Pink melanocytic and non-melanocytic lesions: how reflectance confocal microscopy can help in differential diagnosis

2015 ◽  
Vol 30 (6) ◽  
pp. 1026-1029 ◽  
Author(s):  
N. deCarvalho ◽  
S. Guida ◽  
L. Spagnol Abraham ◽  
A.M. Cesinaro ◽  
F. Farnetani ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesions

scholarly journals Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study

2021 ◽  
pp. e2021127
Author(s):  
Camila Scharf ◽  
Giuseppe Argenziano ◽  
Gabriella Brancaccio ◽  
Gaetano Licata ◽  
Andrea Ronchi ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Diagnostic Accuracy ◽  
High Specificity ◽  
Skin Lesions ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesion ◽  
Cross Sectional ◽  
Present Sample ◽  
Melanocytic Lesions

Background: Different techniques for non-invasive skin examination and early diagnosis of skin lesions are available nowadays, being dermoscopy and reflectance confocal microscopy (RCM) the most diffused ones. Several studies supported the complementary use of dermoscopy and RCM that improves diagnostic accuracy when dealing with melanocytic lesions. Objectives: To analyze RCM diagnostic accuracy in the differential diagnosis between melanocytic and non-melanocytic lesions. Methods: This is a cohort selected cross-sectional study conducted at the Dermatology Unit of the University of Campania L. Vanvitelli, Naples, Italy, from 2012 to 2020. We searched the image database for all excised lesions for which the clinical and dermatoscopic differential diagnosis was between melanocytic and non-melanocytic and for which an RCM examination was performed. Sensitivity, specificity, and diagnostic accuracy values ​​were estimated. Results: The study included 53 cases that were found to have disagreement between clinical, histological and RCM diagnosis, of which, in 31 cases the differential diagnosis was melanocytic vs non-melanocytic lesion. The RCM reached a specificity of 87% (95% CI: 0.73-1) and a sensitivity of 62.5% (95% CI: 0.29-0.96) in the present sample. Diagnostic accuracy was 80.6% (95% CI: 0.67-0.94). Conclusion: RCM has a high specificity in differentiating between difficult-to-diagnose melanocytic and non-melanocytic lesions.

scholarly journals Correlation of Dermoscopy With In Vivo Reflectance Confocal Microscopy of Streaks in Melanocytic Lesions

2007 ◽  
Vol 143 (6) ◽  
Author(s):  
Alon Scope ◽  
Melissa Gill ◽  
Cristiane Benveuto-Andrade ◽  
Allan C. Halpern ◽  
Salvador Gonzalez ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesions

scholarly journals Reflectance Confocal Microscopy and Features of Melanocytic Lesions

2009 ◽  
Vol 145 (10) ◽  
Author(s):  
Giovanni Pellacani ◽  
Marco Vinceti ◽  
Sara Bassoli ◽  
Ralph Braun ◽  
Salvador Gonzalez ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesions

scholarly journals The Differential Diagnosis of Hypopigmented Mycosis Fungoides and Vitiligo With Reflectance Confocal Microscopy: A Preliminary Study

2021 ◽  
Vol 7 ◽  
Author(s):  
Huaxu Liu ◽  
Leilei Wang ◽  
Yan Lin ◽  
Xiaofeng Shan ◽  
Min Gao
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Mycosis Fungoides ◽  
Early Stage ◽  
Reflectance Confocal Microscopy ◽  
Inflammatory Conditions ◽  
Dark Space ◽  
Superficial Dermis ◽  
Melanin Contents

Objective: To investigate the role of reflectance confocal microscopy (RCM) in the differential diagnosis of hypopigmented mycosis fungoides (HMF) and vitiligo.Methods: Cases with persistent hypopigmented patches, suspicious of early stage vitiligo, or HMF were imaged with RCM. The melanin contents and inflammatory conditions of the epidermis and superficial dermis of the lesions were compared with the same layers of the adjacent skin, and then, the imaged lesions were biopsied and analyzed by histology.Results: 15 cases were enrolled in this study, and based on the RCM findings, there was just slight or moderate reduction of melanin but no melanin absence in the basal cell layer of HMF lesions. The finding of monomorphous weakly refractile, oval to round cells on the basis of vesicle-like dark space was clearly elucidated in the epidermis of the lesions by RCM, which indicates the Pautrier's microabscesses on histopathology. Among those 15 cases, 13 cases were identified as HMF, and the other two cases were vitiligo, based on RCM findings, which were confirmed by histology analysis.Conclusions: The RCM findings correlated well with histology results in the screening of HMF, which indicates the RCM is an important tool in the early detection and differential diagnosis of HMF.

Correlation of Dermoscopic Structures of Melanocytic Lesions to Reflectance Confocal Microscopy

2007 ◽  
Vol 143 (2) ◽  
Author(s):  
Alon Scope ◽  
Cristiane Benvenuto-Andrade ◽  
Anna-Liza C. Agero ◽  
Allan C. Halpern ◽  
Salvador Gonzalez ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesions

scholarly journals Reflectance Confocal Microscopy: A Promising Tool to Identify Malignancy in Melanocytic Lesions Exhibiting a Dermoscopic Island

2018 ◽  
Vol 109 (6) ◽  
pp. e37-e41
Author(s):  
M. Elosua-González ◽  
R. Gamo-Villegas ◽  
U. Floristán-Muruzábal ◽  
F. Pinedo-Moraleda ◽  
J.L. López-Estebaranz
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Promising Tool ◽  
Melanocytic Lesions

scholarly journals In Vivo Reflectance Confocal Microscopy Enhances Secondary Evaluation of Melanocytic Lesions

2009 ◽  
Vol 129 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Pascale Guitera ◽  
Giovanni Pellacani ◽  
Caterina Longo ◽  
Stefania Seidenari ◽  
Michelle Avramidis ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesions

Dermoscopy, Reflectance Confocal Microscopy and Immunohistochemical Analysis in Melanocytic Lesions with Meyerson's Phenomenon

Dermatology ◽  
2014 ◽  
Vol 229 (4) ◽  
pp. 297-305 ◽  
Author(s):  
André Oliveira ◽  
Edith Arzberger ◽  
Cesare Massone ◽  
Regina Fink-Puches ◽  
Iris Zalaudek ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Immunohistochemical Analysis ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesions

Reflectance confocal microscopy and melanocytic lesions: The road to saving a biopsy.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e21614-e21614
Author(s):  
Ann Mary John ◽  
Attiya Haroon ◽  
Gina Francisco ◽  
Babar K Rao
Keyword(s):  
Confocal Microscopy ◽  
Reflectance Confocal Microscopy ◽  
The Road ◽  
Melanocytic Lesions
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