The differential diagnosis of syringoma and milia based on the imaging of reflectance confocal microscopy

2020 ◽  
Vol 26 (6) ◽  
pp. 951-953
Author(s):  
Min Gao ◽  
Yan Lin ◽  
Leilei Wang ◽  
Yongmei Yu ◽  
Yan Zhou ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy

scholarly journals The Differential Diagnosis of Hypopigmented Mycosis Fungoides and Vitiligo With Reflectance Confocal Microscopy: A Preliminary Study

2021 ◽  
Vol 7 ◽  
Author(s):  
Huaxu Liu ◽  
Leilei Wang ◽  
Yan Lin ◽  
Xiaofeng Shan ◽  
Min Gao
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Mycosis Fungoides ◽  
Early Stage ◽  
Reflectance Confocal Microscopy ◽  
Inflammatory Conditions ◽  
Dark Space ◽  
Superficial Dermis ◽  
Melanin Contents

Objective: To investigate the role of reflectance confocal microscopy (RCM) in the differential diagnosis of hypopigmented mycosis fungoides (HMF) and vitiligo.Methods: Cases with persistent hypopigmented patches, suspicious of early stage vitiligo, or HMF were imaged with RCM. The melanin contents and inflammatory conditions of the epidermis and superficial dermis of the lesions were compared with the same layers of the adjacent skin, and then, the imaged lesions were biopsied and analyzed by histology.Results: 15 cases were enrolled in this study, and based on the RCM findings, there was just slight or moderate reduction of melanin but no melanin absence in the basal cell layer of HMF lesions. The finding of monomorphous weakly refractile, oval to round cells on the basis of vesicle-like dark space was clearly elucidated in the epidermis of the lesions by RCM, which indicates the Pautrier's microabscesses on histopathology. Among those 15 cases, 13 cases were identified as HMF, and the other two cases were vitiligo, based on RCM findings, which were confirmed by histology analysis.Conclusions: The RCM findings correlated well with histology results in the screening of HMF, which indicates the RCM is an important tool in the early detection and differential diagnosis of HMF.

In vivo reflectance confocal microscopy for the differential diagnosis between vitiligo and nevus depigmentosus

2011 ◽  
Vol 50 (6) ◽  
pp. 740-745 ◽  
Author(s):  
Zhan-Yan Pan ◽  
Fang Yan ◽  
Zhen-hua Zhang ◽  
Qiao-an Zhang ◽  
Lei-hong Xiang ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy

scholarly journals Imaging of Vulva Syringoma With Reflectance Confocal Microscopy

2021 ◽  
Vol 8 ◽  
Author(s):  
Lin Feng ◽  
Yan Lin ◽  
Leilei Wang ◽  
Hongxiao Chen ◽  
Min Gao ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Potential Role ◽  
Reflectance Confocal Microscopy ◽  
Histological Evaluation ◽  
Histological Findings ◽  
Dark Line ◽  
Confocal Images ◽  
Distinct Features

Objectives: To investigate the application of reflectance confocal microscopy (RCM) imaging in diagnosis of vulva syringoma.Methods: Patients with lesions suspicious of syringoma on vulva were enrolled in the study. After informed consent was taken, the lesions were photographed and imaged with RCM. The features of the lesion in confocal images were then analyzed and compared with the biopsy findings for histology correlation.Results: Eleven cases in total were included in the study. The typical RCM features observed in syringoma are the presence of round to oval high refractive, and relatively monomorphous mass of varying sizes in the superficial and middle dermis, usually surrounded with 1–2 layers of light-dark line structures, which were further confirmed by histological evaluation. Ten cases showed classic features of syringoma and 1 case exhibited milia in RCM images.Conclusions: Syringoma has distinct features in RCM imaging, which correlates well with histological findings, highlighting the potential role of RCM in the diagnosis and differential diagnosis of vulva syringoma.

scholarly journals Reflectance confocal microscopy in the diagnosis of pigmented macules of the face: differential diagnosis and margin definition

2019 ◽  
Vol 18 (5) ◽  
pp. 963-969 ◽  
Author(s):  
Francesca Farnetani ◽  
Marco Manfredini ◽  
Johanna Chester ◽  
Silvana Ciardo ◽  
Salvador Gonzalez ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
State Of The Art ◽  
Correct Diagnosis ◽  
The State ◽  
Reflectance Confocal Microscopy ◽  
Diagnostic Algorithms ◽  
Diagnosis And Management ◽  
The Face ◽  
Standardized Terminology

Here we review the state-of-the-art of RCM morphologic descriptors, standardized terminology, and diagnostic algorithms for the assessment of pigmented macules of the face, for their correct diagnosis and management.

scholarly journals Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study

2021 ◽  
pp. e2021127
Author(s):  
Camila Scharf ◽  
Giuseppe Argenziano ◽  
Gabriella Brancaccio ◽  
Gaetano Licata ◽  
Andrea Ronchi ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Diagnostic Accuracy ◽  
High Specificity ◽  
Skin Lesions ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesion ◽  
Cross Sectional ◽  
Present Sample ◽  
Melanocytic Lesions

Background: Different techniques for non-invasive skin examination and early diagnosis of skin lesions are available nowadays, being dermoscopy and reflectance confocal microscopy (RCM) the most diffused ones. Several studies supported the complementary use of dermoscopy and RCM that improves diagnostic accuracy when dealing with melanocytic lesions. Objectives: To analyze RCM diagnostic accuracy in the differential diagnosis between melanocytic and non-melanocytic lesions. Methods: This is a cohort selected cross-sectional study conducted at the Dermatology Unit of the University of Campania L. Vanvitelli, Naples, Italy, from 2012 to 2020. We searched the image database for all excised lesions for which the clinical and dermatoscopic differential diagnosis was between melanocytic and non-melanocytic and for which an RCM examination was performed. Sensitivity, specificity, and diagnostic accuracy values ​​were estimated. Results: The study included 53 cases that were found to have disagreement between clinical, histological and RCM diagnosis, of which, in 31 cases the differential diagnosis was melanocytic vs non-melanocytic lesion. The RCM reached a specificity of 87% (95% CI: 0.73-1) and a sensitivity of 62.5% (95% CI: 0.29-0.96) in the present sample. Diagnostic accuracy was 80.6% (95% CI: 0.67-0.94). Conclusion: RCM has a high specificity in differentiating between difficult-to-diagnose melanocytic and non-melanocytic lesions.

Pink melanocytic and non-melanocytic lesions: how reflectance confocal microscopy can help in differential diagnosis

2015 ◽  
Vol 30 (6) ◽  
pp. 1026-1029 ◽  
Author(s):  
N. deCarvalho ◽  
S. Guida ◽  
L. Spagnol Abraham ◽  
A.M. Cesinaro ◽  
F. Farnetani ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesions

Folliculotropism in pigmented facial macules: Differential diagnosis with reflectance confocal microscopy

2018 ◽  
Vol 27 (3) ◽  
pp. 227-232 ◽  
Author(s):  
Flavia Persechino ◽  
Nathalie De Carvalho ◽  
Silvana Ciardo ◽  
Barbara De Pace ◽  
Alice Casari ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy
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