Traumatic brain injury may occur in baseball due to a head impact with a thrown, pitched, or batted ball. It has been shown that the average pitching speed of youth pitchers and high school pitchers is approximately 63 mph (28 m/s) and 74 mph (33 m/s), respectively. At pitching speeds of approximately 52 mph (23 m/s), the bat exit velocity (BEV) for metal bats has been shown to be approximately 100 mph (45 m/s). Head kinematics, such as linear and angular head accelerations, are often used to establish head injury risk for head impacts. With a possible ball impact velocity reaching speeds in excess of those typically tested for baseball headgear, it is necessary to understand how the head will respond to high velocity impacts in both helmeted and non-helmeted situations. In this study, head impacts were delivered to the front and side of a Hybrid III 50th percentile male anthropomorphic test device (ATD) by a baseball traveling at speeds of 60 mph (27 m/s), 75 mph (34 m/s), and 100 mph (45 m/s). Head impacts were performed on the non-helmeted ATD head and with the ATD wearing a standard batting helmet certified in accordance with the NOCSAE standard. The Hybrid III headform was instrumented with a nine accelerometer array to measure linear accelerations of the head and determine angular accelerations. Peak resultant linear head accelerations for the non-helmeted ATD were approximately 200–400 g for frontal impacts and approximately 220–480 g for lateral impacts. Peak resultant angular head accelerations for the non-helmeted condition were approximately 17,000–32,000 rad/s2 for frontal impacts and approximately 30,000–60,000 rad/s2 for lateral impacts. For the helmeted ATD, peak resultant linear accelerations of the head were approximately 70–300 g for frontal impacts and approximately 80–360 g for lateral impacts. Peak resultant angular head accelerations for the helmeted ATD were approximately 5,000–14,000 rad/s2 for frontal impacts and approximately 7,500–30,000 rad/s2 for lateral impacts. HIC values for the non-helmeted ATD were approximately 193–1,025 for frontal impacts and approximately 241–1,588 for lateral impacts. SI values for the non-helmeted ATD were approximately 235–1,267 for frontal impacts and approximately 285–1,844 for lateral impacts. HIC values for the helmeted ATD were approximately 16–415 for frontal impacts and approximately 23–585 for lateral impacts. SI values for the helmeted ATD were approximately 25–521 for frontal impacts and approximately 32–708 for lateral impacts. In comparison to the non-helmeted condition, the results demonstrate the effectiveness of a batting helmet in mitigating head accelerations for the frontal and lateral impact conditions tested.