated with the variation of certain Mueller matrix elements and parameters derived from the decomposition. The measurement data show variation in the cross-linked and non-cross-linked samples, although the effect of the UV treatment on the riboflavin-treated samples was not at the same level of significance yet and needs further investigation. The Mueller matrix measurement represents a promising approach for the detection of the effects of corneal collagen cross-linking. Further studies with a larger sample number are required to validate this approach. In the future, this could enable the reliable and non-invasive detection of photo-induced effects in biotissue and open the possibility for in vivo application, e.g., in eye disease treatment or the detection of scar collagen development.

Quantitative assessment of human cervix with correlation length ratio during pregnancy: An in vivo longitudinal study

2020 ◽  
Vol 148 (4) ◽  
pp. 2558-2558
Author(s):  
Mohammadreza Kari ◽  
Lindsey C. Carlson ◽  
Helen Feltovich ◽  
Timothy J. Hall
Keyword(s):  
Longitudinal Study ◽  
Correlation Length ◽  
Quantitative Assessment ◽  
Length Ratio ◽  
Human Cervix

Optical characterization of murine model's in-vivo skin using Mueller matrix polarimetric imaging

2015 ◽  
Author(s):  
Azael Mora-Núñez ◽  
Geminiano Martinez-Ponce ◽  
Guillermo Garcia-Torales
Keyword(s):  
Optical Characterization ◽  
Mueller Matrix ◽  
Polarimetric Imaging

scholarly journals Mueller matrix imaging for collagen scoring in mice model of pregnancy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hee Ryung Lee ◽  
Ilyas Saytashev ◽  
Vinh Nguyen Du Le ◽  
Mala Mahendroo ◽  
Jessica Ramella-Roman ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Preterm Birth ◽  
Second Harmonic ◽  
Mueller Matrix ◽  
Collagen Fibers ◽  
Optical Observations ◽  
Cervical Tissue ◽  
Mice Model ◽  
In Pregnancy

AbstractPreterm birth risk is associated with early softening of the uterine cervix in pregnancy due to the accelerated remodeling of collagen extracellular matrix. Studies of mice model of pregnancy were performed with an imaging Mueller polarimeter at different time points of pregnancy to find polarimetric parameters for collagen scoring. Mueller matrix images of the unstained sections of mice uterine cervices were taken at day 6 and day 18 of 19-days gestation period and at different spatial locations through the cervices. The logarithmic decomposition of the recorded Mueller matrices mapped the depolarization, linear retardance, and azimuth of the optical axis of cervical tissue. These images highlighted both the inner structure of cervix and the arrangement of cervical collagen fibers confirmed by the second harmonic generation microscopy. The statistical analysis and two-Gaussians fit of the distributions of linear retardance and linear depolarization in the entire images of cervical tissue (without manual selection of the specific regions of interest) quantified the randomization of collagen fibers alignment with gestation time. At day 18 the remodeling of cervical extracellular matrix of collagen was measurable at the external cervical os that is available for the direct optical observations in vivo. It supports the assumption that imaging Mueller polarimetry holds promise for the fast and accurate collagen scoring in pregnancy and the assessment of the preterm birth risk.

The Transient Response of a Collagen Remodeling Theory Based on Strain-Dependent Collagen Degradation

2012 ◽  
Author(s):  
A. Cilingir ◽  
W. Wilson ◽  
K. Ito ◽  
C. C. van Donkelaar
Keyword(s):  
Transient Response ◽  
Collagen Degradation ◽  
Mechanical Stimuli ◽  
Loading Conditions ◽  
Collagen Orientation ◽  
Collagen Remodeling ◽  
Engineered Tissues ◽  
Strain Dependent

In vivo [1] and in vitro [2–4] studies show that cell and matrix alignment can be significantly affected by mechanical stimuli. Even in highly aligned engineered tissues, cells are able to remodel the collagen orientation when loading conditions are altered [4].

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