scholarly journals Low expression of GSTP1 in the aqueous humour of patients with primary open‐angle glaucoma

2021 ◽  
Vol 25 (6) ◽  
pp. 3063-3079
Author(s):  
Aihua Liu ◽  
Liming Wang ◽  
Qiang Feng ◽  
Dandan Zhang ◽  
Kexi Chen ◽  
...  
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Low Expression

scholarly journals Cellular and plasma fibronectin in the aqueous humour of primary open-angle glaucoma, exfoliative glaucoma and cataract patients

Eye ◽  
1998 ◽  
Vol 12 (5) ◽  
pp. 886-890 ◽  
Author(s):  
Minna Vesaluoma ◽  
Päivi Mertaniemi ◽  
Sari Mannonen ◽  
Ilkka Lehto ◽  
Risto Uusitalo ◽  
...  
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Plasma Fibronectin ◽  
Exfoliative Glaucoma ◽  
Cataract Patients

scholarly journals Tear and aqueous humour cytokine profile in primary open‐angle glaucoma

2020 ◽  
Vol 98 (6) ◽  
Author(s):  
Barbara Burgos‐Blasco ◽  
Beatriz Vidal‐Villegas ◽  
Federico Saenz‐Frances ◽  
Laura Morales‐Fernandez ◽  
Lucia Perucho‐Gonzalez ◽  
...  
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Cytokine Profile ◽  
Open Angle

scholarly journals SELENIUM AND SELENOPROTEIN P1 LEVELS ARE RELATED TO PRIMARY OPEN-ANGLE GLAUCOMA / NIVOI SELENA I SELENOPROTEINA P1 POVEZANI SU SA PRIMARNIM GLAUKOMOM OTVORENOG UGLA

2013 ◽  
Vol 33 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Mohammad Najafi ◽  
Morteza Nouruzi Yeganeh ◽  
Arezoo Miraftabi ◽  
Reza Zarei ◽  
Isa Noormohammadi
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Reduced Glutathione ◽  
Open Angle Glaucoma ◽  
Serum Levels ◽  
Visual Field Defects ◽  
Unknown Etiology ◽  
Serum Selenium ◽  
Open Angle ◽  
Significant Difference

Summary Background Glaucoma is a highly prevalent eye disease related to optic nerve lesions and visual field defects. Primary Open-Angle Glaucoma (POAG) is a type of glaucoma that occurs frequently with unknown etiology. In this study, we investigated the serum levels of selenium, selenoprotein P1, glutathione, hemolysate glutathione peroxidase1 (GPx1) activity and aqueous humour selenium in POAG patients. Methods Ninety sex- and age-matched subjects (POAG patients; n=45 and, controls; n=45) with the controlled confounders (smoking, hypertension and alcohol beverages) were recruited on clinical histories and exams. The serum and aqueous humour selenium levels were measured using GFAAS technique. The serum selenoprotein P1 level was assayed with the ELISA method. The hemolysate GPx1 activity and serum reduced glutathione level were also measured using known colorimetric techniques. Results The serum selenium (P=0.01) and selenoprotein P1 (P<0.001) levels were significantly high in POAG patients. Furthermore, the aqueous humour selenium level was significantly high among patients as compared to controls (64.68±13.07 vs. 58.36±13.76 ng/mL, P=0.02). The results did not show a significant difference (P=0.36) in the hemolysate GPx1 activity between the groups. The cutoff points for intraocular pressure (IOP) and serum selenoprotein P1 parameters were estimated to be 39 mmHg (sensitivity 97.5%; 1-specificity 6.5%) and 188 mg/mL (sensitivity 93.5%; 1-specificity 14%), respectively.

scholarly journals A study of aqueous humour proteins in patients of primary open angle glaucoma

2010 ◽  
Vol 01 (02) ◽  
pp. 110-114 ◽  
Author(s):  
Meena Zaidi ◽  
Azra Jilani ◽  
Padmawati Bhattacharya ◽  
Najmul Islam ◽  
Shahid Alam
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle

Freeze-controlled Crystallisation of the Aqueous Humour in Glaucomatous and Non-glaucomatous Patients

2010 ◽  
Vol 04 (01) ◽  
pp. 29
Author(s):  
Christoph Faschinger ◽  
Franz Rabensteiner Dieter ◽  
Christian Eberle ◽  
Georg Mossböck ◽  
Otto Schmut ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Trabecular Meshwork ◽  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Pigmentary Glaucoma ◽  
Multifactorial Disease ◽  
Open Angle ◽  
Microscope Slide ◽  
Trabecular Meshwork Cells

The purpose of this study was to investigate the aqueous humour of glaucomatous and non-glaucomatous patients by freeze-controlled crystallisation qualitatively to detect a possible difference. Aqueous humour was taken from 20 patients with different kinds of glaucoma (11 primary open-angle glaucoma, eight pseudo-exfoliation glaucoma, one pigmentary glaucoma) and compared with samples from 40 patients with cataracts and to samples from seven patients with cataract and glaucoma; 1μl of each sample was applied to a microscope slide and put in a deep-freezer at a constant temperature of -20°C for 24 hours. During this time, the water evaporated and distinct crystal patterns developed. These patterns were examined stereo-microscopically, stored digitally and compared with each other. Many distinct crystals of different sizes and formations were obtained. No obvious differences in the crystal patterns could be found between the three groups (patients with glaucoma, cataract or cataract and glaucoma). As a multifactorial disease, open-angle glaucoma is characterised by specific changes to the trabecular meshwork cells with an accumulation of deposits of extracellular matrix. Since the trabeculum is rinsed consistently by aqueous humour, changes of the compounds might influence these cells. Alterations concerning this were published. In contrast to the ferning test, one of several methods of examining fluids with patterns that are highly dependent on temperature and humidity, our examinations with freeze-controlled crystallisation at a constant and controlled temperature of – 20°C gave more valid results. In our study we could not find obvious differences in the crystal patterns of patients with cataract, glaucoma or cataract and glaucoma.

scholarly journals Lactate Dehydrogenase and Oxidative Stress Activity in Primary Open-Angle Glaucoma Aqueous Humour

2010 ◽  
Vol 10 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Predrag Jovanović ◽  
Lepša Žorić ◽  
Ivan Stefanović ◽  
Boban Džunić ◽  
Jasmina Djordjević-Jocić ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lactic Acid ◽  
Lactate Dehydrogenase ◽  
Biochemical Parameters ◽  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Kinetic Method ◽  
Control Group ◽  
Open Angle

Lactate dehydrogenase (LDH) and lactate are some of the hypoxy biochemical parameters. Extracellular activity of this enzyme increases under the condition of oxidative stress, since the cell integrity can be disrupted during the lipid peroxidation process. Subsequently that leads to the increase level of the lactic acid and lactic acid salts. The objective of this investigation is establishing the level of LDH, LDH1 (HBDH) and the lactate concentration in aqueous humour in patients with primary open-angle glaucoma.Biochemical analysis have been made by enzymatic-colometric method (lactate) and UV-kinetic method (LDH and HBDH) in aqueous humour of 30 patients (42 eyes) with primary open-angle glaucoma (POAG) and 30 patients (40 eyes) with cataract (the control group).The increased values of lactate and the activity of LDH and HBDH enzyme in aqueous humour of POAG patients in correlation with the control group are the results not only of oxidative stress but also of hypoxy and the mitochondry oxidative function (p<0,001).The increased activity of the examined biochemical parameters in the aqueous humour of the POAG patients points to the fact that other mechanisms, besides IOP, have a role in glaucoma pathogenesis.

Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

2020 ◽  
pp. 97-105
Author(s):  
E. N. Simakova ◽  
O. V. Stenkova
Keyword(s):  
Intraocular Pressure ◽  
Drug Therapy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Open Angle ◽  
Complex Treatment ◽  
Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

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