scholarly journals Association of Adiponectin Level and Variants in the Adiponectin Gene with Glucose Metabolism, Energy Expenditure, and Cytokines in Offspring of Type 2 Diabetic Patients

2005 ◽  
Vol 90 (7) ◽  
pp. 4216-4223 ◽  
Author(s):  
Urpu Salmenniemi ◽  
Jelena Zacharova ◽  
Eija Ruotsalainen ◽  
Ilkka Vauhkonen ◽  
Jussi Pihlajamäki ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Energy Expenditure ◽  
Adiponectin Level ◽  
Diabetic Patients ◽  
Adiponectin Gene ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells

2021 ◽  
Vol 22 (13) ◽  
pp. 7228
Author(s):  
Ching-Chia Wang ◽  
Huang-Jen Chen ◽  
Ding-Cheng Chan ◽  
Chen-Yuan Chiu ◽  
Shing-Hwa Liu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Protein Expression ◽  
Glucose Uptake ◽  
Glucose Transport ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Urinary acrolein adduct levels have been reported to be increased in both habitual smokers and type-2 diabetic patients. The impairment of glucose transport in skeletal muscles is a major factor responsible for glucose uptake reduction in type-2 diabetic patients. The effect of acrolein on glucose metabolism in skeletal muscle remains unclear. Here, we investigated whether acrolein affects muscular glucose metabolism in vitro and glucose tolerance in vivo. Exposure of mice to acrolein (2.5 and 5 mg/kg/day) for 4 weeks substantially increased fasting blood glucose and impaired glucose tolerance. The glucose transporter-4 (GLUT4) protein expression was significantly decreased in soleus muscles of acrolein-treated mice. The glucose uptake was significantly decreased in differentiated C2C12 myotubes treated with a non-cytotoxic dose of acrolein (1 μM) for 24 and 72 h. Acrolein (0.5–2 μM) also significantly decreased the GLUT4 expression in myotubes. Acrolein suppressed the phosphorylation of glucose metabolic signals IRS1, Akt, mTOR, p70S6K, and GSK3α/β. Over-expression of constitutive activation of Akt reversed the inhibitory effects of acrolein on GLUT4 protein expression and glucose uptake in myotubes. These results suggest that acrolein at doses relevant to human exposure dysregulates glucose metabolism in skeletal muscle cells and impairs glucose tolerance in mice.

Resting energy expenditure in type 2 diabetic patients and the effect of insulin bolus

2014 ◽  
Vol 106 (3) ◽  
pp. 605-610 ◽  
Author(s):  
Silvio Buscemi ◽  
Maria Donatelli ◽  
Giuseppe Grosso ◽  
Sonya Vasto ◽  
Fabio Galvano ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic ◽  
Resting Energy

scholarly journals Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemia

2013 ◽  
Vol 4 (3) ◽  
pp. 297-303 ◽  
Author(s):  
Tomoya Mita ◽  
Shiho Nakayama ◽  
Hiroko Abe ◽  
Masahiko Gosho ◽  
Hitoshi Iida ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic
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