scholarly journals Author Response: Comparison of MicroRNA Expression in Aqueous Humour of Normal and Primary Open-Angle Glaucoma Patients Using PCR Arrays: A Pilot Study

2017 ◽  
Vol 58 (12) ◽  
pp. 4989 ◽  
Author(s):  
Hari Jayaram ◽  
Diana C. Lozano ◽  
Elaine C. Johnson ◽  
Tiffany E. Choe ◽  
William O. Cepurna ◽  
...  
Keyword(s):  
Pilot Study ◽  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Microrna Expression ◽  
Author Response ◽  
Open Angle

scholarly journals Comparison of MicroRNA Expression in Aqueous Humor of Normal and Primary Open-Angle Glaucoma Patients Using PCR Arrays: A Pilot Study

2017 ◽  
Vol 58 (7) ◽  
pp. 2884 ◽  
Author(s):  
Hari Jayaram ◽  
Jay I. Phillips ◽  
Diana C. Lozano ◽  
Tiffany E. Choe ◽  
William O. Cepurna ◽  
...  
Keyword(s):  
Pilot Study ◽  
Aqueous Humor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Microrna Expression ◽  
Open Angle

scholarly journals Cellular and plasma fibronectin in the aqueous humour of primary open-angle glaucoma, exfoliative glaucoma and cataract patients

Eye ◽  
1998 ◽  
Vol 12 (5) ◽  
pp. 886-890 ◽  
Author(s):  
Minna Vesaluoma ◽  
Päivi Mertaniemi ◽  
Sari Mannonen ◽  
Ilkka Lehto ◽  
Risto Uusitalo ◽  
...  
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Plasma Fibronectin ◽  
Exfoliative Glaucoma ◽  
Cataract Patients

scholarly journals Tear and aqueous humour cytokine profile in primary open‐angle glaucoma

2020 ◽  
Vol 98 (6) ◽  
Author(s):  
Barbara Burgos‐Blasco ◽  
Beatriz Vidal‐Villegas ◽  
Federico Saenz‐Frances ◽  
Laura Morales‐Fernandez ◽  
Lucia Perucho‐Gonzalez ◽  
...  
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Cytokine Profile ◽  
Open Angle

scholarly journals SELENIUM AND SELENOPROTEIN P1 LEVELS ARE RELATED TO PRIMARY OPEN-ANGLE GLAUCOMA / NIVOI SELENA I SELENOPROTEINA P1 POVEZANI SU SA PRIMARNIM GLAUKOMOM OTVORENOG UGLA

2013 ◽  
Vol 33 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Mohammad Najafi ◽  
Morteza Nouruzi Yeganeh ◽  
Arezoo Miraftabi ◽  
Reza Zarei ◽  
Isa Noormohammadi
Keyword(s):  
Aqueous Humour ◽  
Primary Open Angle Glaucoma ◽  
Reduced Glutathione ◽  
Open Angle Glaucoma ◽  
Serum Levels ◽  
Visual Field Defects ◽  
Unknown Etiology ◽  
Serum Selenium ◽  
Open Angle ◽  
Significant Difference

Summary Background Glaucoma is a highly prevalent eye disease related to optic nerve lesions and visual field defects. Primary Open-Angle Glaucoma (POAG) is a type of glaucoma that occurs frequently with unknown etiology. In this study, we investigated the serum levels of selenium, selenoprotein P1, glutathione, hemolysate glutathione peroxidase1 (GPx1) activity and aqueous humour selenium in POAG patients. Methods Ninety sex- and age-matched subjects (POAG patients; n=45 and, controls; n=45) with the controlled confounders (smoking, hypertension and alcohol beverages) were recruited on clinical histories and exams. The serum and aqueous humour selenium levels were measured using GFAAS technique. The serum selenoprotein P1 level was assayed with the ELISA method. The hemolysate GPx1 activity and serum reduced glutathione level were also measured using known colorimetric techniques. Results The serum selenium (P=0.01) and selenoprotein P1 (P<0.001) levels were significantly high in POAG patients. Furthermore, the aqueous humour selenium level was significantly high among patients as compared to controls (64.68±13.07 vs. 58.36±13.76 ng/mL, P=0.02). The results did not show a significant difference (P=0.36) in the hemolysate GPx1 activity between the groups. The cutoff points for intraocular pressure (IOP) and serum selenoprotein P1 parameters were estimated to be 39 mmHg (sensitivity 97.5%; 1-specificity 6.5%) and 188 mg/mL (sensitivity 93.5%; 1-specificity 14%), respectively.

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