scholarly journals Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study

2014 ◽  
Vol 6 (2) ◽  
pp. 164-172 ◽  
Author(s):  
Takahiro Watanabe ◽  
Yoshifumi Tamura ◽  
Saori Kakehi ◽  
Takashi Funayama ◽  
Amalia Gastaldelli ◽  
...  
Keyword(s):  
Pilot Study ◽  
Glucose Metabolism ◽  
Fatty Liver ◽  
Diabetic Patients ◽  
Ectopic Fat ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Correlational study on the levels of 25-hydroxyvitamin D and non-alcoholic fatty liver disease in type 2 diabetic patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuanyuan Zhang ◽  
Juyi Li ◽  
Yingqun Ni ◽  
Yan Wang ◽  
Huaizhen Liu
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Type 2 Diabetic

Abstract Background It is widely acknowledged that nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus(T2DM) are all chronic metabolic diseases. The objective of this study is to retrospectively probe the association between the 25-hydroxyvitamin D (25-(OH)D) and NAFLD in type 2 diabetic patients. Methods Three hundred thirty-nine T2DM patients participated in this research and from November 2018 to September 2019 and were divided into simple T2DM group (108 cases) and T2DM with NAFLD group (231 cases) in conformity with abdominal ultrasound diagnosis. The NAFLD fibrosis score (NFS) ≥0.676 was defined as progressive liver fibrosis.231 T2DM with NAFLD patients were categorized into two subgroups: progressive liver fibrosis subgroup (48 cases) and without progressive liver fibrosis subgroup (183 cases). Results The prevalence of NAFLD by Abdominal ultrasonography was 68%.The results indicated that the levels of 25-(OH) D were significantly lower in T2DM with NAFLD group than that in simple T2DM group(P < 0.01). The levels of 25-(OH) D were significantly lower in progressive liver fibrosis subgroup than that in patients without progressive liver fibrosis and simple T2DM,and 25-(OH) D levels were lower in without progressive liver fibrosis subgroup than that in simple T2DM group(p < 0.01 or p < 0.05). Multivariate logistic regression analysis showed that levels of 25-(OH) D were negative correlation with risk of NAFLD and progressive liver fibrosis(p = 0.011、p = 0.044,respectively). Conclusions we could come to a conclusion that low levels of 25-(OH) D was a risk factor for NAFLD and progressive liver fibrosis in T2DM patients.

scholarly journals Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells

2021 ◽  
Vol 22 (13) ◽  
pp. 7228
Author(s):  
Ching-Chia Wang ◽  
Huang-Jen Chen ◽  
Ding-Cheng Chan ◽  
Chen-Yuan Chiu ◽  
Shing-Hwa Liu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Protein Expression ◽  
Glucose Uptake ◽  
Glucose Transport ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Urinary acrolein adduct levels have been reported to be increased in both habitual smokers and type-2 diabetic patients. The impairment of glucose transport in skeletal muscles is a major factor responsible for glucose uptake reduction in type-2 diabetic patients. The effect of acrolein on glucose metabolism in skeletal muscle remains unclear. Here, we investigated whether acrolein affects muscular glucose metabolism in vitro and glucose tolerance in vivo. Exposure of mice to acrolein (2.5 and 5 mg/kg/day) for 4 weeks substantially increased fasting blood glucose and impaired glucose tolerance. The glucose transporter-4 (GLUT4) protein expression was significantly decreased in soleus muscles of acrolein-treated mice. The glucose uptake was significantly decreased in differentiated C2C12 myotubes treated with a non-cytotoxic dose of acrolein (1 μM) for 24 and 72 h. Acrolein (0.5–2 μM) also significantly decreased the GLUT4 expression in myotubes. Acrolein suppressed the phosphorylation of glucose metabolic signals IRS1, Akt, mTOR, p70S6K, and GSK3α/β. Over-expression of constitutive activation of Akt reversed the inhibitory effects of acrolein on GLUT4 protein expression and glucose uptake in myotubes. These results suggest that acrolein at doses relevant to human exposure dysregulates glucose metabolism in skeletal muscle cells and impairs glucose tolerance in mice.

A pilot study to detect oxidative stress in type 2 diabetic patients

2016 ◽  
Vol 96 ◽  
pp. S62
Author(s):  
Ayse C. Hamamcioglu ◽  
Zehra Safi-Oz ◽  
Yasin Hazer ◽  
Dilek Arpaci ◽  
Furuzan Kokturk
Keyword(s):  
Oxidative Stress ◽  
Pilot Study ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Pilot study: Hypoglycemic and antiglycation activities of bitter melon (Momordica charantia L.) in type 2 diabetic patients

2013 ◽  
Vol 6 (8) ◽  
pp. 859-864 ◽  
Author(s):  
Wilai Trakoon-osot ◽  
Uthai Sotanaphun ◽  
Pariya Phanachet ◽  
Supatra Porasuphatana ◽  
Umaporn Udomsubpayakul ◽  
...  
Keyword(s):  
Pilot Study ◽  
Momordica Charantia ◽  
Diabetic Patients ◽  
Bitter Melon ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic
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