scholarly journals Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemia

2013 ◽  
Vol 4 (3) ◽  
pp. 297-303 ◽  
Author(s):  
Tomoya Mita ◽  
Shiho Nakayama ◽  
Hiroko Abe ◽  
Masahiko Gosho ◽  
Hitoshi Iida ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells

2021 ◽  
Vol 22 (13) ◽  
pp. 7228
Author(s):  
Ching-Chia Wang ◽  
Huang-Jen Chen ◽  
Ding-Cheng Chan ◽  
Chen-Yuan Chiu ◽  
Shing-Hwa Liu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Protein Expression ◽  
Glucose Uptake ◽  
Glucose Transport ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Urinary acrolein adduct levels have been reported to be increased in both habitual smokers and type-2 diabetic patients. The impairment of glucose transport in skeletal muscles is a major factor responsible for glucose uptake reduction in type-2 diabetic patients. The effect of acrolein on glucose metabolism in skeletal muscle remains unclear. Here, we investigated whether acrolein affects muscular glucose metabolism in vitro and glucose tolerance in vivo. Exposure of mice to acrolein (2.5 and 5 mg/kg/day) for 4 weeks substantially increased fasting blood glucose and impaired glucose tolerance. The glucose transporter-4 (GLUT4) protein expression was significantly decreased in soleus muscles of acrolein-treated mice. The glucose uptake was significantly decreased in differentiated C2C12 myotubes treated with a non-cytotoxic dose of acrolein (1 μM) for 24 and 72 h. Acrolein (0.5–2 μM) also significantly decreased the GLUT4 expression in myotubes. Acrolein suppressed the phosphorylation of glucose metabolic signals IRS1, Akt, mTOR, p70S6K, and GSK3α/β. Over-expression of constitutive activation of Akt reversed the inhibitory effects of acrolein on GLUT4 protein expression and glucose uptake in myotubes. These results suggest that acrolein at doses relevant to human exposure dysregulates glucose metabolism in skeletal muscle cells and impairs glucose tolerance in mice.

scholarly journals Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study

2014 ◽  
Vol 6 (2) ◽  
pp. 164-172 ◽  
Author(s):  
Takahiro Watanabe ◽  
Yoshifumi Tamura ◽  
Saori Kakehi ◽  
Takashi Funayama ◽  
Amalia Gastaldelli ◽  
...  
Keyword(s):  
Pilot Study ◽  
Glucose Metabolism ◽  
Fatty Liver ◽  
Diabetic Patients ◽  
Ectopic Fat ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Effects of High-Dose Simvastatin Therapy on Glucose Metabolism and Ectopic Lipid Deposition in Nonobese Type 2 Diabetic Patients

Diabetes Care ◽  
2008 ◽  
Vol 32 (2) ◽  
pp. 209-214 ◽  
Author(s):  
J. Szendroedi ◽  
C. Anderwald ◽  
M. Krssak ◽  
M. Bayerle-Eder ◽  
H. Esterbauer ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Diabetic Patients ◽  
High Dose ◽  
Lipid Deposition ◽  
Type 2 Diabetic Patients ◽  
Simvastatin Therapy ◽  
Type 2 Diabetic
Sign in / Sign up

Export Citation Format

Share Document